Role of Estrogen Receptor Variants in Tumorgenesis of Human Breast Cancer

1999 ◽  
Author(s):  
Etienne Leygue
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Estrogen Receptor Variants

The pathophysiological role of estrogen receptor variants in human breast cancer

1998 ◽  
Vol 65 (1-6) ◽  
pp. 175-180 ◽  
Author(s):  
Leigh C Murphy ◽  
Helmut Dotzlaw ◽  
Etienne Leygue ◽  
Amanda Coutts ◽  
Peter Watson
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Pathophysiological Role ◽  
Estrogen Receptor Variants

scholarly journals The Role of Neutrophil Estrogen Receptor Status on Maspin Synthesis via Nitric Oxide Production in Human Breast Cancer

2012 ◽  
Vol 15 (2) ◽  
pp. 181 ◽  
Author(s):  
Karabi Ganguly Bhattacharjee ◽  
Mau Bhattacharyya ◽  
Umesh Chandra Halder ◽  
Pradipta Jana ◽  
Asru K. Sinha
Keyword(s):  
Breast Cancer ◽  
Nitric Oxide ◽  
Estrogen Receptor ◽  
Human Breast Cancer ◽  
Estrogen Receptor Status ◽  
Nitric Oxide Production ◽  
Human Breast ◽  
Receptor Status ◽  
Oxide Production

scholarly journals Novel Stromal Biomarkers in Human Breast Cancer Tissues Provide Evidence for the More Malignant Phenotype of Estrogen Receptor-Negative Tumors

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Zahraa I. Khamis ◽  
Ziad J. Sahab ◽  
Stephen W. Byers ◽  
Qing-Xiang Amy Sang
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Human Breast Cancer ◽  
Genetic Alterations ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Human Breast Carcinomas ◽  
Er Positive ◽  
Cancer Tissues

Research efforts were focused on genetic alterations in epithelial cancer cells. Epithelial-stromal interactions play a crucial role in cancer initiation, progression, invasion, angiogenesis, and metastasis; however, the active role of stroma in human breast tumorigenesis in relation to estrogen receptor (ER) status of epithelial cells has not been explored. Using proteomics and biochemical approaches, we identified two stromal proteins in ER-positive and ER-negative human breast cancer tissues that may affect malignant transformation in breast cancer. Two putative biomarkers, T-cell receptor alpha (TCR-α) and zinc finger and BRCA1-interacting protein with a KRAB domain (ZBRK1), were detected in leukocytes of ER-positive and endothelial cells of ER-negative tissues, respectively. Our data suggest an immunosuppressive role of leukocytes in invasive breast tumors, propose a multifunctional nature of ZBRK1 in estrogen receptor regulation and angiogenesis, and demonstrate the aggressiveness of ER-negative human breast carcinomas. This research project may identify new stromal drug targets for the treatment of breast cancer patients.

Influence of estrogen receptor variants on the determination of ER status in human breast cancer

1999 ◽  
Vol 58 (3) ◽  
pp. 217-223 ◽  
Author(s):  
Aihua Huang ◽  
Etienne Leygue ◽  
Helmut Dotzlaw ◽  
Leigh C. Murphy ◽  
Peter H. Watson
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Estrogen Receptor Variants ◽  
Er Status
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