Contrast Agents for Breast Cancer Diagnosis by Magnetic Resonance Imaging: Targeting the Folate Receptor

2003 ◽  
Author(s):  
Julian A. Davies
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Cancer Diagnosis ◽  
Folate Receptor ◽  
Breast Cancer Diagnosis ◽  
Resonance Imaging

scholarly journals Contrast-enhanced spectral mammography in the radiological assessment of response to neoadjuvant chemotherapy in breast cancer

2021 ◽  
pp. e521
Author(s):  
Anna Grażyńska ◽  
Sofija Antoniuk ◽  
Katarzyna Steinhof-Radwańska
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Neoadjuvant Chemotherapy ◽  
Residual Disease ◽  
Tumour Size ◽  
Breast Cancer Diagnosis ◽  
Chemotherapy Response ◽  
Resonance Imaging ◽  
Contrast Enhanced

Accurate morphological assessment and measurement of the residual disease following neoadjuvant chemotherapy are vital for the effective surgical treatment in patients with breast cancer. Neoadjuvant chemotherapy response is measured by RECIST 1.1 criteria (Response Evaluation Criteria in Solid Tumors), and the classification of the specific therapeutic responses is based on the difference in the tumour size prior to and after chemotherapy. There are currently a few methods of imaging used in the assessment of the neoadjuvant chemotherapy response. Conventional mammography remains the most popular method, whereas magnetic resonance imaging is considered the most effective ones. Nonetheless, the available methods tend to be imperfect and limited, and therefore, new methods are constantly investigated. Contrast-enhanced spectral mammography is a relatively new method used in breast cancer diagnosis, which involves the phenomenon of neoangiogenesis of cancerous tumours, allowing contrast enhancement in the areas of vessel proliferation in the background of the surrounding breast tissue. Contrast-enhanced spectral mammography presents sensitivity similar to magnetic resonance imaging in breast cancer detection, and can be an efficient method used in monitoring neoadjuvant chemotherapy response.

Facile synthesis of manganese silicate nanoparticles for pH/GSH-responsive T1-weighted magnetic resonance imaging

2016 ◽  
Vol 4 (24) ◽  
pp. 4313-4321 ◽  
Author(s):  
X. W. Li ◽  
W. R. Zhao ◽  
Y. J. Liu ◽  
X. H. Liu ◽  
P. Shi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Cancer Diagnosis ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Facile Synthesis ◽  
Mri Contrast ◽  
Manganese Silicate ◽  
Weighted Magnetic Resonance Imaging

Manganese silicate nanoparticles were facilely synthesized and showed high potential as T1-MRI contrast agents for cancer diagnosis.

Magnetic resonance imaging of tumor vasculature

2003 ◽  
Vol 89 (01) ◽  
pp. 25-33 ◽  
Author(s):  
Maya Chetrit-Dadiani ◽  
Liora Bogin ◽  
Edna Furman-Haran ◽  
Hadassa Degani
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Critical Role ◽  
Tumor Vasculature ◽  
Breast Cancer Diagnosis ◽  
Resonance Imaging ◽  
Tissue Water ◽  
Magnetic Resonance Imaging Mri ◽  
Tumor Growth And Metastasis

SummaryAngiogenic activity and formation of a vascular network facilitate tumor perfusion and play a critical role in tumor growth and metastasis. Tumor vasculature may be visualized by means of parametric imaging of specific morphological and physiological characteristics that collectively describe its properties. In this review, we describe advanced magnetic resonance imaging (MRI) techniques that have been developed in order to image and quantify the distribution of tumor vasculature throughout the tumor and characterize its function. These techniques have been used to monitor changes in the magnetic resonance signal intensity of tissue water hydrogens generated by intrinsic effects, as well as by exogenous contrast agents administered into the blood circulation. We further describe specific applications of magnetic resonance imaging using a contrast agent, gadolinium diethylene triamine penta-acetic acid (GdDTPA), which has long been approved for clinical use. Examples include studies of the vascular properties of breast cancer tumors and metastases in animal models, as well as of breast cancer vasculature in patients. We also discuss the use of MRI to improve breast cancer diagnosis in humans by quantifying the permeability of the tumor vasculature. By maximizing the spatial resolution of the images in both animal and human studies, the capacity of magnetic resonance imaging to enhance our understanding of the processes regulating tumor angio-genesis, and improve the diagnosis of cancer, could be clearly demonstrated.

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