Cell Cycle Regulation by TGFb Signaling in C. elegans

2000 ◽  
Author(s):  
Richard Padgett
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
C Elegans ◽  
Tgfb Signaling ◽  
Cycle Regulation

scholarly journals DREAM represses distinct targets by cooperating with different THAP domain proteins

2020 ◽  
Author(s):  
Csenge Gal ◽  
Francesco Nicola Carelli ◽  
Alex Appert ◽  
Chiara Cerrato ◽  
Ni Huang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Mechanism Of Action ◽  
Cell Cycle Regulation ◽  
Gene Body ◽  
C Elegans ◽  
Cellular Quiescence ◽  
And Function ◽  
Cycle Regulation

ABSTRACTThe DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle and other genes, but its mechanism of action is unclear. Here we demonstrate that two C. elegans THAP domain proteins, LIN-15B and LIN-36, co-localize with DREAM and function by different mechanisms for repression of distinct sets of targets. LIN-36 represses classical cell cycle targets by promoting DREAM binding and gene body enrichment of H2A.Z, and we find that DREAM subunit EFL-1/E2F is specific for LIN-36 targets. In contrast, LIN-15B represses germline specific targets in the soma by facilitating H3K9me2 promoter marking. We further find that LIN-36 and LIN-15B differently regulate DREAM binding. In humans, THAP proteins have been implicated in cell cycle regulation by poorly understood mechanisms. We propose that THAP domain proteins are key mediators of Rb/DREAM function.

scholarly journals Cell‐cycle regulation of NOTCH signaling during C. elegans vulval development

2012 ◽  
Vol 8 (1) ◽  
pp. 618 ◽  
Author(s):  
Stefanie Nusser‐Stein ◽  
Antje Beyer ◽  
Ivo Rimann ◽  
Magdalene Adamczyk ◽  
Nir Piterman ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Notch Signaling ◽  
Cell Cycle Regulation ◽  
Vulval Development ◽  
C Elegans ◽  
Cycle Regulation

scholarly journals Developmental Control of the Cell Cycle: Insights from Caenorhabditis elegans

Genetics ◽  
2019 ◽  
Vol 211 (3) ◽  
pp. 797-829 ◽  
Author(s):  
Edward T. Kipreos ◽  
Sander van den Heuvel
Keyword(s):  
Cell Cycle ◽  
Caenorhabditis Elegans ◽  
Cell Cycle Regulation ◽  
Genetic Model ◽  
Somatic Cells ◽  
Model Systems ◽  
Cell Cycle Regulators ◽  
Animal Development ◽  
C Elegans ◽  
Cycle Regulation

During animal development, a single fertilized egg forms a complete organism with tens to trillions of cells that encompass a large variety of cell types. Cell cycle regulation is therefore at the center of development and needs to be carried out in close coordination with cell differentiation, migration, and death, as well as tissue formation, morphogenesis, and homeostasis. The timing and frequency of cell divisions are controlled by complex combinations of external and cell-intrinsic signals that vary throughout development. Insight into how such controls determine in vivo cell division patterns has come from studies in various genetic model systems. The nematode Caenorhabditis elegans has only about 1000 somatic cells and approximately twice as many germ cells in the adult hermaphrodite. Despite the relatively small number of cells, C. elegans has diverse tissues, including intestine, nerves, striated and smooth muscle, and skin. C. elegans is unique as a model organism for studies of the cell cycle because the somatic cell lineage is invariant. Somatic cells divide at set times during development to produce daughter cells that adopt reproducible developmental fates. Studies in C. elegans have allowed the identification of conserved cell cycle regulators and provided insights into how cell cycle regulation varies between tissues. In this review, we focus on the regulation of the cell cycle in the context of C. elegans development, with reference to other systems, with the goal of better understanding how cell cycle regulation is linked to animal development in general.

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