Bio-Available Iron in Breast Cancer of Older Women

2002 ◽  
Author(s):  
Xi Huang ◽  
Arslan Akhmedkhanov ◽  
Anne Zeleniuch-Jaquotte ◽  
M. A. Ali ◽  
Juliana Powell
Keyword(s):  
Breast Cancer ◽  
Older Women

Follow-Up Care for Older Women With Breast Cancer

1998 ◽  
Author(s):  
Sherrie H. Kaplan ◽  
Rebecca A. Silliman
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Follow Up Care

Effect of chemotherapy on default mode network connectivity in older women with breast cancer

2021 ◽  
Author(s):  
Bihong T. Chen ◽  
Zikuan Chen ◽  
Sunita K. Patel ◽  
Russell C. Rockne ◽  
Chi Wah Wong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Default Mode Network ◽  
Network Connectivity ◽  
Default Mode

scholarly journals Genomic Risk Prediction for Breast Cancer in Older Women

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3533
Author(s):  
Paul Lacaze ◽  
Andrew Bakshi ◽  
Moeen Riaz ◽  
Suzanne G. Orchard ◽  
Jane Tiller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Risk Prediction ◽  
Prediction Models ◽  
Cox Regression ◽  
Susceptibility Genes ◽  
Controlled Clinical Trial ◽  
Polygenic Risk Score ◽  
Double Blind ◽  
Genomic Risk

Genomic risk prediction models for breast cancer (BC) have been predominantly developed with data from women aged 40–69 years. Prospective studies of older women aged ≥70 years have been limited. We assessed the effect of a 313-variant polygenic risk score (PRS) for BC in 6339 older women aged ≥70 years (mean age 75 years) enrolled into the ASPREE trial, a randomized double-blind placebo-controlled clinical trial investigating the effect of daily 100 mg aspirin on disability-free survival. We evaluated incident BC diagnoses over a median follow-up time of 4.7 years. A multivariable Cox regression model including conventional BC risk factors was applied to prospective data, and re-evaluated after adding the PRS. We also assessed the association of rare pathogenic variants (PVs) in BC susceptibility genes (BRCA1/BRCA2/PALB2/CHEK2/ATM). The PRS, as a continuous variable, was an independent predictor of incident BC (hazard ratio (HR) per standard deviation (SD) = 1.4, 95% confidence interval (CI) 1.3–1.6) and hormone receptor (ER/PR)-positive disease (HR = 1.5 (CI 1.2–1.9)). Women in the top quintile of the PRS distribution had over two-fold higher risk of BC than women in the lowest quintile (HR = 2.2 (CI 1.2–3.9)). The concordance index of the model without the PRS was 0.62 (95% CI 0.56–0.68), which improved after addition of the PRS to 0.65 (95% CI 0.59–0.71). Among 41 (0.6%) carriers of PVs in BC susceptibility genes, we observed no incident BC diagnoses. Our study demonstrates that a PRS predicts incident BC risk in women aged 70 years and older, suggesting potential clinical utility extends to this older age group.

The impact of cognitive impairment on survival and medication adherence among older women with breast cancer

Breast Cancer ◽  
2020 ◽  
Author(s):  
Yasser Alatawi ◽  
Richard A. Hansen ◽  
Chiahung Chou ◽  
Jingjing Qian ◽  
Vishnu Suppiramaniam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cognitive Impairment ◽  
Medication Adherence ◽  
Older Women ◽  
The Impact

scholarly journals Local Therapy Decisional Regret in Older Women With Breast Cancer: A Population-Based Study

2019 ◽  
Vol 104 (2) ◽  
pp. 383-391 ◽  
Author(s):  
Pragati G. Advani ◽  
Xiudong Lei ◽  
Cameron W. Swanick ◽  
Ying Xu ◽  
Yu Shen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Local Therapy ◽  
Population Based ◽  
Population Based Study ◽  
Decisional Regret
Sign in / Sign up

Export Citation Format

Share Document