Novel Deployment of Tracers Leads to High-Confidence Results

2021 ◽  
Author(s):  
Claudio R Ramos
Keyword(s):  
Production Performance ◽  
Control Group ◽  
Petroleum Reservoir ◽  
Course Of Action ◽  
New Findings ◽  
The Right ◽  
Stimulation Efficiency ◽  
Surfactant Effects ◽  
The Impact ◽  
Well Completions

Abstract A unique well-tracing design for three horizontally drilled wells is presented utilizing proppant tracers and water- and hydrocarbon-soluble tracers to evaluate multiple completion strategies. Results are combined to present an interpretation of them in the reservoir as a whole, where applicable, as well as on an individual well basis. The new approach consists of tracing the horizontal well(s) leaving unchanged segments along the wellbore to obtain relevant control group results not available otherwise. The application of the tracers throughout each wellbore was designed to mitigate or counterbalance variables out of the controllable completion engineering parameters such as heterogeneity along the wellbores, existing reservoir depletion, intra- and inter-well hydraulically driven interactions (frac hits) as well as to minimize any unloading and production biases. Completion strategies are provided, and all the evaluation methodologies are described in detail to permit readers to replicate the approach. One field case study with five horizontal wells is presented. Three infill wells were drilled between two primary wells of varying ages. All wells are shale oil wells with approximately 7,700 ft lateral sections. The recovery of each tracer is compared between the surfactant treated and untreated segments on each well and totalized to see how the petroleum reservoir system is performing. A complete project economic analysis was performed to determine the viability of a chemical additive (a production enhancement surfactant). Meticulous analysis and interpretation of the proppant image logs were performed to discern the cluster stimulation efficiency during the hydraulic fracturing treatments. Furthermore, comparisons of the cluster stimulation efficiency between the two mesh sizes of proppant pumped are also provided for each of the three new unconventional well completions. The most significant new findings are the surfactant effects on the wells’ production performance, and the impact the engineered perforations with tapered shots along the stages had on the stimulation efficiency. Both the right chemistry for the formation and higher cluster stimulation efficiencies are important because they can lead to increased well oil production. The novelty of this tracing design methodology rests in the ability to generate results with a statistically relevant sample size, therefore, increasing the confidence in the conclusions and course of action in future well completions.

S275 – Nasal Morphology and Nasal Patency in Leprosy Patients

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P167-P167
Author(s):  
Maria Teresa Torres Larrosa ◽  
Luis Jorge Peréz Peréz ◽  
Juan-Jose Artazkoz-del Toro
Keyword(s):  
Drug Therapy ◽  
Therapy Group ◽  
Control Group ◽  
Nasal Patency ◽  
Multidrug Therapy ◽  
Airway Patency ◽  
Expiratory Resistance ◽  
Leprosy Patients ◽  
The Right ◽  
The Impact

Objectives 1) To assess the impact of multi-drug leprosy therapy on the development of nasal deformities and nasal airway patency. 2) Evaluate the nasal morphology and nasal patency in leprosy patients treated with the multidrug therapy in comparison with patients treated with 1 drug therapy and a group of healthy volunteers. Methods In an overall group of 84 patients studied, 38 were treated with a therapy based on a single drug, and 22 were treated with multi-drug therapy, while 24 subjects formed a control group. We used anterior rhinoscopy to analised the morphology of the nose. We meassured the nasal inspiratory and expiratory resistance of the right and left nostrils and total nasal inspiratory and expiratory resistance at a transnasal pressure of 150 Pa. by using active anterior rhinomanometry. The statistical analysis was carried out using the Varianza analisys. Results The nasal structures in the 1-drug therapy group underwent bone and cartilaginous resorption with an increase in nasal resistances. We found significant statistical differences between the resistance values obtained in this group and the control group (p<0,05). In the multidrug therapy group, the morphology of the nose remains as in healthy patients. No significant statistical differences were found between the resistance values obtained in the multidrug therapy patients and the control group (P>0,05). Conclusions The multidrug therapy prevents developing nasal deformities and maintains a normal nasal airflow.

scholarly journals Increased Amygdala Activity Associated With Cognitive Reappraisal Strategy in Functional Neurologic Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Thomas Hassa ◽  
Stefan Spiteri ◽  
Roger Schmidt ◽  
Christian Merkel ◽  
Mircea Ariel Schoenfeld
Keyword(s):  
Cognitive Reappraisal ◽  
Control Group ◽  
Neurologic Disorder ◽  
Affective Stimuli ◽  
Negative Images ◽  
Amygdala Activity ◽  
Emotion Regulation Strategy ◽  
Valence And Arousal ◽  
The Right ◽  
The Impact

Cognitive reappraisal is an emotion regulation strategy to reduce the impact of affective stimuli. This regulation could be incomplete in patients with functional neurologic disorder (FND) resulting in an overflowing emotional stimulation perpetuating symptoms in FND patients. Here we employed functional MRI to study cognitive reappraisal in FND. A total of 24 FND patients and 24 healthy controls employed cognitive reappraisal while seeing emotional visual stimuli in the scanner. The Symptom Checklist-90-R (SCL-90-R) was used to evaluate concomitant psychopathologies of the patients. During cognitive reappraisal of negative IAPS images FND patients show an increased activation of the right amygdala compared to normal controls. We found no evidence of downregulation in the amygdala during reappraisal neither in the patients nor in the control group. The valence and arousal ratings of the IAPS images were similar across groups. However, a subgroup of patients showed a significant higher account of extreme low ratings for arousal for negative images. These low ratings correlated inversely with the item “anxiety” of the SCL-90-R. The increased activation of the amygdala during cognitive reappraisal suggests altered processing of emotional stimuli in this region in FND patients.

scholarly journals The Effects of Ankle Sprain on Balance Tests in Adolescent Volleyball Players with Previous History of Ankle Sprain

2014 ◽  
Vol 2 (11_suppl3) ◽  
pp. 2325967114S0018
Author(s):  
Ceyda Sarıal ◽  
Abdulhamıt Tayfur ◽  
Beyza Kap ◽  
Dılara Donder ◽  
Ozum Melıs Ertuzun ◽  
...  
Keyword(s):  
Ankle Sprain ◽  
Previous History ◽  
Control Group ◽  
Balance Test ◽  
Balance Tests ◽  
Volleyball Players ◽  
History Of ◽  
One Year ◽  
The Right ◽  
The Impact

Objectives: To investigate the impact of having previous history of inversion ankle sprain on balance tests in adolescent volleyball players. Methods: Fourty-five adolescent volleyball players with mean age of 15.26±1.03 participated in our study. Twenty-nine were uninjured (control group) and sixteen had previously experienced inversion injuries on right ankle. 9 players had the injury more than than one year ago and 7 players had it before six to twelf months. Balancing abilities were evaluated by Star Excursion Balance Test (SEBT) and Single Limb Hurdle Test (SLHT). The fact that players with history of injury had the ankle sprain at right foot led us to perform the measurements in the control group also for the right foot. We compared the results of injured and uninjured players on both tests. Results: Uninjured players' reaching distance on right foot was found out to be significantly more than in players with ankle sprain at medial and posteromedial directions of SEBT(p<.05), whereas there were no differences detected for the other directions (p>.05). For comparing athletes' performances with SLHT, finishing time was found significantly better in uninjured players (p<.05). Conclusion: Adolescent volleyball players with history of injury show lower performance on balance tests compared to uninjured players. This demonstrates that they should be given a training including balance and stabilization programs.

The influence of intellectual disability on longitudinal arching and symmetry of lateral and medial load of the foot

2019 ◽  
Vol 6 (1) ◽  
pp. 29-34
Author(s):  
Marta Bibro ◽  
Agnieszka Jankowicz-Szymańska ◽  
Katarzyna Wódka ◽  
Małgorzata Łaczek-Wójtowicz
Keyword(s):  
Intellectual Disability ◽  
Intellectual Disabilities ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Control Group ◽  
Functional Efficiency ◽  
Flat Feet ◽  
People With Intellectual Disabilities ◽  
The Right ◽  
The Impact

Background: In the population of people with intellectual disabilities (ID) there is a frequent occurrence of bone deformities and orthopedic problems affecting the feet as well. They are associated with a change of the loading of the feet. It affects the deterioration of the functional efficiency of the feet, often contributes to discomfort, pain and predisposes to the development of adverse changes in the upper body segments. The aim of the study was to assess the impact of intellectual disability in participants with aetiology other than Down’s syndrome on longitudinal arching and symmetry of lateral and medial load of the foot. Materials and methods: There were 38 participants with mild and moderate intellectual disability, with an average age of 23 years and 44 young non-disabled people with an average age of 20.8 under research. The main measurement tool used to assess the arching and loading the foot zones was the BTS P-WALK platform. The measurement included analysis in terms of statics and lasted 30s. Results: The comparison of both groups showed no significant differentiation in the medial and lateral load of the forefoot and rearfoot. Among people with ID correct arches of the feet were observed in 52.6% of participants in the right foot and 57.9% of the left foot, while in the control group in 56.9% in both the right and left foot. People with intellectual disabilities were characterized by a higher rate of flatfoot in relation to the control group. The hollow foot was more frequently observed in control group than in people with ID. Conclusions: In people with intellectual disabilities with aetiology other than Down’s syndrome, flat feet are diagnosed more often than in healthy peers who do not differ in body weight and BMI. Intellectual disability is associated with a greater loading of the medial part of the forefoot.

The German Integration Panel: how to measure the influence of integration courses on migrants integration?

2014 ◽  
Vol 7 (1) ◽  
pp. 43-55
Author(s):  
Nina Rother
Keyword(s):  
Language Proficiency ◽  
Large Scale ◽  
Language Skills ◽  
German Society ◽  
German Language ◽  
Control Group ◽  
Key Issues ◽  
Large Scale Survey ◽  
The Right ◽  
The Impact

In 2005, Germany’s Federal Government introduced integration courses in order to enable migrants to improve their German language skills and thereby also their general integration into German society. From 2005 to 2007, about 500,000 migrants were granted the right to take part in an integration course. Several methodological challenges had to be overcome when establishing the German Integration Panel, a longitudinal survey aimed at analysing the efficiency and sustainability of integration courses and the impact they have on general integration processes. Among the key issues of this large-scale survey was its global design, especially the composition and accessibility of a control group of non-course participants as well as the assessment of German language proficiency. 

scholarly journals Implication of an Objectivist-Constructivist Blended Approach on Students’ Achievement and Satisfaction in University-Level Beginner String Technique Classes

2018 ◽  
Vol 2 (3) ◽  
pp. 173
Author(s):  
Shafizan Bin Sabri
Keyword(s):  
Teaching And Learning ◽  
Instructional Material ◽  
Control Group ◽  
Quasi Experimental ◽  
Equivalent Control ◽  
University Level ◽  
Teaching Music ◽  
Efficient Learning ◽  
The Right ◽  
The Impact

<p><em>Teaching music generally implicates multidimensional process whereby an assortment of approaches should be incorporated in order to provide the right and proper ambience for teaching and learning process. The need to explore and further understand the complexity in teaching beginner string technique class instigates the study which explore the implication of an objectivist-constructivist blended approach for teaching beginners string technique class. This paper explores the impact of blended-approach teaching on students’ achievement and satisfaction in Malaysian university-level beginner string technique classes. Using a quasi-experimental non-equivalent control group post-test only design, students (N = 40) from two local public universities were assigned to one of two treatment condition: experimental group, where students were presented with blended approach instructional material, and control group, where students were presented with conventional instructional material. Students completed the course of 14 weeks. The implementation results revealed that the proposed blended approach contributes to meaningful and efficient learning.</em></p>

scholarly journals Evaluation of Subclinical Hypothyroidism on Auditory Divided Attention

2019 ◽  
Author(s):  
Fatemeh Khorasani ◽  
Nematollah Rouhbakhsh ◽  
Ahmad Geshani ◽  
Mohammad Reza Mohajeri Tehrani ◽  
Mostafa Qorbani
Keyword(s):  
Divided Attention ◽  
Subclinical Hypothyroidism ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Cross Sectional ◽  
Endocrine Disorder ◽  
Significant Difference ◽  
Healthy Control ◽  
The Right ◽  
The Impact

Introduction: Subclinical hypothyroidism is an endocrine disorder that can adversely affect cognitive performance. In this regard, patients with subclinical hypothyroidism may develop poor attention. However, the effects of this endocrine disorder on auditory attention is unclear. This study aims to evaluate the impact of subclinical hypothyroidism on auditory divided attention. Materials and Methods: This cross-sectional, case control study was  performed  on 30 adult patients, aged 20-40 years, who met the study inclusion criteria. Based on their Thyroid Stimulating Hormone (TSH) level, the subjects were divided into two case groups  (each  with 15 patients) with a TSH level of 5˂TSH≤10 and 10˂TSH≤15. A healthy control group was recruited with matched age, sex, and education with the case groups. The participants were evaluated by the Persian version of the Bergen dichotic listening test. Among different experimental situations that included non-forced attention, forced right, and forced left, we chose the non-forced attention. Statistical analysis was done in SPSS V. 25. Results: There was a significant difference between the subclinical hypothyroid (5˂TSH≤10 group) and controls in the scores of the right and left ear. However, there was no significant difference between scores of right and left ear in subclinical hypothyroid (10˂TSH≤15 group). No significant difference in scores of the right and left ear was found between men and women in three groups. Conclusion: Subclinical hypothyroidism had no effect on auditory divided attention.

scholarly journals The influence of cervical spine rehabilitation on bioelectrical activity (sEMG) of cervical and masticatory system muscles

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250746
Author(s):  
Renata Kielnar ◽  
Anna Mika ◽  
Dorota Bylina ◽  
Jarosław Sołtan ◽  
Artur Stolarczyk ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Neck Pain ◽  
Temporomandibular Joint ◽  
Rehabilitation Programme ◽  
Control Group ◽  
Bioelectrical Activity ◽  
Upper Trapezius ◽  
The Right ◽  
The Impact ◽  
Experimental Group

Background Coexistence of temporomandibular joint discomfort along with cervical spine disorders is quite common, and is associated with many limitations and adverse symptoms for the patient. Both diagnostics and treatment of these ailments are difficult, and in many cases, the effects of therapy are not satisfactory. This study assessed the impact of a 3-week neck-only rehabilitation programme without direct intervention in the craniofacial area on the bioelectric activity of both the cervical spine and muscles in the craniofacial area among patients with idiopathic neck pain who do not report TMJ pain. Design A parallel group trial with follow-up; Setting: Rehabilitation Clinic. Methods Twenty five patients experiencing idiopathic neck pain underwent the 3-week rehabilitation programme. Thirty five age-matched subjects with no cervical spine and temporomandibular joint (TMJ) dysfunctions were control group. At baseline and after 3 weeks the cervical and craniofacial area muscles’ bioelectrical activity (sEMG) was evaluated. Results In the experimental group during cervical flexion, a significant decrease of sEMG amplitude was noted in the right (mean 25.1 μV; 95% CI: 21.5–28.6 vs mean 16.8 μV; 95% CI: 13.8–19.7) and left (mean 25.9 μV; 95% CI: 21.7–30.0 vs mean 17.2 μV; 95% CI: 13.6–20.7) Sternocleidomastoid as well as a significant increase in sEMG amplitude of the right (mean 11.1 μV; 95% CI: 7.9–14.2 vs mean 15.7 μV; 95% CI: 12.1–19.2) and left (mean 15.3 μV; 95% CI: 11.9–18.6 vs mean 20.2 μV; 95% CI: 15.7–24.2) Upper Trapezius muscles. In the experimental group, after therapy right and left Sternocleidomastoid, Temporalis Anterior and Masseter muscles presented lower fatigue levels. Conclusions Three weeks of rehabilitation without any therapeutic intervention in temporomandibular joint significantly decreased the bioelectrical activity of the neck and craniofacial muscles while improving the muscle pattern of coactivation in participants with idiopathic neck pain who do not report temporomandibular joint pain. These observations could be helpful in the physiotherapeutic treatment of neck and craniofacial area dysfunctions. Trial registration ID ISRCTN14511735—retrospectively registered.

Differential time course of action of 5-HT3 and NK1 antagonists when used with highly and moderately emetogenic chemotherapy (HEC and MEC)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 9629-9629
Author(s):  
P. J. Hesketh ◽  
D. G. Warr ◽  
J. C. Street ◽  
A. D. Carides
Keyword(s):  
Active Control ◽  
Time Course ◽  
Phase Iii ◽  
Control Group ◽  
Active Control Group ◽  
Logistic Regression Models ◽  
Course Of Action ◽  
Intent To Treat ◽  
Post Hoc ◽  
The Impact

9629 Background: Cisplatin-based HEC displays a biphasic pattern of emesis with both an early and delayed period. In contrast, MEC has a monophasic pattern. The objective of this analysis was to investigate the time course of action of the 5-HT3antagonist ondansetron (OND) and the NK1 antagonist aprepitant (APR) in trials with HEC and MEC. Methods: Phase III HEC and MEC trials of APR were included. In 2 HEC studies, patients (pts) scheduled to receive cisplatin- based chemotherapy were randomized to an active-control group (OND + dexamethasone [DEX] Day 1, DEX bid Days 2–4) or an APR group (APR + OND + DEX Day 1; APR + DEX qd Days 2–3; and DEX Day 4). In a third HEC study, control pts also received OND on Days 2- 3. For the MEC study, breast cancer pts receiving anthracycline + cyclophosphamide-based chemotherapy were randomized to an active- control group (OND + DEX pre chemotherapy and OND 8 hours (h) later; OND bid Days 2–3) or an APR group (APR + OND + DEX pre chemotherapy and OND 8 h later; APR qd Days 2–3). In a post-hoc analysis, multivariate logistic regression models were used to assess the impact on emesis at different time intervals using a modified intent-to-treat approach. No multiplicity adjustment was planned, so nominal p-values are reported. Results: 1,527 pts and 856 pts were randomized and assessed for efficacy in the HEC and MEC trials respectively. For HEC, APR reduced risk of emesis beginning 15–18 h after cisplatin and extending to 48 h by 45–77% compared to control and by 45–67% compared to the OND control. For MEC, APR markedly reduced emesis from 6–9 h by 61% compared to control (p=0.0012). Conclusions: Time of onset (15 h vs. 6 h) and time course (15–48 h vs. 6–9 h) for the enhanced control of emesis with the addition of APR differs between HEC and MEC respectively. With HEC these results suggest that 5-HT3 dependent mechanisms are most important in the first 12 h after HEC with NK1-dependent mechanisms having a key role later. With MEC both 5-HT3 and NK1 mechanisms appear to be important early and the greatest impact of the NK1 antagonist occurs in the first 9 h. These results provide a rationale for maximizing NK1-antagonist exposure early on with MEC as a means to improve emesis control. [Table: see text]

Effects of cediranib (VEGF signaling inhibitor) on edema in newly diagnosed glioblastoma patients during initial chemoradiation.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 2012-2012 ◽  
Author(s):  
Pavlina Polaskova ◽  
Marco C Pinho ◽  
Jayashree Kalpathy-Cramer ◽  
Alexander R Guimaraes ◽  
Patrick Y. Wen ◽  
...  
Keyword(s):  
Antiangiogenic Therapy ◽  
Control Group ◽  
Newly Diagnosed ◽  
Post Contrast ◽  
Diffusion Weighted Images ◽  
Apparent Diffusion ◽  
Adc Values ◽  
Newly Diagnosed Glioblastoma ◽  
The Right ◽  
The Impact

2012 Background: A significant benefit of antiangiogenic therapy is control of brain edema. We evaluated the impact of adding cediranib to standard chemoradiation (CRT) on peritumoral edema in patients with newly diagnosed glioblastoma(GBM) during the initial 6 weeks of CRT. Methods: Two cohorts of patients were enrolled in two clinical trials. The control group (N=13) received radiation for 6 weeks plus temozolomide. The cediranib (CED) group received standard CRT plus daily cediranib (N=34). MRIs were performed at baseline and weekly during CRT. Volumes of interest (VOIs) were drawn outlining the enhancing tumor on T1-weighted post contrast images and the abnormal FLAIR hyperintensity. ADC (apparent diffusion coefficient) maps were calculated from diffusion-weighted images and histograms of the distribution of ADC values created for each visit using the baseline FLAIR VOI to characterize the peritumoraledema. Patients were on stable or decreasing doses of steroids. Results: In the CED group, T1 and FLAIR VOI decreased during CRT vs controls where T1 VOI did not change and FLAIR VOI increased. By the end of CRT, the mode of the ADC histogram in the CED group shifted to the left while the mode of the controls shifted to the right. The skewness, a measure of asymmetry of the distribution, increased in the CED group and decreased in controls. Conclusions: In patients with newly diagnosed GBM treated with CRT and cediranib, tumor volume decreased on T1 and FLAIR images whereas the FLAIR volume significantly increased in the control group suggesting increased edema. The shift of mode to the right and decreasing skewness in controls (indicating an increase in the proportion of very high ADC values) suggests that adding cediranibprevented the development of edema and contributed to the resolution of existing edema. Preventing the edema by adding anti-VEGF treatment may improve the tolerability of CRT for GBM patients. [Table: see text]

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