scholarly journals Magnesium affects poly(3-hydroxybutyrate-co-4-hydroxybutyrate) content and composition by affecting glucose uptake in Delftia acidovorans

2007 ◽  
Author(s):  
Lee, W. H. ◽  
Azizan, M. N. M. ◽  
Sudesh, K
Keyword(s):  
Glucose Uptake ◽  
Delftia Acidovorans

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia

2019 ◽  
Vol 476 (24) ◽  
pp. 3687-3704 ◽  
Author(s):  
Aphrodite T. Choumessi ◽  
Manuel Johanns ◽  
Claire Beaufay ◽  
Marie-France Herent ◽  
Vincent Stroobant ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Human Cancer ◽  
Glucose Production ◽  
Liver Mitochondria ◽  
New Drugs ◽  
Structural Isomer ◽  
Rat Liver Mitochondria ◽  
Ionization Mass ◽  
Ampk Activation ◽  
Starting Point

Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated AMPK were isolated. Compound 1 was identified as artelasticin by high-resolution electrospray ionization mass spectrometry and 2D-NMR while its structural isomer, compound 2, was isolated for the first time and differed only by the position of one double bond on one isoprenyl substituent. Treatment of MEFs with purified compound 1 or compound 2 led to rapid and robust AMPK activation at low micromolar concentrations and increased the intracellular AMP:ATP ratio. In oxygen consumption experiments on isolated rat liver mitochondria, compound 1 and compound 2 inhibited complex II of the electron transport chain and in freeze–thawed mitochondria succinate dehydrogenase was inhibited. In incubated rat skeletal muscles, both compounds activated AMPK and stimulated glucose uptake. Moreover, these effects were lost in muscles pre-incubated with AMPK inhibitor SBI-0206965, suggesting AMPK dependency. Incubation of mouse hepatocytes with compound 1 or compound 2 led to AMPK activation, but glucose production was decreased in hepatocytes from both wild-type and AMPKβ1−/− mice, suggesting that this effect was not AMPK-dependent. However, when administered intraperitoneally to high-fat diet-induced insulin-resistant mice, compound 1 and compound 2 had blood glucose-lowering effects. In addition, compound 1 and compound 2 reduced the viability of several human cancer cells in culture. The flavonoids we have identified could be a starting point for the development of new drugs to treat type 2 diabetes.

Opuntia leucotricha possesses insulin-like activities inducing glucose uptake in murine and human normal and diabetic-like adipocytes

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
R Zapata-Bustos ◽  
AJ Alonso-Castro ◽  
J Romo-Yañez ◽  
LA Salazar-Olivo
Keyword(s):  
Glucose Uptake

Beneficial effects of carrots (Daucus carota) on adipocyte differentiation, glucose uptake, and fat accumulation

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
K Christensen ◽  
D Kotowska ◽  
L Olsen ◽  
S Bhattacharya ◽  
X Fretté ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Daucus Carota ◽  
Adipocyte Differentiation ◽  
Fat Accumulation ◽  
Beneficial Effects

Active components isolated from Trapa natants increase glucose uptake in C2C12 myotubes

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
HC Huang ◽  
CL Chao ◽  
SY Hwang ◽  
TC Chang ◽  
CH Chao ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
C2c12 Myotubes ◽  
Active Components ◽  
Increase Glucose Uptake

Visual and quantitative approach to bone marrow foci of increased glucose uptake on PET/CT in a case of aplastic anaemia

2010 ◽  
Vol 49 (02) ◽  
pp. N10-N12 ◽  
Author(s):  
F. Cicone ◽  
M. Stalder ◽  
D. Geiger ◽  
A. Cairoli ◽  
A. Bischof Delaloye ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Glucose Uptake ◽  
Aplastic Anaemia ◽  
Quantitative Approach ◽  
Pet Ct

Targeting inflammation in ulcerative colitis by inhibition of glucose uptake

2018 ◽  
Vol 56 (08) ◽  
pp. e200-e201
Author(s):  
H Jodeleit ◽  
O Al-amodi ◽  
J Caesar ◽  
C Villarroel Aguilera ◽  
L Holdt ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Glucose Uptake

Testosterone stimulates glucose uptake in HepG2 liver cells

2014 ◽  
Author(s):  
Daniel Kelly ◽  
Samia Akhtar ◽  
Susannah Bowskill ◽  
Zoe Smallwood ◽  
Hugh Jones
Keyword(s):  
Glucose Uptake ◽  
Liver Cells

Exemplar Abstract for Delftia acidovorans (den Dooren de Jong 1926) Wen et al. 1999.

2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Dorothea Taylor ◽  
George M Garrity
Keyword(s):  
Delftia Acidovorans
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