The Role of Clusterin in Estrogen Deprivation-Mediated Cell Death in Breast Cancer Cells

2002 ◽  
Author(s):  
Konstantin S. Leskov ◽  
David A. Boothman
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Deprivation

scholarly journals Role of p53/p21Waf1/Cip1 in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells

2005 ◽  
Vol 4 (9) ◽  
pp. 1006-1013 ◽  
Author(s):  
Yi Huang ◽  
Allison Pledgie ◽  
Ethel Rubin ◽  
Laurence J. Marton ◽  
Patrick M. Woster ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Polyamine Analogue

scholarly journals The role of individual caspases in cell death induction by taxanes in breast cancer cells

2015 ◽  
Vol 15 (1) ◽  
pp. 8 ◽  
Author(s):  
Michael Jelínek ◽  
Kamila Balušíková ◽  
Martina Schmiedlová ◽  
Vlasta Němcová-Fürstová ◽  
Jan Šrámek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Breast Cancer Cells

scholarly journals Circadian Rhythms and Breast Cancer: The Role of Per2 in Doxorubicin-Induced Cell Death

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Megan I. Mitchell ◽  
Anna-Mart Engelbrecht
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Circadian Rhythms ◽  
Cancer Cells ◽  
Cell Lines ◽  
Breast Cancer Cells ◽  
Normal Breast ◽  
Cytotoxic Effects ◽  
Downstream Effects

Mammalian circadian rhythms form an integral physiological system allowing for the synchronisation of all metabolic processes to daily light/dark cycles, thereby optimising their efficacy. Circadian disruptions have been implicated in the onset and progression of various cancers, including those arising in the breast. Several links between the circadian protein Per2 and DNA damage responses exist. Aberrant Per2 expression results in potent downstream effects on both cell cycle and apoptotic targets, suggestive of a tumour suppressive role for Per2. Due to the severe dose limiting side effects associated with current chemotherapeutic strategies, including the use of doxorubicin, a need for more effective adjuvant therapies to increase cancer cell susceptibility has arisen. This study was therefore aimed at characterizing the role of Per2 in normal breast epithelia (MCF-12A) and in ER−breast cancer cells (MDA-MB-231) and also at determining the role of Per2 in doxorubicin-induced cell death. In both cell lines Per2 protein expression displayed a 24-hour circadian rhythm in both cell lines. Per2 was located predominantly in the cytoplasm, with nuclear localization observed with lower cytoplasmic fluorescent intensities. Our results show that Per2 silencing effectively sensitizes the chemoresistant MDA-MB-231 breast cancer cells to the cytotoxic effects of doxorubicin.

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