scholarly journals The role of non-β-lactam antimicrobials and screening for vancomycin resistance in methicillin resistant Staphylococcus aureus

2011 ◽  
Author(s):  
Khan, F. ◽  
Shukla, I. ◽  
Rivzi, M.
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Vancomycin Resistance ◽  
Methicillin Resistant

Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model

2019 ◽  
Vol 21 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Yasushi Shibue ◽  
Soichiro Kimura ◽  
Chiaki Kajiwara ◽  
Yoichiro Iwakura ◽  
Keizo Yamaguchi ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Interleukin 17 ◽  
Methicillin Resistant ◽  
Staphylococcus Aureus Pneumonia

scholarly journals Role of Purine Biosynthesis in Persistent Methicillin-Resistant Staphylococcus aureus Infection

2018 ◽  
Vol 218 (9) ◽  
pp. 1367-1377 ◽  
Author(s):  
Liang Li ◽  
Wessam Abdelhady ◽  
Niles P Donegan ◽  
Kati Seidl ◽  
Ambrose Cheung ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Purine Biosynthesis ◽  
Methicillin Resistant ◽  
Aureus Infection

scholarly journals Synergism between β-Lactams and Glycopeptides against VanA-Type Methicillin-Resistant Staphylococcus aureus and Heterologous Expression of the vanA Operon

2006 ◽  
Vol 50 (11) ◽  
pp. 3622-3630 ◽  
Author(s):  
Bruno Périchon ◽  
Patrice Courvalin
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Inhibitory Concentration ◽  
Vancomycin Resistance ◽  
Glycopeptide Resistance ◽  
Methicillin Resistant ◽  
Antagonistic Effects ◽  
Resistance Induction ◽  
The Stability ◽  
Time Kill

ABSTRACT Vancomycin resistance of Staphylococcus aureus NY-VRSA and VRSA-5 is due to acquisition of a vanA operon located in a Tn1546-like element. The vanA gene cluster of NY-VRSA contained one copy of insertion sequences IS1251 and IS1216V relative to that of VRSA-5. As evidenced by the nature of the late peptidoglycan precursors and by quantification of d,d-peptidase activities, the vancomycin resistance genes were efficiently expressed in both strains. Study of the stability and inducibility of glycopeptide resistance suggested that low-level glycopeptide resistance of NY-VRSA was most probably due to plasmid instability combined with a long delay for resistance induction. The activity of combinations of vancomycin or teicoplanin with oxacillin against the four VanA-type S. aureus strains already reported was tested by single and double disk diffusion, E-test on agar alone or supplemented with antibiotics, the checkerboard technique, and by determining time-kill curves. A strong synergism against the four clinical isolates, with fractional inhibitory concentration indexes from 0.008 to 0.024, was reproducibly observed between the two antibiotics by all methods. These observations indicate that cell wall inhibitors of the β-lactam and glycopeptide classes exert strong and mutual antagonistic effects on resistance to each other against VanA-type methicillin-resistant S. aureus.

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