Fluid Composition Equilibrium; a Proxy for Reservoir Connectivity

Author(s):  
Thomas Pfeiffer ◽  
Zulfiquar Reza ◽  
David Schechter ◽  
William D. McCain ◽  
Oliver C. Mullins
2007 ◽  
Author(s):  
David Anthony Hutchinson ◽  
Najiya Kuramshina ◽  
Ali Chingiz Oglu Sheydayev ◽  
Simon N.J. Day

2007 ◽  
Author(s):  
John W. Snedden ◽  
Peter Vrolijk ◽  
Larry Sumpter ◽  
Michael L. Sweet ◽  
Kevin R. Barnes ◽  
...  

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 272
Author(s):  
Arik Dahan ◽  
Isabel González-Álvarez

The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even within the segment, are dependent on many factors, e.g., the surrounding pH, fluid composition, transporters expression, metabolic enzymes activity, tight junction resistance, different morphology along the GIT, variable intestinal mucosal cell differentiation, changes in drug concentration (in cases of carrier-mediated transport), thickness and types of mucus, and resident microflora. Each of these variables, alone or in combination with others, can fundamentally alter the solubility/dissolution, the intestinal permeability, and the overall absorption of various drugs. This is the underlying mechanistic basis of regional-dependent intestinal drug absorption, which has led to many attempts to deliver drugs to specific regions throughout the GIT, aiming to optimize drug absorption, bioavailability, pharmacokinetics, and/or pharmacodynamics. In this Editorial we provide an overview of the Special Issue "Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation". The objective of this Special Issue is to highlight the current progress and to provide an overview of the latest developments in the field of regional-dependent intestinal drug absorption and delivery, as well as pointing out the unmet needs of the field.


2019 ◽  
Vol 38 (6) ◽  
pp. 474-479
Author(s):  
Mohamed G. El-Behiry ◽  
Said M. Dahroug ◽  
Mohamed Elattar

Seismic reservoir characterization becomes challenging when reservoir thickness goes beyond the limits of seismic resolution. Geostatistical inversion techniques are being considered to overcome the resolution limitations of conventional inversion methods and to provide an intuitive understanding of subsurface uncertainty. Geostatistical inversion was applied on a highly compartmentalized area of Sapphire gas field, offshore Nile Delta, Egypt, with the aim of understanding the distribution of thin sands and their impact on reservoir connectivity. The integration of high-resolution well data with seismic partial-angle-stack volumes into geostatistical inversion has resulted in multiple elastic property realizations at the desired resolution. The multitude of inverted elastic properties are analyzed to improve reservoir characterization and reflect the inversion nonuniqueness. These property realizations are then classified into facies probability cubes and ranked based on pay sand volumes to quantify the volumetric uncertainty in static reservoir modeling. Stochastic connectivity analysis was also applied on facies models to assess the possible connected volumes. Sand connectivity analysis showed that the connected pay sand volume derived from the posterior mean of property realizations, which is analogous to deterministic inversion, is much smaller than the volumes generated by any high-frequency realization. This observation supports the role of thin interbed reservoirs in facilitating connectivity between the main sand units.


1992 ◽  
Vol 11 (7) ◽  
pp. 589-590 ◽  
Author(s):  
William A. Bonadio ◽  
Lynn Stanco ◽  
Robert Bruce ◽  
Darcy Barry ◽  
Douglas Smith

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