Jackson Hole, Wyoming Environmental Restoration Feasibility Report. Volume 2. Appendixes C-I

2000 ◽  
Author(s):  
HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
Keyword(s):  
Environmental Restoration ◽  
Jackson Hole

scholarly journals Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Maya Spichal ◽  
Bree Heestand ◽  
Katherine Kretovich Billmyre ◽  
Stephen Frenk ◽  
Craig C. Mello ◽  
...  
Keyword(s):  
Dna Damage ◽  
Genomic Instability ◽  
Environmental Restoration ◽  
Related Gene ◽  
C Elegans ◽  
Dna Damage Signaling ◽  
Multiple Phenotypes ◽  
Granule Structure ◽  
Germ Granules ◽  
Late Generation

AbstractIn several species, Piwi/piRNA genome silencing defects cause immediate sterility that correlates with transposon expression and transposon-induced genomic instability. In C. elegans, mutations in the Piwi-related gene (prg-1) and other piRNA deficient mutants cause a transgenerational decline in fertility over a period of several generations. Here we show that the sterility of late generation piRNA mutants correlates poorly with increases in DNA damage signaling. Instead, sterile individuals consistently exhibit altered perinuclear germ granules. We show that disruption of germ granules does not activate transposon expression but induces multiple phenotypes found in sterile prg-1 pathway mutants. Furthermore, loss of the germ granule component pgl-1 enhances prg-1 mutant infertility. Environmental restoration of germ granule function for sterile pgl-1 mutants restores their fertility. We propose that Piwi mutant sterility is a reproductive arrest phenotype that is characterized by perturbed germ granule structure and is phenocopied by germ granule dysfunction, independent of genomic instability.

Fluid landscapes, sovereign nature: Conservation and counterinsurgency in Indian-controlled Kashmir

2017 ◽  
Vol 37 (1) ◽  
pp. 67-92 ◽  
Author(s):  
Mona Bhan ◽  
Nishita Trisal
Keyword(s):  
Nature Conservation ◽  
Water Resources ◽  
Environmental Stewardship ◽  
State Sovereignty ◽  
Political Control ◽  
Environmental Restoration ◽  
Citizen Activism

This article analyzes how environmentalism reinscribed violent forms of state sovereignty in the disputed region of Kashmir in the aftermath of a decade-long uprising against Indian rule. After the return of an elected government, six years after its suspension in 1990, environmental restoration legitimized new forms of state and nature making in Kashmir. Nature rather than territory emerged as an arena of citizen activism, which further strengthened the state's ability to regulate the use and management of Kashmir's water resources. State and civic bodies deployed discourses of history and restoration to create new and imagined ecologies based on visions of nostalgia, commerce, and esthetics. By undermining place-based understandings of nature and ecology, discourses of environmental stewardship and conservation ended up fostering violent mechanisms of social and political control.

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