Workplace Management of Carcinogens, Mutagens and Reproductive Toxicants

2019 ◽  
Author(s):  
A’edah Abu-Bakar ◽  
Masao Fukumura ◽  
Salmaan Hussain Inayat Hussain
Keyword(s):  
Reproductive Toxicants

Cellular and molecular features of endometrial hyperplasia under the influence of industrial toxic factors

2020 ◽  
pp. 690-690
Author(s):  
I. O. Marinkin ◽  
E. S. Lisova ◽  
V. V. Evchenko
Keyword(s):  
Oxidative Stress ◽  
Growth Factor ◽  
Endometrial Hyperplasia ◽  
Transforming Growth Factor ◽  
Length Of Service ◽  
Ki67 Expression ◽  
Molecular Features ◽  
Reproductive Toxicants ◽  
Cd34 Expression ◽  
And Oxidative Stress

The features of biomechanisms of endometrial hyperplasia in subjects exposed to reproductive toxicants were inflammation and oxidative stress. An association of Ki67 expression with 8-hydroxydeoxyguanosine, length of service, CD34 expression with 8-isoprostane and both Ki67 and CD34 expression with transforming growth factor B1 and lead exposure established.

Reproductive toxicants have a threshold of adversity

2011 ◽  
Vol 41 (6) ◽  
pp. 545-554 ◽  
Author(s):  
Aldert H. Piersma ◽  
Lya G. Hernandez ◽  
Jan van Benthem ◽  
J. J. Andre Muller ◽  
F.X. Rolaf van Leeuwen ◽  
...  
Keyword(s):  
Reproductive Toxicants

Proceedings of the Workshop on One-vs Two-Generation Reproductive Effects Studies

1988 ◽  
Vol 7 (7) ◽  
pp. 911-925 ◽  
Author(s):  
Elaine Z. Francis ◽  
Gary L. Kimmel
Keyword(s):  
Reproductive Toxicity ◽  
Toxicity Testing ◽  
Critical Factor ◽  
Test Methods ◽  
Toxic Substances ◽  
Test Protocol ◽  
Reproductive Effects ◽  
Toxicity Potential ◽  
Adequate Evaluation ◽  
Reproductive Toxicants

The Workshop on One-vs Two-Generation Reproductive Effects Studies was held on October 21-22, 1987. It was organized by the USEPA's Office of Pesticides and Toxic Substances and Office of Research and Development and was supported by the Agency's Risk Assessment Forum. The purpose of the workshop was to address the central question: Is a single-generation reproductive effects study sufficient to assess the reproductive toxicity potential of chemicals that do not bioaccumulate? In response to this question, the panel of nine participants concluded that, by itself, a one-generation reproductive effects study is insufficient to identify all potential reproductive toxicants and that a two-generation study is needed for an adequate assessment. The panel did not support placing much importance on bioaccumulation as related to reproductive toxicity testing mainly because it is not the only critical factor that may account for effects in a second generation but not in the first. In studying broader issues, the panel accomplished several goals that hopefully may serve to direct future development in reproductive toxicity testing: (1) the purpose of a reproductive effects study was defined, (2) a minimal set of end points necessary for adequate evaluation of reproductive toxicity was determined, (3) some alternative reproductive effects test methods were recommended, (4) greater flexibility in choosing a test protocol on a case by case basis was encouraged, and (5) areas that need further research were identified.

Framework for Identifying Chemicals with Structural Features Associated with the Potential to Act as Developmental or Reproductive Toxicants

2013 ◽  
Vol 26 (12) ◽  
pp. 1840-1861 ◽  
Author(s):  
Shengde Wu ◽  
Joan Fisher ◽  
Jorge Naciff ◽  
Michael Laufersweiler ◽  
Cathy Lester ◽  
...  
Keyword(s):  
Structural Features ◽  
Reproductive Toxicants
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