The Use of Her2/neu-Specific Genetic Vaccines for the Prevention and Treatment of Breast Cancer

2000 ◽  
Author(s):  
Roland Tisch
Keyword(s):  
Breast Cancer ◽  
Prevention And Treatment

scholarly journals Yanghe Huayan decoction inhibits the capability of trans-endothelium and angiogenesis of HER2+ breast cancer via pAkt signaling

2019 ◽  
Vol 39 (2) ◽  
Author(s):  
Xiao-Fei Liu ◽  
Jing-Wei Li ◽  
Hong-Zhi Chen ◽  
Zi-Yuan Sun ◽  
Guang-Xi Shi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Medicine ◽  
Precancerous Lesion ◽  
Tumor Development ◽  
Akt Activation ◽  
Her2 Breast Cancer ◽  
Prevention And Treatment

Abstract Background: Yanghe Huayan Decoction (YHD), a traditional Chinese medicine, is one of the most common complementary medicine currently used in the treatment of breast cancer (BC). It has been recently linked to suppress precancerous lesion and tumor development. The current study sought to explore the role of YHD on trans-endothelium and angiogenesis of BC. Methods: HER2+ BC cells were treated with YHD, Trastuzumab, or the combination in vitro and in vivo to compare the effects of them on trans-endothelium and angiogenesis features. The present study also investigated the potential molecular mechanism of YHD in inhibiting angiogenesis of BC. Results: YHD significantly suppressed the invasion and angiogenesis of BC cells via elevated pAkt signaling. Administration of YHD in vivo also strikingly repressed angiogenesis in tumor grafts. Conclusion: YHD could partially inhibit and reverse tumorigenesis of BC. It also could inhibit Akt activation and angiogenesis in vitro and in vivo. Its effect was superior to trastuzumab. Thus it was suitable for prevention and treatment of BC.

scholarly journals Prevention and Treatment of Radiation Induced Skin Damage in Breast Cancer

2014 ◽  
Vol 04 (01) ◽  
pp. 16-23
Author(s):  
Rossella Di Franco ◽  
Vincenzo Ravo ◽  
Sara Falivene ◽  
Angela Argenone ◽  
Valentina Borzillo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Skin Damage ◽  
Prevention And Treatment ◽  
Radiation Induced

scholarly journals d-Limonene: a bioactive food component from citrus and evidence for a potential role in breast cancer prevention and treatment

2011 ◽  
pp. 31-42
Author(s):  
Jessica A. Miller ◽  
Patricia A. Thompson ◽  
Iman A. Hakim ◽  
H.-H. Sherry Chow ◽  
Cynthia A. Thomson
Keyword(s):  
Breast Cancer ◽  
Cancer Prevention ◽  
Immune Modulation ◽  
Wide Spectrum ◽  
Perillyl Alcohol ◽  
Potent Effect ◽  
Food Component ◽  
Citrus Peel ◽  
Anti Cancer ◽  
Prevention And Treatment

Although limited, observations from cell culture, animal, and epidemiological studies support the presence of anti-cancer properties in citrus peel and the primary bioactive food constituent, d-limonene. Early evidence from animal models suggests that when ingested, d-limonene exhibits a wide spectrum of biologic activity including chemotherapeutic and chemopreventive effects. In some of these early models, an analog of d-limonene, perillyl alcohol, demonstrated a more potent effect than d-limonene itself. Yet, when perillyl alcohol advanced to clinical trials, several trials were ended early due to doselimiting toxicities. Alternatively, oral d-limonene administration in humans is well tolerated even at high doses supporting its investigation as a potential bioactive for cancer prevention. Though the exact mechanisms of action of d-limonene are unclear, immune modulation and antiproliferative effects are commonly reported. Here, we review the pre-clinical evidence for d-limonene’s anticancer mechanisms, bioavailability, and safety, as well as the evidence for anti-cancer effects in humans, focusing on studies relevant to its use in the prevention and treatment of breast cancer.

Use of potential dietary phytochemicals to target miRNA: Promising option for breast cancer prevention and treatment?

2017 ◽  
Vol 28 ◽  
pp. 177-193 ◽  
Author(s):  
Md. Abu Sayeed ◽  
Massimo Bracci ◽  
Raffaella Lazzarini ◽  
Marco Tomasetti ◽  
Monica Amati ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Prevention ◽  
Breast Cancer Prevention ◽  
Prevention And Treatment ◽  
Dietary Phytochemicals

Prevalence of BRCA1/BRCA2 pathogenic variation in Chinese Han population

2020 ◽  
pp. jmedgenet-2020-106970 ◽  
Author(s):  
Hui Dong ◽  
Khyati Chandratre ◽  
Yue Qin ◽  
Jing Zhang ◽  
Xiaoqing Tian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hereditary Breast Cancer ◽  
Chinese Population ◽  
Chinese Han Population ◽  
Basic Knowledge ◽  
Chinese Han ◽  
Han Population ◽  
Pathogenic Variation ◽  
Prevention And Treatment ◽  
Brca1 Brca2

BackgroundPathogenic variation in BRCA1 and BRCA2 (BRCA) is one of the most frequent genetic predispositions for hereditary breast cancer. The identification of the variant carriers plays an important role in prevention and treatment of cancer. Despite a population size of 1.4 billion and a quarter million annual new breast cancer cases, knowledge regarding the prevalence of BRCA variation in the Chinese population remains elusive.MethodsIn this study, we used BRCA-targeted sequencing and bioinformatics approaches to screen for BRCA variants in 11 386 Chinese Han individuals, including 9331 females and 2055 males.ResultsWe identified 1209 BRCA variants, 34 of which were pathogenic, including 11 in BRCA1 and 23 in BRCA2. These variants were distributed among 43 individuals (37 females and 6 males), with 13 carrying BRCA1 and 30 carrying BRCA2 variants. Based on these data, we determined a prevalence of 0.38%, or 1 carrier of a BRCA pathogenic variant out of every 265 Chinese Han individuals, and 5.1 million carriers among the Chinese Han population of 1.3 billion.ConclusionOur study provides basic knowledge about the prevalence of BRCA pathogenic variation in the Chinese Han population. This information should be valuable for BRCA-related cancer prevention and treatment in the population.

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