Use of the HSP 110 Peptide Binding Protein for the Development of New Breast Cancer Vaccines

2000 ◽  
Author(s):  
John Subjeck
Keyword(s):  
Breast Cancer ◽  
Cancer Vaccines ◽  
Binding Protein ◽  
Peptide Binding

Towards Breast Cancer Vaccines, Progress and Challenges

2019 ◽  
Vol 16 (3) ◽  
pp. 251-258 ◽  
Author(s):  
Javad Behravan ◽  
Atefeh Razazan ◽  
Ghazal Behravan
Keyword(s):  
Breast Cancer ◽  
Adverse Effects ◽  
Cancer Vaccine ◽  
Cancer Vaccines ◽  
Weight Control ◽  
The Body ◽  
Phase Iii ◽  
Current Therapy ◽  
Surgical Ablation ◽  
Breast Cancer Vaccine

Breast cancer is the second leading cause of cancer death among women. National cancer institute of the US estimates that one in eight women will be diagnosed with breast cancer during their lifetime. Considering the devastating effects of the disease and the alarming numbers many scientists and research groups have devoted their research to fight breast cancer. Several recommendations are to be considered as preventing measures which include living a healthy lifestyle, regular physical activity, weight control and smoking cessation. Early detection of the disease by annual and regular mammography after the age of 40 is recommended by many healthcare institutions. This would help the diagnosis of the disease at an earlier stage and the start of the treatment before it is spread to other parts of the body. Current therapy for breast cancer includes surgical ablation, radiotherapy and chemotherapy which is often associated with adverse effects and even may lead to a relapse of the disease at a later stage. In order to achieve a long-lasting anticancer response with minimal adverse effects, development of breast cancer vaccines is under investigation by many laboratories. The immune system can be stimulated by a vaccine against breast cancer. This approach has attracted a great enthusiasm in recent years. No breast cancer vaccines have been approved for clinical use today. One breast cancer vaccine (NeuVax) has now completed clinical trial phase III and a few preventive and therapeutic breast cancer vaccines are at different steps of development. We think that with the recent advancements in immunotherapy, a breast cancer vaccine is not far from reach.

scholarly journals The RNA-Binding Protein Musashi-1 Regulates Proteasome Subunit Expression in Breast Cancer- and Glioma-Initiating Cells

Stem Cells ◽  
2014 ◽  
Vol 32 (1) ◽  
pp. 135-144 ◽  
Author(s):  
Chann Lagadec ◽  
Erina Vlashi ◽  
Patricia Frohnen ◽  
Yazeed Alhiyari ◽  
Mabel Chan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Proteasome Subunit ◽  
Glioma Initiating Cells ◽  
Subunit Expression
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