War Syndromes from 1900 to the Present: Symptom Patterns and Longterm Health Outcomes

Novel discoveries in genomics and other omics sciences are rapidly redefining our understanding of health and disease as well as advancing the development of targeted therapeutics for improving health outcomes. The scale of these findings, fueled by vast increases in computing power and new techniques in data analytics, easily supersedes that of phenomena observed using more traditional research approaches. Until recently, the classification and diagnosis of disease has involved rather subjective processes, whereby signs and late symptom patterns are linked with clinical outcomes. However, symptom patterns, disease trajectories, and health outcomes are complex entities characterized by a wide range of clinical manifestations and progression patterns. The burgeoning fields of data science and bioinformatics are opening opportunities for nurse scientists to quantify disease heterogeneity by defining and categorizing disease phenotypes and endotypes. Nurse scientists and clinicians can play a critical role in engaging patients and the larger scientific community in these efforts. The purpose of this article is to provide an introduction to concepts critical to understanding and quantifying heterogeneity in the onset and progression of chronic disease. To present and exemplify key concepts, we (1) discuss evidence for heterogeneity in the onset and progression of Type 1 diabetes, (2) link emerging research approaches in data science with principles in network science and systems biology to lay the groundwork for stratifying subclinical and advanced chronic disease, thus expanding the purview of symptom science, and (3) describe the computational skills needed to engage in these analyses.

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Chronic Pain: Fundamental Scientific Considerations, Specifically for Legal Claims

Guides Newsletter ◽

10.1001/amaguidesnewsletters.2013.janfeb01 ◽

2013 ◽

Vol 18 (1) ◽

pp. 1-18 ◽

Cited By ~ 1

Author(s):

Robert J. Barth

Keyword(s):

Health Outcomes ◽

Pain Perception ◽

Driving Forces ◽

Psychological Treatment ◽

Dominant Role ◽

Meta Analysis ◽

General Medicine ◽

Pain Syndrome ◽

Problematic Relationship

Abstract Scientific findings have indicated that psychological and social factors are the driving forces behind most chronic benign pain presentations, especially in a claim context, and are relevant to at least three of the AMA Guides publications: AMA Guides to Evaluation of Disease and Injury Causation, AMA Guides to Work Ability and Return to Work, and AMA Guides to the Evaluation of Permanent Impairment. The author reviews and summarizes studies that have identified the dominant role of financial, psychological, and other non–general medicine factors in patients who report low back pain. For example, one meta-analysis found that compensation results in an increase in pain perception and a reduction in the ability to benefit from medical and psychological treatment. Other studies have found a correlation between the level of compensation and health outcomes (greater compensation is associated with worse outcomes), and legal systems that discourage compensation for pain produce better health outcomes. One study found that, among persons with carpal tunnel syndrome, claimants had worse outcomes than nonclaimants despite receiving more treatment; another examined the problematic relationship between complex regional pain syndrome (CRPS) and compensation and found that cases of CRPS are dominated by legal claims, a disparity that highlights the dominant role of compensation. Workers’ compensation claimants are almost never evaluated for personality disorders or mental illness. The article concludes with recommendations that evaluators can consider in individual cases.

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Abstract #805855: Testosterone-to-Estradiol Ratio is a More Precise Marker of Health Outcomes in Males Than Testosterone or Estradiol Alone

Endocrine Practice ◽

10.1016/s1530-891x(20)39653-1 ◽

2020 ◽

Vol 26 ◽

pp. 189

Author(s):

Flavio Cadegiani

Keyword(s):

Health Outcomes

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Abstract #282 Diabetes Care, Economics and Health Outcomes: Experiences from the 3 Decade Free Diabetes Clinic for the Poor

Endocrine Practice ◽

10.1016/s1530-891x(20)46626-1 ◽

2019 ◽

Vol 25 ◽

pp. 113-114

Author(s):

Nidhi Garg ◽

Muralidhara Krishna ◽

Madhumati S. Vaishnav ◽

Vasanthi Nath ◽

S. Chandraprabha ◽

...

Keyword(s):

Health Outcomes ◽

Diabetes Care ◽

Diabetes Clinic ◽

The Poor

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Mental Health Among Adolescents from Returned Portuguese Immigrant Families

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000015 ◽

2010 ◽

Vol 69 (3) ◽

pp. 131-139 ◽

Cited By ~ 5

Author(s):

Félix Neto

Keyword(s):

Mental Health ◽

Health Outcomes ◽

Mental Health Problems ◽

Immigrant Families ◽

Health Problems ◽

Mental Health Outcomes ◽

Control Group ◽

Older Adolescents ◽

The Mean ◽

Portuguese Adolescents

This study investigated mental health problems and their predictors among adolescents from returned immigrant families. The sample consisted of 360 returned adolescents (mean age = 16.8 years; SD = 1.9). The mean duration of a sojourn in Portugal for the sample was 8.2 years (SD = 4.5). A control group of 217 Portuguese youths were also included in the study. Adolescents from immigrant families reported mental health levels similar to those of Portuguese adolescents who have never migrated. Girls showed more mental health problems than boys. Younger adolescents showed fewer mental health problems than older adolescents. Adaptation variables contributed to mental health outcomes even after acculturation variables were accounted for. Implications of the study for counselors are discussed.

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