Centrosome Amplification: A Potential Marker of Breast Cancer Aggressiveness

2004 ◽  
Author(s):  
Antonino B. D'Assoro
Keyword(s):  
Breast Cancer ◽  
Centrosome Amplification ◽  
Potential Marker ◽  
Cancer Aggressiveness

scholarly journals 124P Lack of HDAC1 and HDAC2 promote breast cancer aggressiveness

2016 ◽  
Vol 27 ◽  
pp. ix37
Author(s):  
N.S. Kamarulzaman ◽  
H.D. Dewadas ◽  
N.S. Yaacob ◽  
N.F. Mokhtar
Keyword(s):  
Breast Cancer ◽  
Cancer Aggressiveness ◽  
Promote Breast Cancer

scholarly journals Plasma Level of MMP-10 May Be a Prognostic Marker in Early Stages of Breast Cancer

2020 ◽  
Vol 9 (12) ◽  
pp. 4122
Author(s):  
Barbara Maria Piskór ◽  
Andrzej Przylipiak ◽  
Emilia Dąbrowska ◽  
Iwona Sidorkiewicz ◽  
Marek Niczyporuk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Area Under The Curve ◽  
Disease Stage ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Early Stages ◽  
Potential Marker ◽  
Breast Cancer Biomarkers ◽  
Diagnostic Usefulness ◽  
Chemiluminescent Microparticle Immunoassay

Background: Stromelysins are potential breast cancer biomarkers. The aim of the study was to evaluate if plasma levels of selected metalloproteinases (MMPs) (stromelysin-1 (MMP-3) and stromelysin-10 (MMP-10)) and cancer antigen 15-3 (CA 15-3) used separately and in combination demonstrated diagnostic usefulness in breast cancer (BC). Methods: The study group consisted of 120 patients with BC, while the control group included 40 patients with benign breast cancer and 40 healthy individuals. Concentrations of MMP-3 and MMP-10 were determined by enzyme-linked immunosorbent assay; CA 15-3 was determined by chemiluminescent microparticle immunoassay. Results: In the group of patients with BC, the area under the curve (AUC) was significantly higher for all markers (except MMP-3) and all sets of markers. At the earliest disease stage, only MMP-10 had a significantly higher AUC (AUC = 0.8692, p < 0.001). Moreover, MMP-10 had the highest AUC (0.9166) among parameters tested separately. The highest AUC was observed for the combination of MMP-10 + CA 15-3 and MMP-3 + MMP-10 + CA 15-3 in line with disease progression (stage I 0.8884 and 0.8906, stage II 0.9244 and 0.9308, stages III + IV 0.9919 and 0.9944, respectively, p < 0.001 in all cases). Conclusions: The results suggest that MMP-10 could be a potential marker in early stages of BC. Moreover, plasma concentration of MMP-10 and MMP-3 in combination with CA 15-3 may improve diagnosis of this type of cancer.

scholarly journals Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis

2014 ◽  
Vol 111 (3) ◽  
pp. 539-550 ◽  
Author(s):  
R Cao ◽  
J Chen ◽  
X Zhang ◽  
Y Zhai ◽  
X Qing ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Aggressiveness ◽  
Elevated Expression ◽  
Myosin X

scholarly journals E2F Activators Signal and Maintain Centrosome Amplification in Breast Cancer Cells

2014 ◽  
Vol 34 (14) ◽  
pp. 2581-2599 ◽  
Author(s):  
M.-Y. Lee ◽  
C. S. Moreno ◽  
H. I. Saavedra
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Centrosome Amplification

scholarly journals Cooperation between monocytes and breast cancer cells promotes factors involved in cancer aggressiveness

2003 ◽  
Vol 88 (8) ◽  
pp. 1207-1212 ◽  
Author(s):  
E Blot ◽  
W Chen ◽  
M Vasse ◽  
J Paysant ◽  
C Denoyelle ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cancer Aggressiveness
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