Targeting of Prostate Cancer with Hyaluronan-Binding Proteins

2005 ◽  
Author(s):  
Charles Underhill ◽  
Lurong Zhang
Keyword(s):  
Prostate Cancer ◽  
Binding Proteins ◽  
Hyaluronan Binding

Structural and Functional Diversity of Hyaluronan-Binding Proteins

2004 ◽  
pp. 189-204 ◽  
Author(s):  
CHARLES D. BLUNDELL ◽  
NICHOLAS T. SEYFRIED ◽  
ANTHONY J. DAY
Keyword(s):  
Functional Diversity ◽  
Binding Proteins ◽  
Hyaluronan Binding

scholarly journals P36. The calcium binding proteins S100A8 and S100A9 as novel markers for human prostate cancer

2006 ◽  
Vol 4 (6) ◽  
pp. 40
Author(s):  
Alexander Hermani ◽  
Rainer Grobholz ◽  
Lutz Trojan ◽  
Peter Angel ◽  
Doris Mayer
Keyword(s):  
Prostate Cancer ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins ◽  
Human Prostate ◽  
Human Prostate Cancer

The Role of Hyaluronan and Hyaluronan Binding Proteins in Asthma.

2009 ◽  
Author(s):  
JC Liang ◽  
D Jiang ◽  
J Ingram ◽  
Y Jung ◽  
T Church ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Hyaluronan Binding

284 MIR-145 FUNCTIONS AS TUMOR SUPPRESSOR AND REGULATES ACTIN-BINDING PROTEINS (FSCN1 AND SWAP70) IN PROSTATE CANCER

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Takeshi Chiyomaru ◽  
Kazumori Kawakami ◽  
Hideki Enokida ◽  
Shuichi Tatarano ◽  
Hirofumi Yoshino ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Binding Proteins ◽  
Actin Binding ◽  
Actin Binding Proteins

scholarly journals Dysregulation of Sterol Response Element-Binding Proteins and Downstream Effectors in Prostate Cancer during Progression to Androgen Independence

2004 ◽  
Vol 64 (6) ◽  
pp. 2212-2221 ◽  
Author(s):  
Susan L. Ettinger ◽  
Richard Sobel ◽  
Tanis G. Whitmore ◽  
Majid Akbari ◽  
Dawn R. Bradley ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Binding Proteins ◽  
Response Element ◽  
Androgen Independence ◽  
Downstream Effectors

scholarly journals An Essential Role for the Interaction Between Hyaluronan and Hyaluronan Binding Proteins During Joint Development

1998 ◽  
Vol 46 (5) ◽  
pp. 641-651 ◽  
Author(s):  
Gary P. Dowthwaite ◽  
Jo C. W. Edwards ◽  
Andrew A. Pitsillides
Keyword(s):  
Actin Filament ◽  
Binding Proteins ◽  
Joint Line ◽  
Joint Formation ◽  
Capping Protein ◽  
Initial Separation ◽  
Actin Capping Protein ◽  
Filament Bundles ◽  
Actin Capping ◽  
Hyaluronan Binding

We studied the expression of hyaluronan binding proteins (HABPs) during the development of embryonic chick joints, using immunocytochemistry and biotinylated HA. The expression of actin capping proteins and of actin itself was also studied because the cytoskeleton is important in controlling HA-HABP interactions. Three cell surface HABPs were localized in the epiphyseal cartilage, articular fibrocartilage, and interzone that comprise the developing joint. Of these three HABPs, CD44 was associated with the articular fibrocartilages and interzone, whereas RHAMM and the IVd4 epitope were associated with all three tissues. Biotinylated HA was localized to interzone and articular fibrocartilages before cavity formation and within epiphyseal chondrocytes post cavitation. Actin filament bundles were observed at the developing joint line, as was the expression of the actin capping protein moesin. Manipulation of joint cavity development, using oligosaccharides of HA, disrupted joint formation and was associated with decreases in CD44 and actin filament expression as well as decreased hyaluronan synthetic capability. These results suggest that HA is actively bound by CD44 at the developing joint line and that HA-HABP interactions play a major role in the initial separation events occurring during joint formation.

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