Transcriptional Regulation of VEGF Expression in Breast Cancer

2003 ◽  
Author(s):  
Sebastian Bredow
Keyword(s):  
Breast Cancer ◽  
Transcriptional Regulation ◽  
Vegf Expression

scholarly journals Integrated transcription factor profiling with transcriptome analysis identifies L1PA2 transposons as global regulatory modulators in a breast cancer model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jiayue-Clara Jiang ◽  
Joseph A. Rothnagel ◽  
Kyle R. Upton
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Transcriptional Regulation ◽  
Disease Diagnosis ◽  
Integrated Analysis ◽  
Regulatory Sequences ◽  
Cancer Model ◽  
Mcf7 Cells ◽  
Epithelial Cancers ◽  
Breast Cancer Model

AbstractWhile transposons are generally silenced in somatic tissues, many transposons escape epigenetic repression in epithelial cancers, become transcriptionally active and contribute to the regulation of human gene expression. We have developed a bioinformatic pipeline for the integrated analysis of transcription factor binding and transcriptomic data to identify transposon-derived promoters that are activated in specific diseases and developmental states. We applied this pipeline to a breast cancer model, and found that the L1PA2 transposon subfamily contributes abundant regulatory sequences to co-ordinated transcriptional regulation in breast cancer. Transcription factor profiling demonstrates that over 27% of L1PA2 transposons harbour co-localised binding sites of functionally interacting, cancer-associated transcription factors in MCF7 cells, a cell line used to model breast cancer. Transcriptomic analysis reveals that L1PA2 transposons also contribute transcription start sites to up-regulated transcripts in MCF7 cells, including some transcripts with established oncogenic properties. In addition, we verified the utility of our pipeline on other transposon subfamilies, as well as on leukemia and lung carcinoma cell lines. We demonstrate that the normally quiescent regulatory activities of transposons can be activated and alter the cancer transcriptome. In particular, the L1PA2 subfamily contributes abundant regulatory sequences, and likely plays a global role in modulating breast cancer transcriptional regulation. Understanding the regulatory impact of L1PA2 on breast cancer genomes provides additional insights into cancer genome regulation, and may provide novel biomarkers for disease diagnosis, prognosis and therapy.

scholarly journals Transcriptional regulation of mixed lineage kinase 3 by estrogen and its implication in ER-positive breast cancer pathogenesis

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 33172-33184 ◽  
Author(s):  
Navin Viswakarma ◽  
Rakesh Sathish Nair ◽  
Gautam Sondarva ◽  
Subhasis Das ◽  
Lucas Ibrahimi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcriptional Regulation ◽  
Mixed Lineage Kinase ◽  
Cancer Pathogenesis ◽  
Er Positive ◽  
Mixed Lineage Kinase 3 ◽  
Positive Breast Cancer

Effects of the Lifestyle Habits in Breast Cancer Transcriptional Regulation

2020 ◽  
Author(s):  
Marco Allán Pérez-Solis ◽  
Guadalupe Maya-Nuñez ◽  
Patricia Casas-González ◽  
Aleida Olivares ◽  
Arturo Aguilar-Rojas
Keyword(s):  
Breast Cancer ◽  
Transcriptional Regulation ◽  
Lifestyle Habits

scholarly journals Essential role of MED1 in the transcriptional regulation of ER-dependent oncogenic miRNAs in breast cancer

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Neha Nagpal ◽  
Shivani Sharma ◽  
Sourobh Maji ◽  
Giorgio Durante ◽  
Manuela Ferracin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcriptional Regulation ◽  
Essential Role ◽  
Oncogenic Mirnas

VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer

2006 ◽  
Vol 14 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Dora Fuckar ◽  
Andrea Dekanic ◽  
Sanja Stifter ◽  
Elvira Mustac ◽  
Mira Krstulja ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptor Status ◽  
Vegf Expression ◽  
Receptor Status ◽  
Negative Estrogen Receptor Status
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