Natural History of Vestibular Schwannomas in Neurofibromatosis Type 2 (NF2)

2002 ◽  
Author(s):  
William H. Slattery ◽  
III
Keyword(s):  
Natural History ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Vestibular Schwannomas ◽  
History Of

Natural history of neurofibromatosis type 2 with onset before the age of 1 year

Neurogenetics ◽  
2013 ◽  
Vol 14 (2) ◽  
pp. 89-98 ◽  
Author(s):  
Martino Ruggieri ◽  
Anna Lia Gabriele ◽  
Agata Polizzi ◽  
Vincenzo Salpietro ◽  
Francesco Nicita ◽  
...  
Keyword(s):  
Natural History ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
History Of

scholarly journals Natural History of Vestibular Schwannoma Growth and Hearing Decline in Newly Diagnosed Neurofibromatosis Type 2 Patients

2014 ◽  
Vol 35 (1) ◽  
pp. e50-e56 ◽  
Author(s):  
Scott R. Plotkin ◽  
Vanessa L. Merker ◽  
Alona Muzikansky ◽  
Fred G. Barker ◽  
William Slattery
Keyword(s):  
Natural History ◽  
Vestibular Schwannoma ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Newly Diagnosed ◽  
History Of

Variations and natural history of primary intraparenchymal lesions associated with neurofibromatosis type 2

2021 ◽  
Author(s):  
Yukitomo Ishi ◽  
Taisuke Harada ◽  
Hiroyuki Kameda ◽  
Hiromi Okada ◽  
Isao Yokota ◽  
...  
Keyword(s):  
Natural History ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
History Of

Earliest Clinical Manifestations and Natural History of Neurofibromatosis Type 2 (NF2) in Childhood: A Study of 24 Patients

2005 ◽  
Vol 36 (1) ◽  
pp. 21-34 ◽  
Author(s):  
M. Ruggieri ◽  
P. Iannetti ◽  
A. Polizzi ◽  
I. La Mantia ◽  
A. Spalice ◽  
...  
Keyword(s):  
Natural History ◽  
Clinical Manifestations ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
History Of

scholarly journals Audiologic Natural History of Small Volume Cochleovestibular Schwannomas in Neurofibromatosis Type 2

2018 ◽  
Vol 39 (3) ◽  
pp. 357-364
Author(s):  
Alvin T. deTorres ◽  
Carmen C. Brewer ◽  
Chris K. Zalewski ◽  
Kelly A. King ◽  
Robert Walker ◽  
...  
Keyword(s):  
Natural History ◽  
Small Volume ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
History Of

scholarly journals Long-term natural history of neurofibromatosis Type 2–associated intracranial tumors

2012 ◽  
Vol 117 (1) ◽  
pp. 109-117 ◽  
Author(s):  
Michael S. Dirks ◽  
John A. Butman ◽  
H. Jeffrey Kim ◽  
Tianxia Wu ◽  
Keaton Morgan ◽  
...  
Keyword(s):  
Growth Rate ◽  
Natural History ◽  
Growth Pattern ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Intracranial Tumors ◽  
History Of

Object Neurofibromatosis Type 2 (NF2) is a heritable tumor predisposition syndrome that leads to the development of multiple intracranial tumors, including meningiomas and schwannomas. Because the natural history of these tumors has not been determined, their optimal management has not been established. To define the natural history of NF2-associated intracranial tumors and to optimize management strategies, the authors evaluated long-term clinical and radiographic data in patients with NF2. Methods Consecutive NF2 patients with a minimum of 4 years of serial clinical and MRI follow-up were analyzed. Results Seventeen patients, 9 males and 8 females, were included in this analysis (mean follow-up 9.5 ± 4.8 years, range 4.0–20.7 years). The mean age at initial evaluation was 33.2 ± 15.5 years (range 12.3–57.6 years). Patients harbored 182 intracranial neoplasms, 164 of which were assessable for growth rate analysis (18 vestibular schwannomas [VSs], 11 nonvestibular cranial nerve [CN] schwannomas, and 135 meningiomas) and 152 of which were assessable for growth pattern analysis (15 VSs, 9 nonvestibular CN schwannomas, and 128 meningiomas). New tumors developed in patients over the course of the imaging follow-up: 66 meningiomas, 2 VSs, and 2 nonvestibular CN schwannomas. Overall, 45 tumors (29.6%) exhibited linear growth, 17 tumors (11.2%) exhibited exponential growth, and 90 tumors (59.2%) displayed a saltatory growth pattern characterized by alternating periods of growth and quiescence (mean quiescent period 2.3 ± 2.1 years, range 0.4–11.7 years). Further, the saltatory pattern was the most frequently identified growth pattern for each tumor type: meningiomas 60.9%, VSs 46.7%, and nonvestibular schwannoma 55.6%. A younger age at the onset of NF2-related symptoms (p = 0.01) and female sex (p = 0.05) were associated with an increased growth rate in meningiomas. The identification of saltatory growth in meningiomas increased with the duration of follow-up (p = 0.01). Conclusions Neurofibromatosis Type 2–associated intracranial tumors most frequently demonstrated a saltatory growth pattern. Because new tumors can develop in NF2 patients over their lifetime and because radiographic progression and symptom formation are unpredictable, resection may be best reserved for symptom-producing tumors. Moreover, establishing the efficacy of nonsurgical therapeutic interventions must be based on long-term follow-up (several years).

Surgical Management of Vestibular Schwannomas in Neurofibromatosis Type 2

2012 ◽  
Vol 73 (S 02) ◽  
Author(s):  
J. Tysome ◽  
R. MacFarlane ◽  
J. Durie-Gair ◽  
N. Donnelly ◽  
R. Mannion ◽  
...  
Keyword(s):  
Surgical Management ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Vestibular Schwannomas
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