Cell Cycle Regulation in Prostate Cancer and its Role in the Transition of Androgen-Dependent Prostate Cancer to Androgen-Independency

2001 ◽  
Author(s):  
Anita Frijhoff
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Cycle Regulation

Abstract 1766: Effect of soy isoflavones on prostate cancer cell cycle regulation and apoptosis

2010 ◽  
Author(s):  
Peter J. Van Veldhuizen ◽  
Anup Kasi Loknath Kumar ◽  
Snigdha Banerjee ◽  
Gophal Dhar ◽  
Smita Mehta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cancer Cell ◽  
Cell Cycle Regulation ◽  
Prostate Cancer Cell ◽  
Soy Isoflavones ◽  
Cycle Regulation

scholarly journals GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer

2019 ◽  
Vol 146 (5) ◽  
pp. 1369-1382 ◽  
Author(s):  
Yuichiro Sawada ◽  
Tadahiko Kikugawa ◽  
Hiroyuki Iio ◽  
Iori Sakakibara ◽  
Shuhei Yoshida ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Bone Metastasis ◽  
Cell Cycle Regulation ◽  
Cycle Regulation

Abstract 2358: Impact of MDM2 inhibition on cell cycle regulation through Aurora Kinase B - CDK1 axis in prostate cancer cells

2017 ◽  
Author(s):  
Thanigaivelan Kanagasabai ◽  
Khalid Alhazzani ◽  
Thiagarajan Venkatesan ◽  
Sivanesan Dhandayuthapani ◽  
Ali Alaseem ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Cell Cycle Regulation ◽  
Aurora Kinase ◽  
Prostate Cancer Cells ◽  
Aurora Kinase B ◽  
Cycle Regulation

Genomic diversity between primary tumor tissue and tumor circulating cell-free DNA (cfDNA) in patients (pts) with metastatic prostate cancer.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 189-189 ◽  
Author(s):  
Emma Carroll ◽  
David Michael Gill ◽  
Austin Poole ◽  
Andrew W. Hahn ◽  
Erin B. Bailey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Dna Repair ◽  
Cell Cycle Regulation ◽  
Metastatic Prostate Cancer ◽  
Tumor Tissue ◽  
Treatment Selection ◽  
Number Of Patients ◽  
The Mean ◽  
Cycle Regulation

189 Background: Tumor tissue and tumor cfDNA next-generation sequencing (NGS) tests are obtained in pts with metastatic prostate cancer and have demonstrated a diverse genomic landscape. High-level evidence does not exist for utilizing these tests to guide treatment selection in these pts. Targeted therapies are available for metastatic prostate cancer treatment and clinical trials are investigating drugs targeting specific molecular pathways. The objective of this study was to assess type and number of genomic aberrations between tumor tissue and cfDNA. Methods: Pts with metastatic prostate cancer who had both tissue and cfDNA results were selected and genomic profiles were compared between these two technologies. The mean number of tissue mutations was compared to cfDNA mutations for all pts using the t-test. The mutations for both tests were then categorized into five pathways: DNA repair, cell cycle regulation, PI3K, epigenetics, and androgen receptor (AR). For each pathway, the total number of patients with a mutation was compared between tissue and cfDNA using the Mann-Whitney test. Results: Nineteen pts were identified with both tissue and cfDNA results. The mean number of mutations identified was significantly less with cfDNA (95% CI, 2.7-5.3) compared to tissue (95% CI, 7.0-9.7; P < 0.0001). There were significantly more patients with PI3K pathway mutations identified in the tissue compared to cfDNA (73.7% vs 21.1% P = 0.0018), as well as epigenetic mutations (47.4% vs 0.0% P = 0.0012). There was no difference in the number of patients identified to have DNA repair, cell cycle regulation, and AR variances between the two tests. Conclusions: The lower number of aberrations detected by the cfDNA test may have occurred due to lower sensitivity of cfDNA compared to tissue based NGS. Discordance in the type of genomic variances between the two tests suggests intra-individual genetic diversity, and these results may have implications in treatment selection of pts with metastatic prostate cancer. Data are hypothesis generating and need further investigation in a larger cohort.

The Tumor Suppressor Gene PTEN Plays a Role in Cell Cycle Regulation and Apoptosis in Prostate Cancer Cell Lines

2006 ◽  
pp. 487-493
Author(s):  
Alice Hlobilková ◽  
Michaela Šváchová ◽  
Jana Knillová ◽  
Eva Pimrová ◽  
Petra Řiháková ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cell Cycle Regulation ◽  
Suppressor Gene ◽  
Prostate Cancer Cell Lines ◽  
Cycle Regulation
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