Mass-Screening of Curarimimetic Neurotoxin Antagonists

1990 ◽  
Author(s):  
Jakob Schmidt
Keyword(s):  
1999 ◽  
Vol 41 (3) ◽  
pp. 281-284 ◽  
Author(s):  
HIROAKI Ono ◽  
HIDEO Mawatari ◽  
NOBUYUKI Mizoguchi ◽  
TAKAATSU Eguchi ◽  
Nobuo Sakura1 and Mochiyuki Hamakawa
Keyword(s):  

1968 ◽  
Vol 7 (02) ◽  
pp. 111-117 ◽  
Author(s):  
M. Kashgahian

The proper use of prevalence and incidence data can result in an effective way to study the history of the disease process. Methodology is given whereby the progression, duration and transition of diseases can be elucidated. Prevalence and incidence have been redefined and used in an unconventional way in view of new types of data which are being generated by mass screening projects for disease which are able to discover presymptomatic and preclinical disease states.


1992 ◽  
Vol 42 (3) ◽  
pp. 261-272
Author(s):  
TSUNEHIRO ISHIDA ◽  
TAKAO YOKOE ◽  
YUICHI IINO ◽  
TETSUO OGAWA ◽  
TOSHIKAZU ISHIKITA ◽  
...  
Keyword(s):  

2020 ◽  
Vol 23 (19) ◽  
Author(s):  
Nishantadeb Ghatak ◽  
Sheikh Mohd Saleem ◽  
Roy Rillera Marzo ◽  
Sudip Bhattacharya ◽  
Amarjeet Singh

2019 ◽  
Vol 65 (2) ◽  
pp. 234-237
Author(s):  
Vyacheslav Cherenkov ◽  
A. Petrov ◽  
I. Gulkov ◽  
A. Kostyukov

Diagnosis of malignant tumors is an urgent problem of the modern world. Early diagnosis depends on General practitioners. The doctor should conduct a systematic examination of the patient regularly, taking into account the risk groups, gender and age. With mass screening, signs of dysplasia or an early focus, developing cancer can «slip away» [1]. Optimization of analysis and examination algorithms is required, which is not always possible for one person. Positive application of the digital program with elements of imaging in Oncology, we were able to create such a class of tasks for the preliminary subjective-objective survey of patients in three versions: with a widescreen screen and consoles for patients (group version up to 15 or more patients), interactive (touch) and tablet. The results of the survey are sent through the accepted channels to the doctor with recommendations for further examination, and the patient is given a coupon. The pilot program showed that the system of such robotic technologies in the future can replace the oncologist in its development to artificial intelligence at the stage of the primary link.


2020 ◽  
Author(s):  
Isao Yokota ◽  
Peter Y. Shane ◽  
Kazufumi Okada ◽  
Yokota Unoki ◽  
Yichi Yang ◽  
...  

Author(s):  
Manasi Gosavi ◽  
Ramesh Chavan ◽  
M. B. Bellad

Abstract Introduction β-Thalassemias are inherited hemoglobinopathies commonly encountered in practice. With chances of a promising cure being rare, the prevention of births with this disorder should assume priority, especially in low-resource countries. This can be achieved by the implementation of a mass screening program that is reliable and, at the same time, cost-effective. Objectives This study focuses on the utility of Naked Eye Single Tube Red Cell Osmotic Fragility Test (NESTROFT) as a mass screening tool to detect thalassemia carriers. Hematological parameters that may predict carrier status were also evaluated. Materials and Methods Hemoglobin estimation was performed on all consented pregnant women. If the patient was found to have hemoglobin < 11 g/dL, the blood sample was subjected to other routine hematological tests along with peripheral smear examination. NESTROFT was performed using 0.36% saline solution. Confirmation was done using high-performance liquid chromatography (HPLC). Statistical Analysis Data obtained were tabulated using version 21 of the Statistical Package for Social Sciences. Means, standard deviations, and percentages were used to describe the sample. Chi-square test and Students’ “t” test were used to identify differences between the groups. Results Of 441 pregnant women enrolled, 206 were found to be anemic. Nineteen (9.2%) of the anemic pregnant women were detected to be carriers of hemoglobinopathies. Among the hematological parameters, mean red blood cell count and reticulocyte count were higher, while mean corpuscular hemoglobin concentration was lower in carriers. Also, carriers were more likely to present with microcytic hypochromic anemia. NESTROFT showed a sensitivity of 84.21%, specificity of 96.25%, a positive predictive value of 69.56%, and a negative predictive value of 98.36%. A false-positive result was seen in 3.74% of the tests, while a false negative result was seen in 15.78% of the tests. Conclusions NESTROFT (0.36%) can be used as a simple and cost-effective mass screening tool for the detection of carrier status. This should be followed by confirmation using HPLC or hemoglobin electrophoresis.


Sign in / Sign up

Export Citation Format

Share Document