scholarly journals The Relationships of Sex Hormone Binding Globulin(SHBG) with High Density Lipoprotein Cholesterol and Fasting Insulin in Healthy Men.

1993 ◽  
Vol 12 (5) ◽  
pp. 297-300
Author(s):  
Shuzo KUMAGAI ◽  
Haruka SASAKI ◽  
Naoko SHONO ◽  
Yosihiko MORIYAMA ◽  
Kotaro KATAKABE
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Sex Hormone ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Sex Hormone Binding Globulin ◽  
Fasting Insulin ◽  
Hormone Binding ◽  
Healthy Men

Relation between plasma high-density lipoprotein cholesterol and sex hormone concentrations in men

1984 ◽  
Vol 53 (9) ◽  
pp. 1259-1263 ◽  
Author(s):  
Wanju S. Dai ◽  
James P. Gutai ◽  
Lewis H. Kuller ◽  
Ronald E. Laporte ◽  
Lorita Falvo-Gerard ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Sex Hormone ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Plasma High Density Lipoprotein ◽  
Plasma High Density

scholarly journals Racial Disparities in Metabolism, Central Obesity, and Sex Hormone-Binding Globulin in Postmenopausal Women1

2001 ◽  
Vol 86 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Dora M. Berman ◽  
Lori M. Rodrigues ◽  
Barbara J. Nicklas ◽  
Alice S. Ryan ◽  
Karen E. Dennis ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Fat Mass ◽  
High Density Lipoprotein Cholesterol ◽  
Insulin Response ◽  
Density Lipoprotein ◽  
Free Testosterone ◽  
Sex Hormone Binding Globulin ◽  
Fasting Insulin ◽  
Hormone Binding ◽  
The Relationship

Increased total and intraabdominal fat (IAF) obesity as well as other metabolic conditions associated with the insulin resistance syndrome (IRS) are related to low levels of sex hormone-binding globulin (SHBG) in young and older Caucasian (CAU) and young African-American (AA) women. We examined whether postmenopausal AA women, a population with a high incidence of obesity and IRS despite low IAF, would have higher levels of circulating SHBG compared with CAU women, and whether there would be negative relationships between indexes of obesity and risk factors associated with IRS and SHBG levels. We measured body composition, SHBG, free testosterone, leptin, glucose tolerance, insulin, and lipoprotein lipids in 55 CAU (mean ± sd, 59 ± 7 yr) and 35 AA (57 ± 6 yr) sedentary women of comparable obesity (48% body fat, by dual energy x-ray absorptiometry). Compared with CAU women, AA women had larger waist (101 vs. 96 cm), larger fat mass (44.9 ± 8.8 vs. 39.9 ± 8.1 kg), larger sc fat area (552± 109 vs. 452 ± 109 cm2), and lower IAF/SC ratio (0.28 ± 0.12 vs. 0.38 ± 0.15; P < 0.01), but similar waist to hip ratio (0.83). Both groups had similar SHBG (117 vs. 124 nmol/L) and free testosterone (3.7 vs. 3.4 pmol/L) levels, but AA women had a 35% higher leptin, 34% higher fasting insulin, and 39% greater insulin response to a glucose load (P < 0.05) compared with CAU women. In CAU, but not AA, women SHBG correlated negatively with body mass index (r = −0.28; P < 0.05), waist (r = −0.36; P = 0.01), IAF (r = −0.34; P = 0.01), and insulin response to oral glucose (r = −0.37; P < 0.05) and positively with high density lipoprotein cholesterol (r = 0.30; P = 0.03). The relationship between insulin area and SHBG in CAU women disappeared after adjusting for IAF, whereas the relationship between high density lipoprotein cholesterol and SHBG persisted after adjusting for IAF, but not for fat mass. Leptin was positively related to fat mass (P < 0.05) in both groups, but it was related to insulin only in the Caucasian women (P < 0.01). There was a racial difference in the slopes (P < 0.05) of the relationships of leptin to fat mass (P < 0.05). Racial differences in leptin disappeared after adjustment for fasting insulin. These results suggest that the metabolic relationships between total and regional obesity, glucose, and lipid metabolism with SHBG in CAU women are different from those in postmenopausal obese AA women.

Differences in serum lipids, lipoproteins, sex hormone binding globulin and testosterone between the follicular and the luteal phase of the menstrual cycle

1993 ◽  
Vol 129 (2) ◽  
pp. 130-133 ◽  
Author(s):  
Charles PT Schijf ◽  
Marius J van der Mooren ◽  
Wim H Doesburg ◽  
Chris MG Thomas ◽  
Rune Rolland
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Luteal Phase ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Sex Hormone Binding Globulin ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Fifty-four healthy women were studied during the follicular and the luteal phase of one menstrual cycle to determine possible cyclic influences on several parameters. After a 12-h overnight fast, blood samples were obtained between 08.00 h and 09.30 h and processed for total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoproteins A-I and B and total triglycerides. In the same samples we also measured serum concentrations of follicle-stimulating hormone, luteinizing hormone, 17β-oestradiol, progesterone, sex hormone binding globulin and testosterone. Serum total cholesterol, low-density lipoprotein cholesterol and the related apolipoprotein B were decreased significantly with 0.35 mmol/l, 0.44 mmol/l and 15 mg/l, respectively, during the luteal phase as compared to the follicular phase (p≤0.01). The ratios of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and of total cholesterol/high-density lipoprotein cholesterol were also significantly lower (p <0.01) in the luteal phase because high-density lipoprotein cholesterol and its major carrier apolipoprotein A-I as well as serum triglycerides remained unchanged in the two cycle phases compared. Sex hormone binding globulin was significantly higher (p <0.001) in the luteal phase than in the follicular phase of the investigated cycles, whereas serum testosterone remained unchanged in the two cycle phases compared. Therefore, the free androgen index decreased in the luteal phase (p<0.01). These results indicate the necessity to define the cycle phase in which blood has been collected during control cycles in studies concentrating on possible effects of oral contraceptives or other administered sex steroids on serum lipids, lipoproteins and androgen metabolism. Further, we suggest that variations in the serum concentrations of lipids and lipoproteins during the normal menstrual cycle should be considered when normal range values are defined.

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