Analysis of the Role of the Wnt/B-Cantenin Pathway in Prostate Development and Tumorigenesis

2004 ◽  
Author(s):  
Bart O. Williams
Keyword(s):  
Prostate Development

scholarly journals The role of the androgen receptor in prostate development and benign prostatic hyperplasia: A review

2020 ◽  
Vol 7 (3) ◽  
pp. 191-202 ◽  
Author(s):  
Renee E. Vickman ◽  
Omar E. Franco ◽  
Daniel C. Moline ◽  
Donald J. Vander Griend ◽  
Praveen Thumbikat ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Prostate Development

scholarly journals Androgen action in cell fate and communication during prostate development at single-cell resolution

Development ◽  
2020 ◽  
pp. dev.196048
Author(s):  
Dong-Hoon Lee ◽  
Adam W. Olson ◽  
Jinhui Wang ◽  
Won Kyung Kim ◽  
Jiaqi Mi ◽  
...  
Keyword(s):  
Single Cell ◽  
Signaling Pathways ◽  
Cell Fate ◽  
Molecular Mechanisms ◽  
Bud Formation ◽  
Master Regulators ◽  
Prostate Development ◽  
Dynamic Cell ◽  
Cell Signaling Networks

Androgens/androgen receptor (AR) mediated signaling pathways are essential for prostate development, morphogenesis, and regeneration. Specifically, stromal AR-signaling has been shown to be essential for prostatic initiation. However, the molecular mechanisms underlying AR-initiated mesenchymal-epithelial interactions in prostate development remain unclear. Here, using a newly generated mouse model, we directly addressed the fate and role of genetically marked AR-expressing cells during embryonic prostate development. Androgen signaling-initiated signaling pathways were identified in mesenchymal niche populations at single cell transcriptomic resolution. The dynamic cell-signaling networks regulated by stromal AR were characterized in regulating prostatic epithelial bud formation. Pseudotime analyses further revealed the differentiation trajectory and fate of AR-expressing cells in both prostatic mesenchymal and epithelial cell populations. Specifically, the cellular properties of Zeb1-expressing progenitors were assessed. Selective deletion of AR signaling in a subpopulation mesenchymal rather than epithelial cells dysregulates the expression of the master regulators and significantly impairs prostatic bud formation. These data provide novel, high-resolution evidence demonstrating the important role of mesenchymal androgen signaling as cellular niches controlling prostate early development by initiating dynamic mesenchyme-epithelia cell interactions.

scholarly journals The role of Pax2 in mouse prostate development

The Prostate ◽  
2011 ◽  
Vol 72 (2) ◽  
pp. 217-224 ◽  
Author(s):  
Ben Xu ◽  
Arun Hariharan ◽  
Sabita Rakshit ◽  
Gregory R. Dressler ◽  
Deneen M. Wellik
Keyword(s):  
Prostate Development ◽  
Mouse Prostate

scholarly journals Administration of 5α-Androstane-3α,17β-Diol to Female Tammar Wallaby Pouch Young Causes Development of a Mature Prostate and Male Urethra

Endocrinology ◽  
2002 ◽  
Vol 143 (7) ◽  
pp. 2643-2651 ◽  
Author(s):  
Michael W. Leihy ◽  
Geoffrey Shaw ◽  
Marilyn B. Renfree ◽  
Jean D. Wilson
Keyword(s):  
Small Dose ◽  
Tammar Wallaby ◽  
Male Urethra ◽  
Subsequent Growth ◽  
Prostate Development ◽  
Male Type ◽  
Androgen Action ◽  
Time Period ◽  
D 20

Abstract Secretion of 5α-androstane-3α,17β-diol (5α-adiol) by the testes of the tammar wallaby is responsible for initiation of prostatic development after d 20 in male pouch young. To ascertain the role of this hormone in the subsequent growth and differentiation of the prostate and in the development of the male phallus, 5α-adiol was administered to tammar female pouch young in two regimens. Administration of the hormone by mouth (8 μg/g body weight·wk) between d 70 and 150 of pouch life caused prostate development equivalent to that in d 150 males and promoted growth and differentiation of the penis, but not masculinization of the urethra. Treatment with a small dose of 5α-adiol enanthate (1 μg/g body weight·wk) from d 20–150 produced similar results. However, administration of larger doses of 5α-adiol enanthate (10 or 100 μg/g body weight·wk) from d 20–150 caused supraphysiological growth of the prostate, development of a male-type urethra, and penile growth. These results indicate that prostatic development and penile growth can be initiated over a wide time period, but that formation of a male urethra requires androgen action before d 70, when male penile differentiation begins. This further strengthens the hypothesis that 5α-adiol is the circulating androgen responsible in this species for virilization during development.

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