Elevated Activity Levels Driving Technology Development at Record Pace: Barnett Shale--North Texas

2007 ◽  
Author(s):  
Drew Jennings ◽  
Floyd Carl Felderhoff ◽  
Matthew Ray Isbell ◽  
Mark Kramer ◽  
Eddie Pierce ◽  
...  
Keyword(s):  
Technology Development ◽  
Barnett Shale ◽  
Activity Levels ◽  
North Texas ◽  
Elevated Activity

Abstract 4998: Elevated Oxidized Phospholipids on Apolipoprotein B-100 Particles Predict 6-Year Cardiovascular Events in the Epic-Norfolk Study: Potentiation of Risk with Lipoprotein-Associated (Lp-PLA 2 ) and Soluble Phospholipase A2 (sPLA 2 ) Activity

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Sotirios Tsimikas ◽  
Ziad Mallat ◽  
Philippa J Talmud ◽  
John J Kastelein ◽  
Nicholas J Wareham ◽  
...  
Keyword(s):  
Activity Levels ◽  
Oxidized Phospholipids ◽  
Predictive Values ◽  
Men And Women ◽  
Atherosclerotic Lesions ◽  
Framingham Risk ◽  
Chd Risk ◽  
Elevated Activity ◽  
Traditional Risk Factors ◽  
Oxidative Biomarkers

Objective: We aimed to assess whether oxidized phospholipids on apoB-100 particles (OxPL/apoB) predict future coronary heart disease (CHD) in the prospective EPIC-Norfolk cohort of apparently healthy men and women aged 45–79 years followed up 1993–2007. Methods and Results: Cases who developed CHD during follow-up were matched to controls who remained free of cardiovascular disease and who matched to cases by sex, age and enrollment time. OxPL/apoB levels were measured with antibody E06 in 905 cases and 1809 controls. Subjects in the highest quartile of OxPL/apoB at entry in the study had significantly higher risk of future CHD events (OR 1.72, 95%CI 1.32–2.24, p<0.0001) compared to those in the lowest quartile. This relationship was present in both men and women and was also observed after adjustment for sex, age, diabetes, smoking, blood pressure, LDL-C, HDL-C and Framingham Risk Score (FRS). The risk of future CHD events was significantly potentiated by elevated activity levels of sPLA 2 and Lp-PLA 2 . Subjects in the highest tertiles of both OxPL/apoB and LpPLA2 (OR 2.22 [1.51–3.27]) or OxPL/apoB and sPLA 2 (OR 4.34 [2.84 – 6.64]) had significantly higher risk of future CHD than subjects in the lowest tertiles (p<0.0001 for both). Area under receiver operating curves revealed significantly increased values by adding OxPL/apoB and sPLA 2 to traditional risk factors and the FRS. Strong inverse associations were noted between the OxPL/apoB and VLDL and IDL size, CETP mass and RANK Ligand. Conclusion: Elevated OxPL/apoB levels are a strong, independent predictor of CHD events. The predictive values is further enhanced by elevated activity levels of sPLA 2 and Lp-PLA 2 , which mediate breakdown of OxPL present on lipoproteins and within atherosclerotic lesions. This study links several pathophysiologically related oxidative biomarkers in the prediction of CHD events and suggests novel approaches to predicting CHD risk in apparently health men and women.

New Cutter Technology Redefining PDC Durability Standards for Directional Control: North Texas/Barnett Shale

2010 ◽  
Author(s):  
Ryan Neil Baker ◽  
Yuelin Shen ◽  
John Zhang ◽  
Scott David Robertson
Keyword(s):  
Barnett Shale ◽  
North Texas ◽  
Directional Control

scholarly journals Exploring Disparities in Maternal Residential Proximity to Unconventional Gas Development in the Barnett Shale in North Texas

2019 ◽  
Vol 16 (3) ◽  
pp. 298
Author(s):  
Jennifer Ish ◽  
Elaine Symanski ◽  
Kristina Whitworth
Keyword(s):  
Low Income ◽  
White Women ◽  
Negative Binomial ◽  
Secondary Analysis ◽  
Negative Binomial Regression ◽  
Barnett Shale ◽  
North Texas ◽  
Unconventional Gas ◽  
Residential Proximity ◽  
Unconventional Gas Development

Background: This study explores sociodemographic disparities in residential proximity to unconventional gas development (UGD) among pregnant women. Methods: We conducted a secondary analysis using data from a retrospective birth cohort of 164,658 women with a live birth or fetal death from November 2010 to 2012 in the 24-county area comprising the Barnett Shale play, in North Texas. We considered both individual- and census tract-level indicators of sociodemographic status and computed Indexes of Concentration at the Extremes (ICE) to quantify relative neighborhood-level privilege/disadvantage. We used negative binomial regression to investigate the relation between these variables and the count of active UGD wells within 0.8 km of the home during gestation. We calculated count ratios (CR) and 95% confidence intervals (CI) to describe associations. Results: There were fewer wells located near homes of women of color living in low-income areas compared to non-Hispanic white women living in more privileged neighborhoods (ICE race/ethnicity + income: CR = 0.51, 95% CI = 0.48–0.55). Conclusions: While these results highlight a potential disparity in residential proximity to UGD in the Barnett Shale, they do not provide evidence of an environmental justice (EJ) issue nor negate findings of environmental injustice in other regions.

Inversion and attribute-assisted hydraulically induced microseismic fracture characterization in the North Texas Barnett Shale

2011 ◽  
Vol 30 (3) ◽  
pp. 292-299 ◽  
Author(s):  
Xavier E. Refunjol ◽  
Kurt J. Marfurt ◽  
Joël H. Le Calvez
Keyword(s):  
Barnett Shale ◽  
North Texas ◽  
Fracture Characterization ◽  
The North

Effects of Withdrawal from Chronic Amphetamine Administration on Activity Levels of Albino Rats

1974 ◽  
Vol 35 (1) ◽  
pp. 307-310 ◽  
Author(s):  
Vincent P. Houser ◽  
Dale A. Van Hart
Keyword(s):  
Activity Wheel ◽  
Albino Rats ◽  
Activity Levels ◽  
Baseline Activity ◽  
Amphetamine Administration ◽  
Middle Range ◽  
The Central Nervous System ◽  
Elevated Activity ◽  
Chronic Amphetamine ◽  
Amphetamine Sulfate

18 albino rats were administered either saline or various dosages of d-amphetamine sulfate in activity wheel cages over a 13-wk. period. Food consumption was decreased under the 2.0, 4.0 and 8.0 mg/kg dosages, while water consumption was reduced only under the highest dose. Motor activity was elevated under 1.0 mg/kg and was depressed under 8.0 mg/kg, while no reliable effects were noted under the middle range of doses. Withdrawal from 1.0 and 2.0 mg/kg of amphetamine led to significant elevations in baseline activity. These changes in activity could not be readily explained in terms of a simple conditioning process. It was suggested that amphetamine may produce long lasting changes in the central nervous system which are reflected in elevated activity when the drug is withdrawn.

scholarly journals Elevated activity levels of activating autoantibodies to the GnRH receptor in patients with polycystic ovary syndrome

F&S Reports ◽  
2020 ◽  
Vol 1 (3) ◽  
pp. 299-304
Author(s):  
Elizabeth A. Weedin ◽  
Heather R. Burks ◽  
Xichun Yu ◽  
Hong Liang Li ◽  
Christopher E. Aston ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Gnrh Receptor ◽  
Activity Levels ◽  
Ovary Syndrome ◽  
Elevated Activity ◽  
Activating Autoantibodies

scholarly journals Elevated activity levels do not influence extrinsic fiber attachment morphology on the surface of muscle‐attachment sites

2019 ◽  
Vol 236 (5) ◽  
pp. 827-839
Author(s):  
Cassandra M. Turcotte ◽  
David J. Green ◽  
Kornelius Kupczik ◽  
Shannon McFarlin ◽  
Ellen Schulz‐Kornas
Keyword(s):  
Activity Levels ◽  
Muscle Attachment ◽  
Attachment Sites ◽  
Elevated Activity ◽  
Muscle Attachment Sites

scholarly journals Parkin deficiency perturbs striatal circuit dynamics

2019 ◽  
Author(s):  
Magdalena K. Baaske ◽  
Edgar R. Kramer ◽  
Durga Praveen Meka ◽  
Gerhard Engler ◽  
Andreas K. Engel ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Mutant Mice ◽  
Projection Neurons ◽  
Activity Levels ◽  
Loss Of Function ◽  
Beta Oscillations ◽  
Field Coupling ◽  
Cell Type Specific ◽  
Elevated Activity ◽  
Fast Spiking

AbstractLoss-of-function mutations in the parkin-encoding PARK2 gene cause young-onset, autosomal recessive Parkinson’s disease (PD). Here, we investigated how parkin mutations affect cortico-basal ganglia circuit dynamics and cell-type-specific functional connectivity by recording simultaneously from motor cortex, striatum and globus pallidus (GP) in anesthetized parkin-mutant mice.While ongoing activity of presumed striatal spiny projection neurons and their downstream counterparts in the GP was not different from controls, parkin deficiency had a differential impact on striatal interneurons: In parkin-mutant mice, tonically active neurons displayed elevated activity levels. Baseline firing of transgenic striatal fast spiking interneurons (FSI), on the contrary, was reduced and the correlational structure of the FSI microcircuitry was disrupted. The entire transgenic striatal microcircuit showed enhanced and phase-shifted phase coupling to slow (1-3Hz) cortical population oscillations. Unexpectedly, local field potentials recorded from striatum and GP of parkin-mutant mice robustly displayed amplified beta oscillations (∼22Hz), phase-coupled to cortex. Moreover, parkin deficiency selectively increased spike-field coupling of FSIs to beta oscillations.Our findings suggest that loss of parkin function leads to amplifications of synchronized cortico-striatal oscillations and intrastriatal reconfiguration of interneuronal circuits. This presymptomatic disarrangement of dynamic functional connectivity may precede nigro-striatal neurodegeneration and predispose to imbalance of striatal outflow accompanying symptomatic PD.

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