MTF Computerized Decision Support for Chemical Hazard Emergencies

2003 ◽  
Author(s):  
Warren L. Whitlock
Keyword(s):  
Decision Support ◽  
Computerized Decision Support ◽  
Chemical Hazard

scholarly journals Computer-supported Detection of M-Components and Evaluation of Immunoglobulins after Capillary Electrophoresis

2001 ◽  
Vol 47 (1) ◽  
pp. 110-117 ◽  
Author(s):  
Magnus Jonsson ◽  
Joyce Carlson ◽  
Jan-Olof Jeppsson ◽  
Per Simonsson
Keyword(s):  
Capillary Electrophoresis ◽  
Decision Support ◽  
Protein Separation ◽  
Serum Proteins ◽  
Cost Effective ◽  
Clinical Samples ◽  
Serum Samples ◽  
Computerized Decision Support ◽  
Cost Effective Method ◽  
Mathematical Algorithms

Abstract Background: Electrophoresis of serum samples allows detection of monoclonal gammopathies indicative of multiple myeloma, Waldenström macroglobulinemia, monoclonal gammopathy of undetermined significance, and amyloidosis. Present methods of high-resolution agarose gel electrophoresis (HRAGE) and immunofixation electrophoresis (IFE) are manual and labor-intensive. Capillary zone electrophoresis (CZE) allows rapid automated protein separation and produces digital absorbance data, appropriate as input for a computerized decision support system. Methods: Using the Beckman Paragon CZE 2000 instrument, we analyzed 711 routine clinical samples, including 95 monoclonal components (MCs) and 9 cases of Bence Jones myeloma, in both the CZE and HRAGE systems. Mathematical algorithms developed for the detection of monoclonal immunoglobulins (MCs) in the γ- and β-regions of the electropherogram were tested on the entire material. Additional algorithms evaluating oligoclonality and polyclonal concentrations of immunoglobulins were also tested. Results: CZE electropherograms corresponded well with HRAGE. Only one IgG MC of 1 g/L, visible on HRAGE, was not visible after CZE. Algorithms detected 94 of 95 MCs (98.9%) and 100% of those visible after CZE. Of 607 samples lacking an MC on HRAGE, only 3 were identified by the algorithms (specificity, 99%). Algorithms evaluating total gammaglobulinemia and oligoclonality also identified several cases of Bence Jones myeloma. Conclusions: The use of capillary electrophoresis provides a modern, rapid, and cost-effective method of analyzing serum proteins. The additional option of computerized decision support, which provides rapid and standardized interpretations, should increase the clinical availability and usefulness of protein analyses in the future.

Assessment of education and computerized decision support interventions for improving transfusion practice

Transfusion ◽  
2007 ◽  
Vol 47 (2) ◽  
pp. 228-239 ◽  
Author(s):  
Jeffrey M. Rothschild ◽  
Siobhan McGurk ◽  
Melissa Honour ◽  
Linh Lu ◽  
Aubre A. McClendon ◽  
...  
Keyword(s):  
Decision Support ◽  
Transfusion Practice ◽  
Computerized Decision Support

COMPUTERIZED DECISION SUPPORT SYSTEMS ARE AN EFFECTIVE TOOL FOR THE STANDARDIZATION OF CRITICAL CARE

1995 ◽  
Vol 23 (Supplement) ◽  
pp. A25
Author(s):  
Thomas East ◽  
Alan Morris ◽  
Jane Wallace ◽  
Donna Pope ◽  
Meg Franklin ◽  
...  
Keyword(s):  
Critical Care ◽  
Decision Support ◽  
Decision Support Systems ◽  
Support Systems ◽  
Computerized Decision Support ◽  
Computerized Decision Support Systems
Sign in / Sign up

Export Citation Format

Share Document