PET Imaging of Breast Cancer Using F-18 Labeled Choline Analogs

2003 ◽  
Author(s):  
Mary S. Soo ◽  
Timothy DeGrado ◽  
Eric L. Rosen ◽  
Tim Turkington ◽  
R. E. Coleman
Keyword(s):  
Breast Cancer ◽  
Pet Imaging ◽  
Choline Analogs

scholarly journals HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging

2018 ◽  
Vol 24 (8) ◽  
pp. 1853-1865 ◽  
Author(s):  
Carlos D. Martins ◽  
Chiara Da Pieve ◽  
Thomas A. Burley ◽  
Rhodri Smith ◽  
Daniela M. Ciobota ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pet Imaging ◽  
Hsp90 Inhibition ◽  
Breast Cancer Xenografts

Abstract PD6-09: Herpet study- PET imaging of HER2 expression in breast cancer using the novel Affibody tracer [18F]GE-226, a first in patient study

2021 ◽  
Author(s):  
Laura M. Kenny ◽  
Gosala S. Gopalakrishnan ◽  
Tara D. Barwick ◽  
Vijay Vaja ◽  
S. Hope McDevitt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pet Imaging ◽  
The Novel ◽  
Her2 Expression ◽  
Patient Study

maxPET, a dedicated mammary and axillary region PET imaging system for breast cancer

2001 ◽  
Vol 48 (3) ◽  
pp. 811-815 ◽  
Author(s):  
N.K. Doshi ◽  
R.W. Silverman ◽  
Y. Shao ◽  
S.R. Cherry
Keyword(s):  
Breast Cancer ◽  
Pet Imaging ◽  
Imaging System ◽  
Axillary Region

scholarly journals HER3 PET Imaging Identifies HER2+ Breast Cancers That Benefit From HER3 Inhibitor Addition  

2020 ◽  
Author(s):  
Eric Wehrenberg-Klee ◽  
Nicoleta Sinevici ◽  
Sarah Nesti ◽  
Taylor Kalomeris ◽  
Emily Austin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Pet Imaging ◽  
Therapeutic Efficacy ◽  
Tumor Escape ◽  
Breast Cancers ◽  
Dynamic Changes ◽  
Modest Improvement ◽  
Her2 Breast Cancer ◽  
Her3 Expression

Abstract Background: Standard therapy for HER2+ breast cancers includes HER2 inhibition. While HER2 inhibitors have modestly improved outcomes, they have not had nearly the original anticipated therapeutic efficacy, with only a modest improvement in survival in both the metastatic and adjuvant setting. An important intrinsic resistance mechanism to HER2 inhibition in some breast cancers is dynamic upregulation of HER3. Increase in HER3 expression that occurs in response to HER2 inhibition allows for continued growth signaling through HER2:HER3 heterodimers, promoting tumor escape. We hypothesized that a non-invasive method to image changes in HER3 expression would be valuable to identify those breast cancers that dynamically upregulate HER3 in response to HER2 inhibition. We further hypothesized that this imaging method could identify those tumors that would benefit by further addition of a HER3 inhibitor. Methods: In cells treated with the HER2 inhibitor lapatinib, we evaluate changes in HER3 expression and viability. Mouse HER2+ breast cancer models treated with lapatinib were imaged with a peptide-based HER3-specific PET imaging agent (Ga-68-HER3P1) to assess for dynamic changes in tumoral HER3 expression and uptake confirmed by biodistribution. Subsequently, HER2+ cell lines were treated with the HER2 inhibitor lapatinib as well HER3-specific siRNA to assess for changes in viability and correlate with HER3 expression upregulation. For all statistical comparisons, p<0.05 was considered statistically significant. Results: Ga68-HER3P1 PET imaging of mice implanted with the HER2+ breast cancer cell lines MDA-MB453 or HCC-1569 prior to and after treatment with lapatinib demonstrated a significant increase in SUV in MDA-MB453 tumors only, consistent with in vitro findings. The addition of HER3 siRNA to lapatinib increased therapeutic efficacy in MDA-MB453 cells, but not in HCC-1569 cells. Conclusion: HER3 PET imaging can be used to visualize dynamic changes in HER3 expression that occur in HER2+ breast cancers with HER2 inhibitor treatment and identify those likely to benefit by the addition of combination HER3 and HER2 inhibition.

Identification of a sodium pump Na + /K + ATPase α1-targeted peptide for PET imaging of breast cancer

2018 ◽  
Vol 281 ◽  
pp. 178-188 ◽  
Author(s):  
Qian Wang ◽  
Shi-Bing Li ◽  
Yi-Ying Zhao ◽  
Da-Nian Dai ◽  
Hui Du ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pet Imaging ◽  
Sodium Pump

Abstract PD6-10:18F-fluoroestradiol (fes) and18f-fluorodeoxyglucose (fdg) pet imaging in metastatic lobular breast cancer

2021 ◽  
Author(s):  
Poorni Manohar ◽  
Lanell Peterson ◽  
Vicky Wu ◽  
Isaac Jenkins ◽  
Mark Muzi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pet Imaging ◽  
Fdg Pet ◽  
Lobular Breast Cancer
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