Time-Delayed Fracturing: A New Strategy in Multi-Stage, Multi-Well Pad Fracturing

2013 ◽  
Author(s):  
Ripudaman Manchanda ◽  
Mukul Mani Sharma
Keyword(s):  
Multi Stage ◽  
New Strategy

scholarly journals Highly luminescent dual mode rare-earth nanorod assisted multi-stage excitable security ink for anti-counterfeiting applications

2014 ◽  
Vol 2 (48) ◽  
pp. 10468-10475 ◽  
Author(s):  
Pawan Kumar ◽  
Jaya Dwivedi ◽  
Bipin Kumar Gupta
Keyword(s):  
Rare Earth ◽  
Dual Mode ◽  
Multi Stage ◽  
New Strategy

Demonstration of new strategy for designing multi-stage excitable highly-luminescent Y2O3:Yb3+/Er3+ nanorod assisted security ink for protection against counterfeiting.

FOCUS4: A prospective molecularly stratified, adaptive multicenter program of randomized controlled trials for patients with colorectal cancer (CRC).

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. TPS3645-TPS3645
Author(s):  
Kai-Keen Shiu ◽  
Tim Maughan ◽  
Richard H. Wilson ◽  
Richard A. Adams ◽  
Cheryl Pugh ◽  
...  
Keyword(s):  
Randomised Trial ◽  
Gene Mutations ◽  
Progression Free Survival ◽  
Predictive Biomarker ◽  
Double Blind ◽  
Interim Analyses ◽  
Pten Loss ◽  
Molecular Stratification ◽  
Multi Stage ◽  
New Strategy

TPS3645 Background: Targeted therapies based on somatic gene mutations or activated pathways have inhibited progression of some cancers. However, although various targets are identifiable in CRC, KRAS mutation is currently the only validated predictive biomarker for selection of a targeted therapy. FOCUS4 is a rolling phase II-III trial for testing in a staged way both the utility of molecular stratification and the efficacy of novel agents in subpopulations of mCRC patients. It is also a trial of a new strategy for testing stratified approaches to therapy in any biologically complex tumour type using a Multi-Arm, Multi-Stage design. Methods: The study population consists of subjects with newly diagnosed inoperable mCRC. Subjects receive first-line chemotherapy for 16 weeks. During this time the tumour is tested for BRAF/PIK3CA/KRAS/NRAS mutations and PTEN loss. Subjects with responding or stable disease on CT, who would normally be candidates for a treatment break, are then randomised to four coherent biomarker-based subgroups: FOCUS4-A: BRAF mutant, FOCUS4-B: PIK3CA mutant or complete loss of PTEN on IHC, FOCUS4-C: KRAS or NRAS mutant, FOCUS4-D: All wild type (no mutations of BRAF, PIK3CA, KRAS or NRAS). For each subgroup, a relevant novel agent or combination is to be tested in an adaptive double-blind placebo controlled randomised trial design with multiple interim analyses for early termination if there is no strong evidence of worthwhile activity. There will also be a 5thsubgroup FOCUS4-N testing maintenance capecitabine for unclassifiable tumours or for patients whose marker defined cohort is temporarily suspended. The primary endpoint is progression free survival. Promising results in any biomarker defined cohort will then be tested for response in cohorts without the biomarker. Within the overall trial, biomarker developments can be accommodated with changes in the distribution of the cohorts or testing of new targeted agents. Enrolment will commence in May 2013. Upto 3400 patients will be registered over a 4-5 year period depending on which cohorts pass their staged interim analyses and proceed to later stages, including an overall survival endpoint. Clinical trial information: 2012-005111-12.

A new strategy for prenatal diagnosis in a sporadic haemophilia B family

Haemophilia ◽  
2001 ◽  
Vol 7 (4) ◽  
pp. 416-418 ◽  
Author(s):  
M. Acquila ◽  
F. Bottini ◽  
A. Valetto ◽  
D. Caprino ◽  
P. G. Mori ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Haemophilia B ◽  
New Strategy

Guidelines Bring New Strategy in Low-Risk AF

2012 ◽  
Vol 45 (15) ◽  
pp. 12-13
Author(s):  
BRUCE JANCIN
Keyword(s):  
Low Risk ◽  
New Strategy

New Strategy for the Synthesis of 2-Deoxy-C-aryl-nucleoside Frameworks

2006 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
S.M. Mahalingam ◽  
S. Vijayasaradhi ◽  
I.S. Aidhen
Keyword(s):  
New Strategy

Planning and Search in Multi-Stage Risky Decision Making

2011 ◽  
Author(s):  
Jared Hotaling ◽  
Jerry Busemeyer ◽  
Richard Shiffrin
Keyword(s):  
Decision Making ◽  
Risky Decision Making ◽  
Risky Decision ◽  
Multi Stage

New strategy to search lead compounds with unique structures from plants

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
T Villani ◽  
K Gustafson ◽  
J Zhen ◽  
JE Simon ◽  
Q Wu
Keyword(s):  
Lead Compounds ◽  
New Strategy

Latin America in Difficult Search of Its Way

2004 ◽  
pp. 107-117
Author(s):  
Z. Romanova
Keyword(s):  
Latin America ◽  
Demographic Structure ◽  
Financial Problems ◽  
Strategy Of Development ◽  
Small Countries ◽  
New Strategy

The article is devoted to the analysis of economic and financial problems and contradictions accumulated in Latin America under conditions of globalization and market liberation. The originated unfavorable changes gave rise to the need of policy correction in big and small countries. The author analyses a new strategy of development adequate for Latin America with its specific geopolitical situation, demographic structure and history.

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