scholarly journals A Five-Year Review of Soft Tissue Tumors with Intermediate Malignant Potential and Soft Tissue Sarcomas in a Tertiary Hospital: University of the Philippines – Philippine General Hospital

2021 ◽  
Vol 6 (1) ◽  
pp. 31-42
Author(s):  
Joeanne Marie Salise ◽  
◽  
Jenny Maureen Atun
Keyword(s):  
Soft Tissue ◽  
General Hospital ◽  
Soft Tissue Sarcomas ◽  
Tertiary Hospital ◽  
Soft Tissue Tumors ◽  
The Philippines ◽  
Malignant Potential

scholarly journals Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance

2016 ◽  
Vol 50 ◽  
pp. 15-23 ◽  
Author(s):  
Takashige Momose ◽  
Yasuo Yoshimura ◽  
Satoru Harumiya ◽  
Ken'ichi Isobe ◽  
Munehisa Kito ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Chondroitin Sulfate ◽  
Soft Tissue Sarcomas ◽  
Malignant Potential

The Frequency and Distribution of Benign Soft tissue tumors in A Tertiary Hospital of Delhi

2018 ◽  
Vol 7 (7) ◽  
pp. 852-856
Author(s):  
Mahapatra Qury S. ◽  
◽  
Lamba Sangeeta ◽  
Nanda Annu ◽  
Sethi Divya ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tertiary Hospital ◽  
Soft Tissue Tumors ◽  
Benign Soft Tissue Tumors

Epithelioid Hyalinizing Sarcoma With MGA-NUTM1 Fusion

2020 ◽  
Vol 154 (6) ◽  
pp. 859-866
Author(s):  
Caroline I M Underwood ◽  
Diana M Cardona ◽  
Rex C Bentley ◽  
Guomiao Shen ◽  
Xiaojun Feng ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Immunohistochemical Study ◽  
Soft Tissue Sarcomas ◽  
Soft Tissue Tumors ◽  
Molecular Testing ◽  
Molecular Alterations ◽  
Poorly Differentiated ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

Abstract Objectives Soft tissue sarcomas are a group of tumors derived from the mesenchymal origin. Historically, they have been classified according to morphologic and immunohistochemical characteristics. The advent of multiplexed next-generation sequencing (NGS), specifically RNA sequencing, has modified the classification of such tumors and others by determining categorization based on molecular alterations. The NUTM1 rearrangement, previously thought to be present only in carcinomas, has recently been reported in poorly differentiated high-grade sarcomas of the soft tissue. We present the first reported case of an epithelioid hyalinizing sarcoma harboring the MGA-NUTM1 fusion in an acral site. Methods Histopathologic, immunohistochemical, and molecular testing were performed on resection tissue. Results Histologically, the tumor showed an epithelioid morphology with prominent background hyalinization. Immunohistochemically, the tumor expressed CD99 and nuclear NUT-1. By NGS the tumor harbors MGA-NUTM1 fusion. Conclusions Our findings support more extensive use of NGS for accurate sarcoma classification and identification of potential therapeutic targets. Furthermore, they corroborate the fact that NUTM1-rearranged soft tissue tumors represent a spectrum of heterogeneous morphologic entities. This case also highlights the utility of NUT-1 immunohistochemical study as a possible screening tool for NUTM1-fused sarcomas.

Aberrant Immunohistochemical Expression in Nonrhabdomyosarcoma Soft Tissue Sarcomas of Infancy: Retrospective Review of Clinical Material

2002 ◽  
Vol 5 (6) ◽  
pp. 579-586 ◽  
Author(s):  
Neil James Sebire ◽  
Alan Drummond Ramsay ◽  
Gillian Levitt ◽  
Marian Malone ◽  
Rupert Anthony Risdon
Keyword(s):  
Soft Tissue ◽  
Smooth Muscle Actin ◽  
Diagnostic Category ◽  
Young Patients ◽  
Soft Tissue Sarcomas ◽  
Mitotic Rate ◽  
Soft Tissue Tumors ◽  
Undifferentiated Sarcoma ◽  
Infantile Fibrosarcoma ◽  
Infantile Hemangiopericytoma

Malignant soft tissue tumors other than rhabdomyosarcoma (RMS) are uncommon in infancy, representing approximately 5% of pediatric sarcomas. The pathological categorization of non-RMS soft tissue malignancies from these young patients is complicated by variation in both morphologic and immunohistochemical features. A search covering an 11-year period identified 19 patients presenting at birth or in infancy with a clinical or referral diagnosis of soft tissue sarcoma. After histologic and immunohistochemical review, nine of these tumors were classified as primitive neuroectodermal tumor (PNET), three as infantile hemangiopericytoma (HPC), two as infantile fibrosarcoma (FS), and five as undifferentiated sarcoma. Those identified as undifferentiated sarcomas showed an atypical spindle and ovoid cell morphology, with cellular pleomorphism and high mitotic rate, but lacking the fascicular growth pattern of classic infantile fibrosarcoma. Immunohistochemical staining in this group showed variable weak positivity for a range of markers (desmin, smooth muscle actin, Myo-D1, PGP, NSE, S100, CO56, cytokeratin, and CD99), and did not fit readily into any distinct diagnostic category. In this series, tumors classified as soft tissue PNETs had a poor prognosis despite aggressive treatment. However, once RMS, PNET, and other rare specific lesions are excluded, the remaining undifferentiated sarcomas, despite their unusual morphology and immunohistochemistry, appear to behave in a similar favorable manner to infantile fibrosarcoma.

Reasons for hospitalization and factors of mortality in patients with Parkinson's disease in the Philippines

2021 ◽  
Author(s):  
Adrian I Espiritu ◽  
Ma. Margarita Anna C Brillantes ◽  
Allister Vincent G Layog ◽  
Roland Dominic G Jamora
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Urinary Tract ◽  
Soft Tissue ◽  
Retrospective Review ◽  
Medical Records ◽  
Tertiary Hospital ◽  
The Philippines ◽  
Soft Tissue Infections ◽  
Common Cause

Aim: We aimed to determine the reasons for hospitalizations and factors of mortality of Filipino Parkinson's disease (PD) patients in a tertiary hospital. Methods: We conducted a retrospective review of medical records of PD patients admitted to our institution between 2016 and 2018. Demographic and clinical data were analyzed. Results: We included 166 PD patients. The most common cause of admission was infectious (pneumonia, urinary tract, and skin-soft tissue infections) (n = 65, 39.2%). The most common cause of mortality was sepsis (n = 9, 5.4%). Renal comorbidity was a significant factor of mortality (OR: 3.67, 95% CI: 1.11–12.12; p = 0.033). Conclusion: Interventions designed to reduce the risk of complications in PD patients should be prioritized to potentially decrease the probability of eventual hospitalization.

Surgical Management and Minimally Invasive Approaches for the Treatment of Metastatic Sarcoma

2013 ◽  
pp. 457-464
Author(s):  
Peter Hohenberger ◽  
Bernd Kasper ◽  
Kamran Ahrar
Keyword(s):  
Soft Tissue ◽  
Minimally Invasive ◽  
Early Stage ◽  
Tumor Biology ◽  
Local Treatment ◽  
Soft Tissue Sarcomas ◽  
Metastatic Tumor ◽  
Soft Tissue Tumors ◽  
Tumor Spread ◽  
Systemic Treatments

Soft tissue sarcomas describe a very heterogeneous group of soft tissue tumors mainly arising in the lower extremities. If diagnosed at an early stage and a complete resection of the primary tumor is achieved, the patients' prognosis is excellent. However, metastatic tumor spread is common with only limited treatment possibilities. Despite an improved insight into tumor biology of sarcomas, no notable improvement has been gained in the last 20 years regarding prognosis of patients. Metastatic lung disease has long been the preserve of systemic treatments, local treatments being considered in a purely palliative intention. Several studies have objectified benefit to the local treatment of metastases, especially in an oligometastatic state. The development of techniques for stereotactic radiotherapy on the one hand and the refusal or contraindication for surgery on the other hand inaugurated studies in this direction. Besides surgery and radiotherapy, other local modalities have been investigated in the last few years such as thermal therapy (radiofrequency and laser ablation) or combined modalities (isolated limb perfusion and deep-wave hyperthermia plus chemotherapy) to help patients with metastatic soft tissue sarcoma. Minimally invasive, image-guided therapies such as thermal ablation should be considered particularly in patients who are not suitable surgical candidates or may have exhausted all other viable surgical options. Some of these techniques will be reviewed in this article, and their value for the patients will be evaluated in the light of indication from tumor biology and technical feasibility. These highly selected and specific procedures should only be performed after decision making in an interdisciplinary sarcoma-board.

scholarly journals Giant Lipoma of Posterior Cervical Region

2014 ◽  
Vol 2014 ◽  
pp. 1-2
Author(s):  
Mahendra Singh ◽  
Ashish Saxena ◽  
Lovekesh Kumar ◽  
Snehal K. Karande ◽  
Yuvraj Kolhe
Keyword(s):  
Soft Tissue ◽  
Rare Case ◽  
Neck Region ◽  
Soft Tissue Tumors ◽  
Malignant Potential ◽  
Cervical Region ◽  
Head And Neck Region ◽  
Giant Lipoma ◽  
Benign Nature ◽  
Slow Growing

Lipomas are the slow growing soft tissue tumors of benign nature. They commonly grow on torso and extremities but may also develop in head and neck region. Rarely lipomas can grow to acquire gigantic proportions, turning into an entity termed as giant lipoma. Such lipomas are entitled to immediate attention as they have a relatively high malignant potential. We report a rare case of giant cervical lipoma in an elderly gentleman, followed by a brief discussion on diagnosis and management of the disorder.

Soft tissue tumors of the urinary bladder, part I: myofibroblastic proliferations, benign neoplasms, and tumors of uncertain malignant potential

2007 ◽  
Vol 38 (6) ◽  
pp. 807-823 ◽  
Author(s):  
Sarah Lott ◽  
Antonio Lopez-Beltran ◽  
Gregory T. MacLennan ◽  
Rodolfo Montironi ◽  
Liang Cheng
Keyword(s):  
Soft Tissue ◽  
Urinary Bladder ◽  
Soft Tissue Tumors ◽  
Malignant Potential ◽  
Benign Neoplasms ◽  
Uncertain Malignant Potential
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