Stress, Predictability, and Oral Fentanyl Self-Administration in Female and Male Rats

1995 ◽  
Author(s):  
Laura C. Klein
Keyword(s):  
Male Rats ◽  
Self Administration

scholarly journals Sex Differences in Escalated Methamphetamine Self-Administration and Altered Gene Expression Associated With Incubation of Methamphetamine Seeking

2019 ◽  
Vol 22 (11) ◽  
pp. 710-723 ◽  
Author(s):  
Atul P Daiwile ◽  
Subramaniam Jayanthi ◽  
Bruce Ladenheim ◽  
Michael T McCoy ◽  
Christie Brannock ◽  
...  
Keyword(s):  
Sex Differences ◽  
Nucleus Accumbens ◽  
Fixed Ratio ◽  
Female Rats ◽  
Male Rats ◽  
Mrna Levels ◽  
Self Administration ◽  
Male And Female ◽  
Orexin Receptors ◽  
Male And Female Rats

Abstract Background Methamphetamine (METH) use disorder is prevalent worldwide. There are reports of sex differences in quantities of drug used and relapses to drug use among individuals with METH use disorder. However, the molecular neurobiology of these potential sex differences remains unknown. Methods We trained rats to self-administer METH (0. 1 mg/kg/infusion, i.v.) on an fixed-ratio-1 schedule for 20 days using two 3-hour daily METH sessions separated by 30-minute breaks. At the end of self-administration training, rats underwent tests of cue-induced METH seeking on withdrawal days 3 and 30. Twenty-four hours later, nucleus accumbens was dissected and then used to measure neuropeptide mRNA levels. Results Behavioral results show that male rats increased the number of METH infusions earlier during self-administration training and took more METH than females. Both male and female rats could be further divided into 2 phenotypes labeled high and low takers based on the degree of escalation that they exhibited during the course of the METH self-administration experiment. Both males and females exhibited incubation of METH seeking after 30 days of forced withdrawal. Females had higher basal mRNA levels of dynorphin and hypocretin/orexin receptors than males, whereas males expressed higher vasopressin mRNA levels than females under saline and METH conditions. Unexpectedly, only males showed increased expression of nucleus accumbens dynorphin after METH self-administration. Moreover, there were significant correlations between nucleus accumbens Hcrtr1, Hcrtr2, Crhr2, and Avpr1b mRNA levels and cue-induced METH seeking only in female rats. Conclusion Our results identify some behavioral and molecular differences between male and female rats that had self-administered METH. Sexual dimorphism in responses to METH exposure should be considered when developing potential therapeutic agents against METH use disorder.

scholarly journals Fostering itself increases nicotine self-administration in young adult male rats

2013 ◽  
Vol 229 (2) ◽  
pp. 227-234 ◽  
Author(s):  
Emily E. Roguski ◽  
Hao Chen ◽  
Burt M. Sharp ◽  
Shannon G. Matta
Keyword(s):  
Young Adult ◽  
Adult Male ◽  
Male Rats ◽  
Self Administration ◽  
Young Adult Male

Treadmill exercise reduces self-administration of morphine in male rats

2009 ◽  
Vol 16 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Mahmoud Hosseini ◽  
Hojjat Allah Alaei ◽  
Asieh Naderi ◽  
Mohammad Reza Sharifi ◽  
Reza Zahed
Keyword(s):  
Treadmill Exercise ◽  
Male Rats ◽  
Self Administration

Role of neuropeptide neuromedin U in the nucleus accumbens shell in cocaine self-administration in male rats

2021 ◽  
Author(s):  
James M. Kasper ◽  
Ashley E. Smith ◽  
Sierra N. Miller ◽  
Ara ◽  
William K. Russell ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Male Rats ◽  
Nucleus Accumbens Shell ◽  
Self Administration

A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats

2015 ◽  
Vol 291 ◽  
pp. 108-111 ◽  
Author(s):  
Christopher D. Schmoutz ◽  
Glenn F. Guerin ◽  
Scott P. Runyon ◽  
Suraj Dhungana ◽  
Nicholas E. Goeders
Keyword(s):  
Male Rats ◽  
Self Administration ◽  
Brain Levels

scholarly journals Effects of environmental enrichment on self-administration of the short-acting opioid remifentanil in male rats

2017 ◽  
Vol 234 (23-24) ◽  
pp. 3499-3506 ◽  
Author(s):  
Rebecca S. Hofford ◽  
Jonathan J. Chow ◽  
Joshua S. Beckmann ◽  
Michael T. Bardo
Keyword(s):  
Environmental Enrichment ◽  
Male Rats ◽  
Self Administration ◽  
Short Acting

Chronic cadmium exposure alters cocaine self-administration in adult male rats.

1996 ◽  
Vol 4 (3) ◽  
pp. 264-270 ◽  
Author(s):  
Jack R. Nation ◽  
Christina L. Livermore ◽  
Gerald R. Bratton ◽  
Susan Schenk
Keyword(s):  
Adult Male ◽  
Cadmium Exposure ◽  
Male Rats ◽  
Self Administration
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