Field Testing The Polysaccharide Schizophyllan: Results of The First Year

Author(s):  
Bernd Leonhardt ◽  
Burkhard Ernst ◽  
Sabrina Reimann ◽  
Alexander Steigerwald ◽  
Florian Lehr
Keyword(s):  
Author(s):  
I. Gordon

In summer 1973, the sheep farmer in most parts of the Irish Republic could telephone his local cattle Artificial Insemination (AI) station and ask for a technician to treat his ewes for ‘early-lamb’ (December/January) production with intravaginal sponges and pregnant mare's serum gonadotrophin (PMSG). The 60 p per ewe service, which first became available at that time, covered two visits by the technician: the first to insert sponges; the second, 14 days later, to withdraw them and administer the gonadotrophin. On the basis of considerable experimental evidence, the farmer could expect about 60 to 70% of ewes treated to conceive to first services and lamb within a short period of each other, and some 80% to produce offspring to the combined first and second services. The scheme, based on natural service, was used by several hundred farmers in that first year of operation, and was made available on a similar basis again in 1974. The introduction of this cheap, effective and simple technique for the hormonal control of reproduction in sheep was the result of considerable activity over the years by Dr Sean Crowley and his staff in An Foras Taluntais and various workers in University College, Dublin (UCD). Due credit must be given, however, to the Irish Department of Agriculture, which sponsored extensive field testing of controlled breeding techniques in 197/172, and subsequently arranged with cattle AI stations to provide countrywide coverage on a fee per ewe basis from 1973.


2013 ◽  
Vol 40 (4) ◽  
pp. 281 ◽  
Author(s):  
Allen T. Rutberg ◽  
Ricky E. Naugle ◽  
John W. Turner ◽  
Mark A. Fraker ◽  
Douglas R. Flanagan

Context Many contraceptive agents have demonstrated effectiveness in wild species, most notably immunocontraceptives such as GnRH conjugates and porcine zona pellucida (PZP). The major challenge in using these agents to control deer and other wildlife populations in the field now lies with safe, effective and efficient delivery to a large-enough proportion of the population to suppress growth. Aims Because deer and other wildlife are typically difficult to access for treatment, contraceptives that require multiple or repeated treatments will be of limited management value. To address this constraint, we conducted a field study of white-tailed deer (Odocoileus virginianus) on Fripp Island, SC, USA, to test two different technologies for achieving single-administration, multi-year efficacy in PZP vaccines. Methods Between 2005 and 2010, we captured, ear-tagged and blood-sampled a total of 245 individual adult and yearling female deer. Deer were hand-injected at capture with one of two preparations of SpayVac or a combination native PZP–adjuvant emulsion plus PZP–adjuvant incorporated into lactide–glycolide polymer pellets engineered to release at 1, 3 and 12 months post-treatment. Pregnancy was determined from serum assays of pregnancy-specific protein B sampled from captured deer. Key results Aqueous SpayVac, and the PZP–adjuvant-containing polymer pellets manufactured through a heat extrusion (H/X) method administered simultaneously with PZP–AdjuVac or modified Freund’s complete adjuvant emulsions reduced pregnancy rates from control levels by 95–100% in the first year after treatment, and by 65–70% in the second year after treatment. Conclusions A single, hand-injected vaccination with SpayVac or PZP–adjuvant emulsion combined with H/X PZP pellets reduced fertility for multiple years. Implications Single-treatment, multi-year immunocontraceptive vaccines bring contraceptive management of wildlife populations one step closer. Future efforts should focus on improving handling and storage, developing technologies for remote delivery, and addressing remaining regulatory and management concerns.


1977 ◽  
Vol 41 (8) ◽  
pp. 507-510 ◽  
Author(s):  
AC Rosen ◽  
M Marcus ◽  
N Johnson

1986 ◽  
Vol 50 (5) ◽  
pp. 264-267 ◽  
Author(s):  
GH Westerman ◽  
TG Grandy ◽  
JV Lupo ◽  
RE Mitchell

2019 ◽  
Vol 62 (11) ◽  
pp. 4001-4014
Author(s):  
Melanie Weirich ◽  
Adrian Simpson

Purpose The study sets out to investigate inter- and intraspeaker variation in German infant-directed speech (IDS) and considers the potential impact that the factors gender, parental involvement, and speech material (read vs. spontaneous speech) may have. In addition, we analyze data from 3 time points prior to and after the birth of the child to examine potential changes in the features of IDS and, particularly also, of adult-directed speech (ADS). Here, the gender identity of a speaker is considered as an additional factor. Method IDS and ADS data from 34 participants (15 mothers, 19 fathers) is gathered by means of a reading and a picture description task. For IDS, 2 recordings were made when the baby was approximately 6 and 9 months old, respectively. For ADS, an additional recording was made before the baby was born. Phonetic analyses comprise mean fundamental frequency (f0), variation in f0, the 1st 2 formants measured in /i: ɛ a u:/, and the vowel space size. Moreover, social and behavioral data were gathered regarding parental involvement and gender identity. Results German IDS is characterized by an increase in mean f0, a larger variation in f0, vowel- and formant-specific differences, and a larger acoustic vowel space. No effect of gender or parental involvement was found. Also, the phonetic features of IDS were found in both spontaneous and read speech. Regarding ADS, changes in vowel space size in some of the fathers and in mean f0 in mothers were found. Conclusion Phonetic features of German IDS are robust with respect to the factors gender, parental involvement, speech material (read vs. spontaneous speech), and time. Some phonetic features of ADS changed within the child's first year depending on gender and parental involvement/gender identity. Thus, further research on IDS needs to address also potential changes in ADS.


2011 ◽  
Vol 21 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Sena Crutchley

This article describes how a telepractice pilot project was used as a vehicle to train first-year graduate clinicians in speech-language pathology. To date, six graduate clinicians have been trained in the delivery of telepractice at The University of North Carolina at Greensboro. Components of telepractice training are described and the benefits and limitations of telepractice as part of clinical practicum are discussed. In addition, aspects of training support personnel involved in telepractice are outlined.


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