The Regenerative Response of Endogenous Neural Stem/Progenitor Cells to Traumatic Brain Injury

2014 ◽  
Author(s):  
Genevieve M. Sullivan
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Progenitor Cells ◽  
Regenerative Response ◽  
Neural Stem Progenitor Cells

scholarly journals Endogenous GFAP-Positive Neural Stem/Progenitor Cells in the Postnatal Mouse Cortex Are Activated following Traumatic Brain Injury

2012 ◽  
Vol 29 (5) ◽  
pp. 828-842 ◽  
Author(s):  
Aminul I. Ahmed ◽  
Anan B. Shtaya ◽  
Malik J. Zaben ◽  
Emma V. Owens ◽  
Clemens Kiecker ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Progenitor Cells ◽  
Mouse Cortex ◽  
Neural Stem Progenitor Cells

Human Neural Stem/Progenitor Cells Derived From Epileptic Human Brain in a Self-Assembling Peptide Nanoscaffold Improve Traumatic Brain Injury in Rats

2018 ◽  
Vol 55 (12) ◽  
pp. 9122-9138 ◽  
Author(s):  
Ali Jahanbazi Jahan-Abad ◽  
Sajad Sahab Negah ◽  
Hassan Hosseini Ravandi ◽  
Sedigheh Ghasemi ◽  
Maryam Borhani-Haghighi ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Human Brain ◽  
Progenitor Cells ◽  
Self Assembling ◽  
Neural Stem Progenitor Cells

scholarly journals Endogenous Neural Stem/Progenitor Cells Stabilize the Cortical Microenvironment after Traumatic Brain Injury

2015 ◽  
Vol 32 (11) ◽  
pp. 753-764 ◽  
Author(s):  
Kirsty J. Dixon ◽  
Michelle H. Theus ◽  
Claudiu M. Nelersa ◽  
Jose Mier ◽  
Lissette G. Travieso ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Progenitor Cells ◽  
Neural Stem Progenitor Cells

Neural stem/progenitor cells differentiate into oligodendrocytes, reduce inflammation, and ameliorate learning deficits after transplantation in a mouse model of traumatic brain injury

Glia ◽  
2015 ◽  
Vol 64 (5) ◽  
pp. 763-779 ◽  
Author(s):  
Paraskevi N. Koutsoudaki ◽  
Florentia Papastefanaki ◽  
Antonios Stamatakis ◽  
Georgia Kouroupi ◽  
Evangelia Xingi ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mouse Model ◽  
Progenitor Cells ◽  
Learning Deficits ◽  
Neural Stem Progenitor Cells

scholarly journals Modulation of gap junction-associated Cx43 in neural stem/progenitor cells following traumatic brain injury

2017 ◽  
Vol 134 ◽  
pp. 38-46 ◽  
Author(s):  
Kisha Greer ◽  
Jiang Chen ◽  
Thomas Brickler ◽  
Robert Gourdie ◽  
Michelle H. Theus
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Gap Junction ◽  
Progenitor Cells ◽  
Neural Stem Progenitor Cells

Proliferation, migration, and differentiation of human neural stem/progenitor cells after transplantation into a rat model of traumatic brain injury

2004 ◽  
Vol 100 (1) ◽  
pp. 88-96 ◽  
Author(s):  
André Wennersten ◽  
Xia Meijer ◽  
Staffan Holmin ◽  
Lars Wahlberg ◽  
Tiit Mathiesen
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Corpus Callosum ◽  
Progenitor Cells ◽  
Adult Brain ◽  
Adult Rats ◽  
Double Labeling ◽  
Content Type ◽  
Neural Stem Progenitor Cells ◽  
Fine Print

Object. Cultures containing human neural stem and progenitor cells (neurospheres) have the capacity to proliferate and differentiate into the major phenotypes of the adult brain. These properties make them candidates for therapeutic transplantation in cases of neurological diseases that involve cell loss. In this study, long-term cultured and cryopreserved cells were transplanted into the traumatically injured rat brain to evaluate the potential for human neural stem/progenitor cells to survive and differentiate following traumatic injury. Methods. Neural stem/progenitor cell cultures were established from 10-week-old human forebrain. Immunosuppressed adult rats received a unilateral parietal cortical contusion injury, which was delivered using the weight-drop method. Immediately following the injury, these animals received transplants of neural stem/progenitor cells, which were placed close to the site of injury. Two or 6 weeks after the procedure, these animals were killed and their brains were examined by immunohistochemical analysis. At both 2 and 6 weeks postoperatively, the transplanted human cells were found in the perilesional zone, hippocampus, corpus callosum, and ipsilateral subependymal zone of the rats. Compared with the 2-week time point, an increased number of HuN-positive cells was observed at 6 weeks. In addition, at 6 weeks post—injury/transplantation, the cells were noted to cross the midline to the contralateral corpus callosum and into the contralateral cortex. Double labeling demonstrated neuronal and astrocytic, but not oligodendrocytic differentiation. Moreover, the cortex appeared to provide an environment that was less hospitable to neuronal differentiation than the hippocampus. Conclusions. This study shows that expandable human neural stem/progenitor cells survive transplantation, and migrate, differentiate, and proliferate in the injured brain. These cells could potentially be developed for transplantation therapy in cases of traumatic brain injury.

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