scholarly journals Effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray regional state, Ethiopia: a prospective cohort study

2019 ◽  
Author(s):  
Abadi Kidanemariam Berhe ◽  
Abiodun O. ILESANMI ◽  
Christopher O. AIMAKHU ◽  
Afework Mulugeta
Keyword(s):  
Perinatal Outcome ◽  
Neonatal Intensive Care ◽  
Perinatal Death ◽  
Birth Asphyxia ◽  
Perinatal Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Adverse Perinatal Outcome ◽  
Regional State ◽  
Induced Hypertension ◽  
Adverse Perinatal Outcomes

Abstract Background: The prevalence of pregnancy-induced hypertension in Ethiopia ranges from 2.2 to 18.3%. However, so far little is known about the adverse perinatal outcomes of pregnancy-induced hypertension in Tigray regional state, Ethiopia. Therefore, the objective of this study was to assess the effect of pregnancy-induced hypertension on adverse perinatal outcomes in Tigray Regional State, Ethiopia. Methods: a prospective cohort study was conducted on a total sample of 782 pregnant women attending antenatal care in hospitals of Tigray regional state, Ethiopia. Pregnant mothers diagnosed with PIH during the data collection period in the selected hospitals were included as exposed group and normotensive women were also enrolled as a control group. Data were collected using an interviewer-administered questionnaire and review of their medical records from February 2018, to February 2019. The adverse perinatal outcome event includes low birth weight, birth asphyxia, small for gestational age, preterm delivery, admission to neonatal intensive care unit and perinatal death. A modified Poisson regression model with robust standard errors was used to analyze relative risk. Results: In this study, the overall incidence of adverse perinatal outcome was higher among women with pregnancy-induced hypertension than normotensive women (66.4% vs 22.2%). After adjusted for confounders women with pregnancy-induced hypertension were born babies with a higher risk of low birth weight (adjusted RR(95%CI)= 5.1(3.4,7.8)), birth asphyxia (aRR=2.6(1.9,3.8)), small for gestational age (aRR=3.3(2.3,4.6)), preterm delivery (aRR=5.2(3.4,7.9)), stillbirth (aRR=3.46(1.40,8.54)), admission to neonatal intensive care unit (aRR=5.1(3.1,8.4)) and perinatal death (aRR=3.6(1.8,7.4)) compared to normotensive pregnant women. Conclusions: Higher incidences of adverse perinatal outcomes occurred among women pregnancy-induced hypertension in Tigray regional state, Ethiopia. Hence health care providers should strengthen prevention, early diagnosis and prompt management of pregnancy-induced hypertension to reduce adverse perinatal outcomes of pregnancy-induced hypertension. Keywords: Adverse perinatal outcomes, pregnancy-induced hypertension, Tigray, Ethiopia

scholarly journals Effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray regional state, Ethiopia: a prospective cohort study

2019 ◽  
Author(s):  
Abadi Kidanemariam Berhe ◽  
Abiodun O. ILESANMI ◽  
Christopher O. AIMAKHU ◽  
Afework Mulugeta
Keyword(s):  
Perinatal Outcome ◽  
Neonatal Intensive Care ◽  
Perinatal Death ◽  
Birth Asphyxia ◽  
Perinatal Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Adverse Perinatal Outcome ◽  
Regional State ◽  
Induced Hypertension ◽  
Adverse Perinatal Outcomes

Abstract Background: The prevalence of pregnancy-induced hypertension in Ethiopia ranges from 2.2 to 18.3%. However, so far little is known about the adverse perinatal outcomes of pregnancy-induced hypertension in Tigray regional state, Ethiopia. Therefore, the objective of this study was to assess the effect of pregnancy-induced hypertension on adverse perinatal outcomes in Tigray Regional State, Ethiopia. Methods: a prospective cohort study was conducted on a total sample of 782 pregnant women attending antenatal care in hospitals of Tigray regional state, Ethiopia. Pregnant mothers diagnosed with PIH during the data collection period in the selected hospitals were included as exposed group and normotensive women were also enrolled as a control group. Women diagnosed with pregnancy-induced hypertension between 28 and 35 weeks of gestation were enrolled for follow up to this study. Data were collected using an interviewer-administered questionnaire and review of their medical records from February 2018, to February 2019. The adverse perinatal outcome event includes low birth weight, birth asphyxia, small for gestational age, preterm delivery, admission to neonatal intensive care unit and perinatal death. A modified Poisson regression model with robust standard errors was used to analyze relative risk. Results: In this study, the overall incidence of adverse perinatal outcome was higher among women with pregnancy-induced hypertension than normotensive women (66.4% vs 22.2%). After adjusted for confounders women with pregnancy-induced hypertension were born babies with a higher risk of low birth weight (adjusted RR(95%CI)= 5.1(3.4,7.8)), birth asphyxia (aRR=2.6(1.9,3.8)), small for gestational age (aRR=3.3(2.3,4.6)), preterm delivery (aRR=5.2(3.4,7.9)), stillbirth (aRR=3.46(1.40,8.54)), admission to neonatal intensive care unit (aRR=5.1(3.1,8.4)) and perinatal death (aRR=3.6(1.8,7.4)) compared to normotensive pregnant women. Conclusions: Higher incidences of adverse perinatal outcomes occurred among women pregnancy-induced hypertension in Tigray regional state, Ethiopia. Hence health care providers should strengthen prevention, early diagnosis and prompt management of pregnancy-induced hypertension to reduce adverse perinatal outcomes of pregnancy-induced hypertension. Keywords : Adverse perinatal outcomes, pregnancy-induced hypertension, Tigray, Ethiopia

scholarly journals Effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray regional state, Ethiopia: a prospective cohort study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Abadi Kidanemariam Berhe ◽  
Abiodun O. Ilesanmi ◽  
Christopher O. Aimakhu ◽  
Afework Mulugeta
Keyword(s):  
Perinatal Outcome ◽  
Neonatal Intensive Care ◽  
Perinatal Death ◽  
Birth Asphyxia ◽  
Perinatal Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Adverse Perinatal Outcome ◽  
Regional State ◽  
Induced Hypertension ◽  
Adverse Perinatal Outcomes

Abstract Background The prevalence of pregnancy-induced hypertension in Ethiopia ranges from 2.2 to 18.3%. However, so far little is known about the adverse perinatal outcomes of pregnancy-induced hypertension in Tigray regional state, Ethiopia. Therefore, the objective of this study was to assess the effect of pregnancy-induced hypertension on adverse perinatal outcomes in Tigray Regional State, Ethiopia. Methods a prospective cohort study was conducted on a total sample of 782 pregnant women attending antenatal care in hospitals of Tigray regional state, Ethiopia. Pregnant mothers diagnosed with PIH during the data collection period in the selected hospitals were included as exposed group and normotensive women were also enrolled as a control group. This study addresses women diagnosed with preeclampsia, eclampsia and gestational hypertension between 28 and 35 weeks of gestation. Data were collected using an interviewer-administered questionnaire and review of their medical records from February 2018, to February 2019. The adverse perinatal outcome event includes low birth weight, birth asphyxia, small for gestational age, preterm delivery, admission to neonatal intensive care unit and perinatal death. A modified Poisson regression model with robust standard errors was used to analyze relative risk. Results In this study, the overall incidence of adverse perinatal outcome was higher among women with pregnancy-induced hypertension than normotensive women (66.4% vs 22.2%). After adjusted for confounders women with pregnancy-induced hypertension were born babies with a higher risk of low birth weight (adjusted RR (95%CI) = 5.1(3.4,7.8)), birth asphyxia (aRR = 2.6(1.9,3.8)), small for gestational age (aRR = 3.3(2.3,4.6)), preterm delivery (aRR = 5.2(3.4,7.9)), stillbirth (aRR = 3.46(1.40,8.54)), admission to neonatal intensive care unit (aRR = 5.1(3.1,8.4)) and perinatal death (aRR = 3.6(1.8,7.4)) compared to normotensive pregnant women. Conclusions Higher incidences of adverse perinatal outcomes occurred among women pregnancy-induced hypertension in Tigray regional state, Ethiopia. Hence, health care providers should strengthen prevention, early diagnosis and prompt management of pregnancy-induced hypertension to reduce adverse perinatal outcomes of pregnancy-induced hypertension.

scholarly journals Effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray regional state, Ethiopia: a prospective cohort study

2019 ◽  
Author(s):  
Abadi Kidanemariam Berhe ◽  
Abiodun O. ILESANMI ◽  
Christopher O. AIMAKHU ◽  
Afework Mulugeta
Keyword(s):  
Perinatal Outcome ◽  
Neonatal Intensive Care ◽  
Perinatal Death ◽  
Birth Asphyxia ◽  
Perinatal Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Adverse Perinatal Outcome ◽  
Regional State ◽  
Induced Hypertension ◽  
Adverse Perinatal Outcomes

Abstract Background: The prevalence of pregnancy-induced hypertension in Ethiopia ranges from 2.2 to 18.3%. However, so far little is known about the adverse perinatal outcomes of pregnancy-induced hypertension in Tigray regional state, Ethiopia. Therefore, the objective of this study was to assess the effect of pregnancy-induced hypertension on adverse perinatal outcomes in Tigray Regional State, Ethiopia. Methods: a prospective cohort study was conducted on a total sample of 782 pregnant women attending antenatal care in hospitals of Tigray regional state, Ethiopia. Pregnant mothers diagnosed with PIH during the data collection period in the selected hospitals were included as exposed group and normotensive women were also enrolled as a control group. This study addresses women diagnosed with preeclampsia, eclampsia and gestational hypertension between 28 and 35 weeks of gestation. Data were collected using an interviewer-administered questionnaire and review of their medical records from February 2018, to February 2019. The adverse perinatal outcome event includes low birth weight, birth asphyxia, small for gestational age, preterm delivery, admission to neonatal intensive care unit and perinatal death. A modified Poisson regression model with robust standard errors was used to analyze relative risk. Results: In this study, the overall incidence of adverse perinatal outcome was higher among women with pregnancy-induced hypertension than normotensive women (66.4% vs 22.2%). After adjusted for confounders women with pregnancy-induced hypertension were born babies with a higher risk of low birth weight (adjusted RR(95%CI)= 5.1(3.4,7.8)), birth asphyxia (aRR=2.6(1.9,3.8)), small for gestational age (aRR=3.3(2.3,4.6)), preterm delivery (aRR=5.2(3.4,7.9)), stillbirth (aRR=3.46(1.40,8.54)), admission to neonatal intensive care unit (aRR=5.1(3.1,8.4)) and perinatal death (aRR=3.6(1.8,7.4)) compared to normotensive pregnant women. Conclusions: Higher incidences of adverse perinatal outcomes occurred among women pregnancy-induced hypertension in Tigray regional state, Ethiopia. Hence, health care providers should strengthen prevention, early diagnosis and prompt management of pregnancy-induced hypertension to reduce adverse perinatal outcomes of pregnancy-induced hypertension. Keywords: Adverse perinatal outcomes, pregnancy-induced hypertension, Tigray, Ethiopia

scholarly journals Effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray regional state, Ethiopia: a prospective cohort study

2019 ◽  
Author(s):  
Abadi Kidanemariam Berhe ◽  
Abiodun O. ILESANMI ◽  
Christopher O. AIMAKHU ◽  
Afework Mulugeta
Keyword(s):  
Cohort Study ◽  
Pregnant Women ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Perinatal Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Care Providers ◽  
Regional State ◽  
Induced Hypertension ◽  
Adverse Perinatal Outcomes

Abstract Background: Pregnancy-induced hypertension is the development of new hypertension with or without proteinuria after 20 weeks of pregnancy. The prevalence of pregnancy-induced hypertension in Ethiopia ranges from 2.2 to 18.3%. Similarly, a study conducted in Tigray regional state indicated a higher prevalence of pregnancy-induced hypertension. However, so far little is known about the adverse perinatal outcomes of pregnancy-induced hypertension in Tigray Regional State, Ethiopia. Therefore the objective of this study was to assess the effect of pregnancy-induced hypertension on adverse perinatal outcomes in Tigray Regional State, Ethiopia. Methods: a prospective cohort study was conducted on a total sample of 782 pregnant women attending antenatal care in hospitals of Tigray regional state, Ethiopia. Data were collected using interviewer-administered questionnaire and review of their medical records from February 1, 2018, to February 30, 2019. Maternal age, wealth status, educational status, residence, gravidity, type of pregnancy, mode of delivery, anemia status and maternal undernutrition variables were controlled in the statistical models. A modified Poisson regression model with robust standard errors was used to analyze Relative risk. Results: In this study, the overall incidence of adverse perinatal outcome was higher among women with pregnancy-induced hypertension than normotensive women (66.4% vs 22.2%). After adjusted for confounders women with pregnancy-induced hypertension were born babies with a higher risk of low birth weight (adjusted RR(95%CI)= 5.1(3.4,7.8)), birth asphyxia (aRR=2.6(1.9,3.8)), small for gestational age (aRR=3.3(2.3,4.6)), preterm delivery (aRR=5.2(3.4,7.9)), stillbirth (aRR=3.46(1.40,8.54)), admission to neonatal intensive care unit (aRR=5.1(3.1,8.4)) and perinatal death (aRR=3.6(1.8,7.4)) compared to normotensive pregnant women. Conclusions: Higher incidences of adverse perinatal outcomes were occurred among women pregnancy-induced hypertension in Tigray regional state, Ethiopia. Hence health care providers should strengthen prevention, early diagnosis and prompt management of pregnancy-induced hypertension to reduce adverse perinatal outcomes of pregnancy-induced hypertension. Keywords: Adverse perinatal outcomes, pregnancy-induced hypertension, Tigray, Ethiopia

Amniotic-Umbilical-to-Cerebral Ratio – A Novel Ratio Combining Doppler Parameters and Amniotic Fluid Volume to Predict Adverse Perinatal Outcome in SGA Fetuses At Term

2020 ◽  
Author(s):  
Florian Matthias Stumpfe ◽  
Florian Faschingbauer ◽  
Sven Kehl ◽  
Jutta Pretscher ◽  
Julius Emons ◽  
...  
Keyword(s):  
Perinatal Outcome ◽  
Neonatal Intensive Care ◽  
Predictive Accuracy ◽  
Area Under The Curve ◽  
Perinatal Outcomes ◽  
Fetal Distress ◽  
Adverse Perinatal Outcome ◽  
Adverse Perinatal Outcomes ◽  
Nicu Admission ◽  
Singleton Pregnancies

Abstract Purpose Introduction of a novel ratio – the amniotic-umbilical-to-cerebral ratio (AUCR) – to predict adverse perinatal outcome in SGA fetuses at term and comparison of its predictive accuracy with established parameters. Materials and Methods This retrospective cohort study included 165 singleton pregnancies with SGA fetuses (birth weight < 10th percentile) at term. Cases with planned vaginal delivery and documented pulsatility indices (PI) of the umbilical artery (UA), middle cerebral artery (MCA), and single deepest pocket (SDP) were included. CPR was calculated as the ratio between MCA PI and UA PI, UCR as the ratio between UA PI and MCA PI. AUCR was defined as follows: SDP/(UA PI/MCA PI). Adverse perinatal outcomes were defined as operative intervention (OI), OI due to fetal distress, admission to the neonatal intensive care unit (NICU), and composite adverse perinatal outcome (CAPO). Associations between Doppler parameters and these outcomes were estimated using regression analyses. Results OI was statistically significantly associated with UCR, SDP, and AUCR, whereas no association was observed for UA PI, MCA PI, and CPR. Fetuses requiring OI due to fetal distress revealed a significantly higher UA PI and UCR as well as a lower MCA PI, CPR, and AUCR. With regard to NICU admission and CAPO, a significantly higher UA PI and lower CPR were found. Furthermore, a significant association was shown for SDP, UCR, and AUCR. AUCR achieved the best area under the curve for all outcome parameters. Conclusion AUCR leads to an improvement in the prediction of unfavorable outcome in SGA fetuses at term. Furthermore, results of our study show that UCR might be superior to CPR.

scholarly journals Effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray Regional State, Ethiopia: a prospective cohort study

2019 ◽  
Author(s):  
Abadi Kidanemariam Berhe ◽  
Abiodun O. ILESANMI ◽  
Christopher O. AIMAKHU ◽  
Afework Mulugeta
Keyword(s):  
Cohort Study ◽  
Pregnant Women ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Perinatal Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Care Providers ◽  
Regional State ◽  
Induced Hypertension ◽  
Adverse Perinatal Outcomes

Abstract Background: Pregnancy induced hypertension is the development of new hypertension with or without proteinuria after 20 weeks of pregnancy. The prevalence of pregnancy induced hypertension in Ethiopia ranges from 2.2 to 18.3%. However, little is known about the adverse perinatal outcomes of pregnancy induced hypertension in Tigray Regional State, Ethiopia.Therefore the objective of this study was to assess effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray Regional State, Ethiopia. Methods: a prospective cohort study was conducted on a total sample of 782 pregnant women attending antenatal care in hospitals of Tigray regional state, Ethiopia. Data were collected using interviewer-administered questionnaire and review of their medical records from February 1, 2018, to February 30, 2019. Data analysis was performed using Stata version 14.0. Relative risk with 95% CI for the association between pregnancy induced hypertension and perinatal outcomes were assessed using Poisson regression analysis. Results: In this study the overall incidence of adverse perinatal outcome was higher among women with pregnancy induced hypertension than normotensive women ( 66.4% vs 22.2%). After adjusted for confounders women with pregnancy induced hypertension were born babies with a higher risk of low birth weight (adjusted RR(95%CI)= 5.1(3.4,7.8)), birth asphyxia (aRR=2.6(1.9,3.8)), small for gestational age (aRR=3.3(2.3,4.6)), preterm delivery (aRR=5.2(3.4,7.9)), admission to neonatal intensive care unit (aRR=5.1(3.1,8.4)) and with a higher risk of perinatal death (aRR=3.6(1.8,7.4)) compared to normotensive pregnant women Conclusions: Higher incidences of adverse perinatal outcomes were occurred among women pregnancy induced hypertension in Tigray regional state, Ethiopia. Hence health care providers should strengthen prevention, early diagnosis and prompt management of pregnancy induced hypertension to reduce adverse perinatal outcomes of pregnancy induced hypertension. Keywords : Adverse perinatal outcomes, pregnancy induced hypertension, Tigray, Ethiopia

scholarly journals Significance of obstetric Doppler studies in prediction of perinatal outcome in pregnancy induced hypertension

2017 ◽  
Vol 6 (6) ◽  
pp. 2354 ◽  
Author(s):  
Pradip R. Gaikwad ◽  
Manisha R. Gandhewar ◽  
Nity Rose ◽  
Vidyadhar Suryakar
Keyword(s):  
Diagnostic Accuracy ◽  
Doppler Ultrasound ◽  
Predictive Value ◽  
Perinatal Outcome ◽  
Uterine Artery ◽  
Pregnancy Induced Hypertension ◽  
Doppler Studies ◽  
Uterine Artery Doppler ◽  
Adverse Perinatal Outcome ◽  
Induced Hypertension

Background: Pregnancy induced hypertension (PIH) is associated with adverse perinatal outcome. Multi vessel color Doppler studies are useful in these cases for timely intervention. The aim of present study was to know the significance of umbilical, middle cerebral and uterine artery Doppler studies in PIH and to analyse its role in predicting perinatal outcome.Methods: This was a prospective study of 106 singleton pregnancies in the third trimester with PIH. The results of last Doppler ultrasound within one week of delivery were used for analysis. Adverse perinatal outcome was studied in the form of emergency cesarean section for fetal distress, meconium stained amniotic fluid, Apgar at 5 min <7, NICU admission and perinatal mortality (stillbirths and neonatal death). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of various Doppler parameters were calculated after comparing with standard.Results: In the present study specificity and diagnostic accuracy of all Doppler ultrasound parameters was high in predicting adverse perinatal outcome. Cerebroplacental ratio showed highest specificity (98.55%), PPV (94.44%) and diagnostic accuracy (80.19%) in predicting adverse perinatal outcome and it is better than MCA PI and UA PI alone. Uterine artery Doppler evaluation also gives additional information in predicting adverse perinatal outcome.Conclusions: Amongst various Doppler parameters cerebroplacental index (MCA/UA PI) is best predictor of adverse perinatal outcome.

scholarly journals Study of risk factors and perinatal outcome in meconium stained deliveries from a district of Uttar Pradesh, India

2018 ◽  
Vol 7 (9) ◽  
pp. 3605
Author(s):  
Richa Rathoria ◽  
Ekansh Rathoria ◽  
Utkarsh Bansal ◽  
Madhulika Mishra ◽  
Ila Jalote ◽  
...  
Keyword(s):  
Risk Factors ◽  
Amniotic Fluid ◽  
Perinatal Outcome ◽  
Birth Asphyxia ◽  
Meconium Aspiration Syndrome ◽  
Pregnancy Induced Hypertension ◽  
Meconium Aspiration ◽  
Fetal Bradycardia ◽  
Induced Hypertension ◽  
Meconium Stained Amniotic Fluid

Background: The objective is to identify the risk factors of Meconium stained deliveries and evaluate the perinatal outcomes in Meconium Stained deliveries.Methods: This prospective observational study included those pregnant women who had completed 37 weeks of gestation, with singleton pregnancies with cephalic presentations and with no known fetal congenital anomalies. Among these, we selected 110 cases with Meconium stained amniotic fluid and they were compared with 110 randomly selected controls.Results: Regular antenatal visits were seen in 22.73 % of the cases while 77.27% cases had no previous visit. Majority of cases were primigravida and gestational ages of >40 weeks was seen in 55.45 % cases. 19.09% cases had meconium staining among pregnancies complicated with pregnancy induced hypertension, as compared to those among controls (5.45%). Fetal heart rate abnormalities were seen in 29.09% cases, and statistically significant fetal bradycardia was seen in cases. Caesarean section rates were nearly double in cases (54.55%). Poor perinatal outcome was found in cases as seen in results by low Apgar score (<7) at 1 minute and 5-minute, higher incidence of birth asphyxia, Meconium Aspiration Syndrome and increased NICU admission as compared to that among controls.Conclusions: Meconium stained amniotic fluid is more commonly associated with higher gestational age >40 weeks, pregnancy induced hypertension and fetal bradycardia, increased cesarean section rates, low APGAR score and higher incidence of birth asphyxia and NICU admissions. Meconium aspiration syndrome was associated with early neonatal death.

scholarly journals Exploring  the influence of advanced maternal age on adverse perinatal outcome in Southern Anhui province, China

2019 ◽  
Author(s):  
Dandan Ge ◽  
Mingshu Si ◽  
Yong Xia
Keyword(s):  
Risk Factors ◽  
Perinatal Outcome ◽  
Maternal Age ◽  
Multiple Logistic Regression Analysis ◽  
Multiple Pregnancy ◽  
Perinatal Outcomes ◽  
Advanced Maternal Age ◽  
Multiple Logistic Regression ◽  
Adverse Perinatal Outcome ◽  
Adverse Perinatal Outcomes

Abstract Background : Elderly parturient women may face many pregnancy risks, which have serious consequences for perinatal and maternal. The objective of this study is to explore the association between advanced maternal age and adverse perinatal outcomes. Methods : In this study, we used retrospective study to randomly selected 977 puerpera ( aged 35 years and older) as the research group and 977 puerpera (aged 20 to 34 years older) as the control group from Yijishan Hospital for the years 2017-2018. Univariate analysis was used to test the association between gestational age and adverse perinatal outcomes. Multiple logistic regression analysis was performed to examine the factors associated with adverse perinatal outcome. A nomogram was conducted to explore the risk probability between risk factors and adverse perinatal outcome. Results : the AMA group (23.2%)exhibited a higher incidence of adverse perinatal outcome than the Non-AMA group(17.8%). Multiple logistic regression analysis showed among those who experienced multiple pregnancy, premature, hypertension, diabetes were more likely to induce adverse perinatal outcome. In this study, the risk of adverse perinatal outcome occurred in women aged 35 to 45 years with multiple pregnancy and preterm birth all was 42%-48%. The risk of adverse perinatal outcome in women aged 35 to 45 years with other variables respectively were 18%-19% (diabetes), 16%-18% (hypertension).The risk of adverse perinatal outcomes among women with AMA combined with these variables were higher than the counterpart. Conclusions : AMA is the risk factor for adverse perinatal outcome among pregnancy women and the probability that these risk factors combined with age produced poor perinatal outcome were also found. Active intervention measures focusing on the complications and treatment in AMA should be taken to ensure the health of mother and baby.

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