The Role of Protein Elongation Factor EEF1A2 in Breast Cancer

2004 ◽  
Author(s):  
Jonathan M. Lee
Keyword(s):  
Breast Cancer ◽  
Elongation Factor ◽  
Protein Elongation

Expression of protein elongation factor eEF1A2 predicts favorable outcome in breast cancer

2006 ◽  
Vol 102 (1) ◽  
pp. 31-41 ◽  
Author(s):  
Geeta Kulkarni ◽  
Dmitry A. Turbin ◽  
Anahita Amiri ◽  
Sujeeve Jeganathan ◽  
Miguel A. Andrade-Navarro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Elongation Factor ◽  
Favorable Outcome ◽  
Protein Elongation

scholarly journals Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Kawinthra Khwanraj ◽  
Suriyat Madlah ◽  
Khwanthana Grataitong ◽  
Permphan Dharmasaroja
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mrna Level ◽  
Elongation Factor ◽  
Relative Increase ◽  
Mtor Pathway ◽  
Gene Profiling ◽  
Cellular Model ◽  
Protein Elongation

The PI3K/Akt/mTOR pathway is one of dysregulated pathways in Parkinson’s disease (PD). Previous studies in nonneuronal cells showed that Akt regulation can be increased by eukaryotic protein elongation factor 1 alpha 2 (eEF1A2). eEF1A2 is proposed to contribute protection against apoptotic death, likely through activation of the PI3K/Akt pathway. Whether eEF1A2 plays a role in the prevention of cell death in PD has not been investigated. Recently, gene profiling on dopaminergic neurons from postmortem PD patients showed both upregulation and downregulation of some PI3K and mTOR genes. In this paper, the expression of all gene members of the PI3K/Akt/mTOR pathway in relation to those of the eEF1A isoforms in a cellular model of PD was investigated at the mRNA level. The results showed a similar trend of upregulation of genes of the eEF1A isoforms (eEF1A1andeEF1A2) and of the PI3K (classes I–III)/Akt (Akt1,Akt2, andAkt3)/mTOR (mTORC1andmTORC2) pathway in both nondifferentiated and differentiated SH-SY5Y dopaminergic cells treated with 1-methyl-4-phenylpyridinium (MPP+). Upregulation ofeEF1A2,Akt1, andmTORC1was consistent with the relative increase of eEF1A2, Akt, phospho-Akt, and mTORC1 proteins. The possible role of eEF1A isoforms in the regulation of the PI3K/Akt/mTOR pathway in PD is discussed.

Role of social support and pro-health behaviors in fighting breast cancer

2014 ◽  
Vol 12 (4) ◽  
pp. 278-289
Author(s):  
Krystyna Kurowska ◽  
◽  
Izabela Adamczyk ◽  
Keyword(s):  
Breast Cancer ◽  
Social Support ◽  
Health Behaviors

The treatment of brain metastasis from breast cancer, role of blood-brain barrier disruption and early experience with trastuzumab

Therapy ◽  
2006 ◽  
Vol 3 (1) ◽  
pp. 97-112 ◽  
Author(s):  
Rose Marie Tyson ◽  
Dale F Kraemer ◽  
Matthew A Hunt ◽  
Leslie L Muldoon ◽  
Peter Orbay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Blood Brain Barrier ◽  
Early Experience ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption

The role of primary care centers in Saudi Arabia in the early detection of breast cancer

2019 ◽  
pp. 620-624
Author(s):  
Saad Alhumaidi ◽  
Abdullah Alshehri ◽  
Abdullah Altowairqi ◽  
Ahmad Alharthy ◽  
Bader Malki
Keyword(s):  
Breast Cancer ◽  
Primary Care ◽  
Saudi Arabia ◽  
Early Detection
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