Applying Statistical Models to Mammographic Screening Data to Understand Growth and Progression of Ductal Carcinoma in Situ

2004 ◽  
Author(s):  
Dorota Gertig ◽  
Bircan Erbas ◽  
Graham Byrnes ◽  
James Dowty
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Statistical Models ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Mammographic Screening

scholarly journals Readmissions and complications in breast ductal carcinoma in situ: A retrospective study comparing screen- and non-screen-detected patients

2020 ◽  
Vol 16 ◽  
pp. 174550652096589
Author(s):  
Julieta Politi ◽  
María Sala ◽  
Laia Domingo ◽  
María Vernet-Tomas ◽  
Marta Román ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Confidence Interval ◽  
Ductal Carcinoma In Situ ◽  
Odds Ratio ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Screening Program ◽  
Population Based ◽  
Mammographic Screening

Objective: Population-wide mammographic screening programs aim to reduce breast cancer mortality. However, a broad view of the harms and benefits of these programs is necessary to favor informed decisions, especially in the earliest stages of the disease. Here, we compare the outcomes of patients diagnosed with breast ductal carcinoma in situ in participants and non-participants of a population-based mammographic screening program. Methods: A retrospective cohort study of all patients diagnosed with breast ductal carcinoma in situ between 2000 and 2010 within a single hospital. A total of 211 patients were included, and the median follow-up was 8.4 years. The effect of detection mode (screen-detected and non-screen-detected) on breast cancer recurrences, readmissions, and complications was evaluated through multivariate logistic regression analysis. Results: In the majority of women, breast ductal carcinoma in situ was screen-detected (63.5%). Screen-detected breast ductal carcinoma in situ was smaller in size compared to those non-screen-detected (57.53% < 20 mm versus 78.03%, p = 0.002). Overall, breast-conserving surgery was the most frequent surgery (86.26%); however, mastectomy was higher in non-screen-detected breast ductal carcinoma in situ (20.78% versus 9.7%, p = 0.024). Readmissions for mastectomy were more frequent in non-screen-detected breast ductal carcinoma in situ. Psychological complications, such as fatigue, anxiety, and depression, had a prevalence of 15% within our cohort. Risk of readmissions and complications was higher within the non-screen-detected group, as evidenced by an odds ratio = 6.25 (95% confidence interval = 1.95–19.99) for readmissions and an odds ratio = 2.41 (95% confidence interval = 1.95–4.86) for complications. Conclusions: Our findings indicate that women with breast ductal carcinoma in situ breast cancer diagnosed through population-based breast cancer screening program experience a lower risk of readmissions and complications than those diagnosed outside these programs. These findings can help aid women and health professionals make informed decisions regarding screening.

Relationship between mammographic screening intervals and size and histology of ductal carcinoma in situ.

1999 ◽  
Vol 172 (2) ◽  
pp. 313-317 ◽  
Author(s):  
K L Carlson ◽  
M A Helvie ◽  
M A Roubidoux ◽  
C G Kleer ◽  
H A Oberman ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Mammographic Screening ◽  
Screening Intervals

scholarly journals The detection of ductal carcinoma in situ at mammographic screening enables the diagnosis of small, grade 3 invasive tumours

1997 ◽  
Vol 75 (4) ◽  
pp. 542-544 ◽  
Author(s):  
AJ Evans ◽  
SE Pinder ◽  
DRJ Snead ◽  
ARM Wilson ◽  
IO Ellis ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Mammographic Screening ◽  
Grade 3

scholarly journals Microarray analysis of ductal carcinoma in situ samples obtained by puncture from surgical resection specimens

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Tomoo Jikuzono ◽  
Eriko Manabe ◽  
Shoko Kure ◽  
Haruki Akasu ◽  
Tomoko Ishikawa ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Mammographic Screening ◽  
Medical Treatments ◽  
Non Invasive ◽  
Genome Wide ◽  
Invasive Property

Abstract Objective The incidence of ductal carcinoma in situ (DCIS) is increasing due to more widespread mammographic screening. DCIS, the earliest form of breast cancer, is non-invasive at the time of detection. If DCIS tissues are left undetected or untreated, it can spread to the surrounding breast tissue. Thus, surgical resection is the standard treatment. Understanding the mechanism underlying the non-invasive property of DCIS could lead to more appropriate medical treatments, including nonsurgical options. Data description We conducted a microarray-based genome-wide transcriptome analysis using DCIS specimens obtained by puncture from surgical specimens immediately after surgery.

scholarly journals Ductal Carcinoma In Situ of the Breast: An Update with Emphasis on Radiological and Morphological Features as Predictive Prognostic Factors

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 609 ◽  
Author(s):  
Lucia Salvatorelli ◽  
Lidia Puzzo ◽  
Giada Maria Vecchio ◽  
Rosario Caltabiano ◽  
Valentina Virzì ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Mammographic Screening ◽  
Luminal A ◽  
Risk Of Death ◽  
Increased Risk ◽  
Magnetic Resonance Imaging Mri

Ductal carcinoma in situ (DCIS) shows overlapping epidemiology with invasive ductal carcinoma of the breast, sharing similar risk factorssuch as age, mammographic density, family history, and hormonal therapy as well as genetic factors such as BRCA1/BRCA2, histotypes, and molecular subtypes such as luminal A and B, HER2 enriched, and basal-type, thus suggesting its potential precursor role. A small percentage of patients with a history of DCIS die without a documented intermediate diagnosis of invasive breast carcinoma (IBC). The increased risk of death is usually associated with ipsilateral recurrence such as IBC. The slightly variable incidence of DCIS in different countries is mainly due to a different diffusion of mammographic screening and variability of the risk factors. The majority of DCIS lesions are not palpable lesions, which can be only radiologically detected because of the association with microcalcifications. Mammography is a highly sensitive diagnostic procedure for detecting DCIS with microcalcifications, while magnetic resonance imaging (MRI) is considered more sensitive to detect DCIS without calcifications and/or multifocal lesions. The aim of the present overview was to focus on the clinical, radiological, and pathological features of DCIS of the breast, with an emphasis on the practical diagnostic approach, predictive prognostic factors, and therapeutic options.

scholarly journals DUCTAL CARCINOMA IN SITU OF THE BREAST: A CASE REPORT WITH AN ATYPICAL CLINICAL PRESENTATION

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Joyce Campodonio ◽  
Ana Mayra Oliveira ◽  
Flávio A Machado
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Nipple Discharge ◽  
Mammographic Screening ◽  
Axillary Node ◽  
Palpable Mass ◽  
Bloody Nipple Discharge ◽  
The Right

Ductal carcinoma in situ (DCIS) of the breast is a proliferative lesion, precursor of cancer, which has been increasingly diagnosed due to mammographic screening. Tumor size itself does not determine whether the lesion is in situ or invasive, so it is essential to emphasize that DCIS can present with variable extension. We report a case of a 44-year-old female patient that was diagnosed a great (12 cm) DCIS of the breast without microinvasion through pathologic examination. The patient presented with an increase of the right breast, acyclic mastalgia and right bloody nipple discharge. Mammography was inconclusive, the ultrasound suggested inflammation and the incisional biopsy revealed DCIS nuclear grade 3 with compromised lateral margins. It was performed simple mastectomy and axillary node sampling. The clinical presentations of benign and malignant diseases of the breast are variable. The most common symptoms reported by women are pain, palpable mass or nipple discharge. The literature reveals that the extent of this type of cancer is variable, being found in a review intraductal lesions up to 5.4 cm, size smaller than that one that was found in this patient. This finding makes the clinical apresentation interesting to be discussed. Although mammography is the most efficient method to diagnose this injury, clinical breast exam should be performed in all gynecological independent of patient age because it is useful for diagnosing early lesion, considering that it is a palpable lesion.

scholarly journals Ductal carcinoma in situ of the breast: morphological and molecular features implicated in progression

2014 ◽  
Vol 34 (1) ◽  
Author(s):  
Dirce M. Carraro ◽  
Eliana V. Elias ◽  
Victor P. Andrade
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Multidisciplinary Approach ◽  
Ductal Carcinoma ◽  
Mammographic Screening ◽  
Integrated Analysis ◽  
Molecular Features ◽  
Patient Groups ◽  
Non Palpable Lesions

The spread of mammographic screening programmes around the world, including in developing countries, has substantially contributed to the diagnosis of small non-palpable lesions, which has increased the detection rate of DCIS (ductal carcinoma in situ). DCIS is heterogeneous in several ways, such as its clinical presentation, morphology and genomic profile. Excellent outcomes have been reported; however, many questions remain unanswered. For example, which patients groups are overtreated and could instead benefit from minimal intervention and which patient groups require a more traditional multidisciplinary approach. The development of a comprehensive integrated analysis that includes the radiological, morphological and genetic aspects of DCIS is necessary to answer these questions. This review focuses on discussing the significant findings about the morphological and molecular features of DCIS and its progression that have helped to uncover the biological and genetic heterogeneity of this disease. The knowledge gained in recent years might allow the development of tailored clinical management for women with DCIS in the future.

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