THE EFFECT OF NOSE TRUNCATION ON THE AERODYNAMIC PROPERTIES OF 9-CALIBER LONG ARMY-NAVY SPINNER ROCKET MODELS NEAR SONIC VELOCITY

1955 ◽  
Author(s):  
E. J. ROSCHKE
Keyword(s):  
Sonic Velocity ◽  
Aerodynamic Properties

THEORETICAL COMPARISON OF THE AERODYNAMIC PROPERTIES OF BRANCH SHREDDER HAMMERS WITH HORIZONTAL ROTATION AXIS

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
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Keyword(s):  
Rotation Axis ◽  
Theoretical Comparison ◽  
Aerodynamic Properties

scholarly journals Cylindrical Microparticles Composed of Mesoporous Silica Nanoparticles for the Targeted Delivery of a Small Molecule and a Macromolecular Drug to the Lungs: Exemplified with Curcumin and siRNA

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 844
Author(s):  
Thorben Fischer ◽  
Inga Winter ◽  
Robert Drumm ◽  
Marc Schneider
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Alveolar Epithelial Cells ◽  
In Vitro Toxicity ◽  
Layer By Layer ◽  
Necrosis Factor Alpha ◽  
Aerodynamic Properties ◽  
Tnf Α

The transport of macromolecular drugs such as oligonucleotides into the lungs has become increasingly relevant in recent years due to their high potency. However, the chemical structure of this group of drugs poses a hurdle to their delivery, caused by the negative charge, membrane impermeability and instability. For example, siRNA to reduce tumour necrosis factor alpha (TNF-α) secretion to reduce inflammatory signals has been successfully delivered by inhalation. In order to increase the effect of the treatment, a co-transport of another anti-inflammatory ingredient was applied. Combining curcumin-loaded mesoporous silica nanoparticles in nanostructured cylindrical microparticles stabilized by the layer-by-layer technique using polyanionic siRNA against TNF-α was used for demonstration. This system showed aerodynamic properties suited for lung deposition (mass median aerodynamic diameter of 2.85 ± 0.44 µm). Furthermore, these inhalable carriers showed no acute in vitro toxicity tested in both alveolar epithelial cells and macrophages up to 48 h incubation. Ultimately, TNF-α release was significantly reduced by the particles, showing an improved activity co-delivering both drugs using such a drug-delivery system for specific inhibition of TNF-α in the lungs.

scholarly journals Analysis and Design of a Leading Edge with Morphing Capabilities for the Wing of a Regional Aircraft—Gapless Chord- and Camber-Increase for High-Lift Performance

2021 ◽  
Vol 11 (6) ◽  
pp. 2752
Author(s):  
Conchin Contell Asins ◽  
Volker Landersheim ◽  
Dominik Laveuve ◽  
Seiji Adachi ◽  
Michael May ◽  
...  
Keyword(s):  
Leading Edge ◽  
Bird Strike ◽  
High Lift ◽  
Analysis And Design ◽  
Actuation System ◽  
Aerodynamic Properties ◽  
Reinforced Plastic ◽  
Stall Angle ◽  
Carbon Fibre Reinforced Plastic ◽  
Electromechanical Actuation

In order to contribute to achieving noise and emission reduction goals, Fraunhofer and Airbus deal with the development of a morphing leading edge (MLE) as a high lift device for aircraft. Within the European research program “Clean Sky 2”, a morphing leading edge with gapless chord- and camber-increase for high-lift performance was developed. The MLE is able to morph into two different aerofoils—one for cruise and one for take-off/landing, the latter increasing lift and stall angle over the former. The shape flexibility is realised by a carbon fibre reinforced plastic (CFRP) skin optimised for bending and a sliding contact at the bottom. The material is selected in terms of type, thickness, and lay-up including ply-wise fibre orientation based on numerical simulation and material tests. The MLE is driven by an internal electromechanical actuation system. Load introduction into the skin is realised by span-wise stringers, which require specific stiffness and thermal expansion properties for this task. To avoid the penetration of a bird into the front spar of the wing in case of bird strike, a bird strike protection structure is proposed and analysed. In this paper, the designed MLE including aerodynamic properties, composite skin structure, actuation system, and bird strike behaviour is described and analysed.

scholarly journals Beyond analogy: A model of bioinspiration for creative design

2016 ◽  
Vol 30 (2) ◽  
pp. 159-170 ◽  
Author(s):  
Camila Freitas Salgueiredo ◽  
Armand Hatchuel
Keyword(s):  
Design Process ◽  
Design Theory ◽  
Leading Edge ◽  
Knowledge Bases ◽  
Biologically Inspired ◽  
Concept Knowledge ◽  
Bioinspired Design ◽  
Aerodynamic Properties ◽  
Biologically Inspired Design ◽  
The Impact

AbstractIs biologically inspired design only an analogical transfer from biology to engineering? Actually, nature does not always bring “hands-on” solutions that can be analogically applied in classic engineering. Then, what are the different operations that are involved in the bioinspiration process and what are the conditions allowing this process to produce a bioinspired design? In this paper, we model the whole design process in which bioinspiration is only one element. To build this model, we use a general design theory, concept–knowledge theory, because it allows one to capture analogy as well as all other knowledge changes that lead to the design of a bioinspired solution. We ground this model on well-described examples of biologically inspired designs available in the scientific literature. These examples include Flectofin®, a hingeless flapping mechanism conceived for façade shading, and WhalePower technology, the introduction of bumps on the leading edge of airfoils to improve aerodynamic properties. Our modeling disentangles the analogical aspects of the biologically inspired design process, and highlights the expansions occurring in both knowledge bases, scientific (nonbiological) and biological, as well as the impact of these expansions in the generation of new concepts (concept partitioning). This model also shows that bioinspired design requires a special form of collaboration between engineers and biologists. Contrasting with the classic one-way transfer between biology and engineering that is assumed in the literature, the concept–knowledge framework shows that these collaborations must be “mutually inspirational” because both biological and engineering knowledge expansions are needed to reach a novel solution.

scholarly journals Measurements of aerodynamic properties of badminton shuttlecocks

2010 ◽  
Vol 2 (2) ◽  
pp. 2487-2492 ◽  
Author(s):  
Firoz Alam ◽  
Harun Chowdhury ◽  
Chavaporn Theppadungporn ◽  
Aleksandar Subic
Keyword(s):  
Aerodynamic Properties

Inhalable Spray Dried Pro-Liposome Powder Containing Budesonide for Pulmonary Delivery

2021 ◽  
Vol 14 (4) ◽  
pp. 5538-5548
Author(s):  
Aliasgar J Kundawala ◽  
Khushbu S Chauhan ◽  
Harsha V Patel ◽  
Swati K Kurtkoti
Keyword(s):  
Drug Release ◽  
Spray Drying ◽  
Entrapment Efficiency ◽  
Geometric Standard Deviation ◽  
Drying Method ◽  
Dry Powder ◽  
Liposomal Drug ◽  
Vesicle Size ◽  
Aerodynamic Properties ◽  
Spray Dried

Budesonide is an anti-asthmatic agent which is used to control the symptoms of asthma like bronchospasm, oedema. Drug delivered to lung through inhalation will provide systemic and local drug delivery at lower dose in chronic and acute diseases. Dry powder inhalers are the best choice for targeting the anti-asthmatic drugs through pulmonary route. The objective of the present study is to prepare inhalable lipid coated budesonide microparticles by spray drying method so effective delivery of budesonide to the lungs can be achieved. The microparticles in the form of dry powder were obtained by either spray drying liposomal drug suspension or lipid drug suspension. The liposomes were initially prepared by solvent evaporation method using Hydrogenated Soyabean Phosphatidylcholine and Cholesterol (1:1, 1:2, 2:1) as lipid carrier and then spray dried later with mannitol as bulking agent at different lipid to diluent ratio (1:1.25, 1:2.5 & 1:5). The liposomes and liposomal dry powder were evaluated for vesicle size, % entrapment efficiency, in vitro drug release studies, powder characteristics, aerosol performance and stability studies. The liposomes prepared showed vesicle size (2-8 µm), Entrapment efficiency (92.22%) at lipid: drug ratio of (2.5:1) and observed 80.41 % drug release in 24 hrs. Pro-liposomes prepared by spray drying of liposomal drug suspension (LSD1) showed emitted dose, mean mass aerodynamic diameter, geometric standard deviation and fine particle fraction of 99.01%, 3.12 µm, 1.78 and 43.5% along with good powder properties. The spray dried powder was found to be stable at 4 ± 2 °C & 65% ± 5 % RH. The inhalable microparticles containing Budesonide containing lipid dry powder was successfully prepared by spray drying method that showed good aerodynamic properties and stability with mannitol as diluent. The microparticles produced with this novel approach could deliver drug on target via inhalation route and also ease manufacture process at large scale in fewer production steps.

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