Early Detection of NF1 Brain Tumor Growth and Treatment Response by MRI, MRS and PET in a Trial of Novel Antitumor Drugs

1997 ◽  
Author(s):  
Peter C. Phillips
Keyword(s):  
Brain Tumor ◽  
Early Detection ◽  
Tumor Growth ◽  
Treatment Response ◽  
Antitumor Drugs

Roles of nitric oxide and polyamines in brain tumor growth

2021 ◽  
Vol 66 (1) ◽  
pp. 199-205
Author(s):  
Monika Szeliga ◽  
Jan Albrecht
Keyword(s):  
Nitric Oxide ◽  
Brain Tumor ◽  
Tumor Growth

scholarly journals A Minimalistic in Vitro 3D Model to Study F98 Rat Brain Tumor Growth

2016 ◽  
Vol 110 (3) ◽  
pp. 339a
Author(s):  
Emilie Gontran ◽  
Marjorie Juchaux ◽  
Christophe Deroulers ◽  
Mathilde Badoual ◽  
Olivier Seksek
Keyword(s):  
Brain Tumor ◽  
Tumor Growth ◽  
Rat Brain ◽  
3D Model ◽  
Rat Brain Tumor

BIOM-10. PRECLINICAL PLATFORM FOR THE IDENTIFICATION OF DEUTERIUM MAGNETIC RESONANCE SPECTROSCOPY-BASED BIOMARKERS OF BRAIN TUMOR METABOLISM

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi12-vi12
Author(s):  
Georgios Batsios ◽  
Meryssa Tran ◽  
Céline Taglang ◽  
Anne Marie Gillespie ◽  
Sabrina Ronen ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Tumors ◽  
Treatment Response ◽  
Lactate Production ◽  
Cell Suspensions ◽  
Response To Therapy ◽  
Resonance Spectroscopy

Abstract Metabolic reprogramming is a fundamental hallmark of cancer, which can be exploited for non-invasive tumor imaging. Deuterium magnetic resonance spectroscopy (2H-MRS) recently emerged as a novel, translational method of interrogating flux from 2H-labeled substrates to metabolic products. However, to date, preclinical studies have been performed in vivo, an endeavor which suffers from low-throughput and potential wastage of animal life, especially when considering studies of treatment response. Developing in vitro assays for monitoring metabolism of 2H-labeled substrates will enhance throughput, lead to the rapid evaluation of new 2H-based probes and enable identification of treatment response biomarkers, thereby allowing the best 2H-based probes to be translated for further in vivo assessment. The goal of this study was to develop a preclinical cell-based platform for quantifying metabolism of 2H-labeled probes in brain tumor models. Since the Warburg effect, which is characterized by elevated glycolytic production of lactate, is a metabolic phenotype of cancer, including brain tumors, we examined metabolism of 2H-glucose or 2H-pyruvate in patient-derived glioblastoma (GBM6) and oligodendroglioma (BT88) cells and compared to normal human astrocytes (NHACONTROL). Following incubation in media containing [6,6’-2H]glucose or [U-2H]pyruvate, 2H-MR spectra obtained from live cell suspensions showed elevated 2H-lactate production in GBM6 and BT88 cells relative to NHACONTROL. Importantly, 2H-lactate production from [6,6’-2H]glucose or from [U-2H]pyruvate was reduced in GBM6 or BT88 cells subjected to irradiation and temozolomide, which is standard of care for glioma patients, pointing to the utility of this method for detecting response to therapy. Collectively, we have, for the first time, demonstrated the ability to quantify metabolism of 2H-MRS probes in live cell suspensions and validated the utility of our assay for differentiating tumor from normal cells and assessing response to therapy. Our studies will expedite the identification of novel 2H-MRS probes for imaging brain tumors and potentially other types of cancer.

scholarly journals Bayesian Personalization of Brain Tumor Growth Model

2015 ◽  
pp. 424-432 ◽  
Author(s):  
Matthieu Lê ◽  
Hervé Delingette ◽  
Jayashree Kalpathy-Cramer ◽  
Elizabeth R. Gerstner ◽  
Tracy Batchelor ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Growth ◽  
Growth Model ◽  
Tumor Growth Model

scholarly journals Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth

2018 ◽  
pp. 1801076 ◽  
Author(s):  
Tarun Saxena ◽  
Johnathan G. Lyon ◽  
S. Balakrishna Pai ◽  
Daniel Pare ◽  
Jessica Amero ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Growth

scholarly journals Role of Macrophages in Brain Tumor Growth and Progression

2018 ◽  
Vol 19 (4) ◽  
pp. 1005 ◽  
Author(s):  
Elia Guadagno ◽  
Ivan Presta ◽  
Domenico Maisano ◽  
Annalidia Donato ◽  
Caterina Pirrone ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Growth

Brain tumor growth and response to chemotherapy in the subrenal capsule assay

1983 ◽  
Vol 106 (3) ◽  
pp. 229-233 ◽  
Author(s):  
Michael Weizs�cker ◽  
Akihito Nagamune ◽  
Karl Rathmer ◽  
Wolfgang Wechsler
Keyword(s):  
Brain Tumor ◽  
Tumor Growth ◽  
Subrenal Capsule Assay ◽  
Response To Chemotherapy ◽  
Subrenal Capsule
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