scholarly journals Birth-weight and Risk of Breast Cancer: A Systematic Review Study

2018 ◽  
Vol 2 (1) ◽  
pp. 11-24
Author(s):  
Stephenson Babatunde Ojeifo ◽  
Seun Stephen Anjorin
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Birth Weight ◽  
Meta Analysis ◽  
Computer Software ◽  
Premenopausal Women ◽  
High Birth Weight ◽  
Developmental Origin ◽  
Increased Risk ◽  
Level Of Risk

Introduction: Observational studies have linked the risk of breast cancer to birth weight, however, findings are not consistent. Therefore, the objective of this study was to investigate and quantify the level of risk of breast cancer associated with birth-weight among women. Methodology: A systematic search of literature was conducted from 1990-2016 using the following databases: PUBMED, DH-Data, EMBASE, MEDLINE, PSYCINFO and GOOGLE SCHOLAR. 13 relevant articles were identified for the systematic review, out of which 5 were suitable for meta-analysis. The computer software Review Manager (RevMan) 5.2 was used for the meta-analysis. Results: Most of the studies reviewed reported significant increased risk of breast cancer among participants with high birth weight. There were indications that this relationship is more pronounced among premenopausal women. In addition, the meta-analysis further revealed that women with suboptimum birth-weight (<3,500g) are at lesser risk of breast cancer when compared with optimum birth-weight 3,500g-4,500g (OR= 1.17 (95% CI 0.98, 1.39)); while optimum birth-weight (3,500g-4,500g) women are at lesser risk of breast cancer when compared with women with above-optimum birth-weight (>4,500g) (OR=0.87 (95% CI 0.66, 1.15). Conclusion and Implications for Translation: This study revealed that the risk of breast cancer increases with increasing high birth weight especially among premenopausal women, thus suggesting early onset of breast cancer in this group. There is a clear relationship between high birth weight and risk of breast cancer; the developmental origin of health and diseases theory as postulated by Baker may be the strongest biological mechanism to explain this finding. Prevention programs through health education and early diagnosis strategies targeted at this group might be promising strategies to tackle global burden of breast cancer. Key words: • Breast cancer • Birth-weight • Level of risk • Developmental origin of disease • Systematic review Copyright © 2018 Ojeifo and Anjorin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 

O-075 The association between high birth weight and long-term outcomes-implications for Assisted Reproductive Technologies: a systematic review and meta-analysis

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Å Magnusson ◽  
H Laivouri ◽  
A Loft ◽  
N Oldereid ◽  
A Pinborg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Birth Weight ◽  
Psychiatric Disorders ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
High Birth Weight ◽  
Increased Risk ◽  
Meta Analyses

Abstract Study question Do high birth weight or large for gestational age (LGS) increase the risk of serious disease later in life? Summary answer High birth weight and/or LGA were associated with elevated risks for certain child malignancies, breast cancer, psychiatric disorders, childhood hypertension and diabetes type 1. What is known already Previous studies have shown that children born after frozen embryo transfer (FET) have an increased risk of being born LGA or having a high birth weight. In recent years the practice of FET in Assisted Reproductive Technology (ART) has increased rapidly. The perinatal risks of being born LGA or with a high birth weight are well studied, however less is known about the impact on long-term health and morbidity. Study design, size, duration Pubmed, Scopus and Web of Science were searched until December 2020. 11 748 abstracts were screened, 172 publications were selected for systematic review and 63 for meta-analyses. The methodological quality in terms of risk of bias was assessed by pairs of reviewers. Robin-I (www.methods.cochrane.org) was used for assessing risk of bias in original articles. For systematic reviews AMSTAR was used. For certainty of evidence the GRADE system was used. Participants/materials, setting, methods Exposures were LGA and high birth weight. Long-term morbidity outcomes were cancer, metabolic disease, cardiovascular disease and psychiatric disorders. Cancer was focused on breast cancer, child malignancies in the central nervous system (CNS), hematological malignancies and Wilm´s tumor. Metabolic diseases included diabetes type 1 and type 2. Cardiovascular diseases were focused on hypertension and other cardiovascular disorders and psychiatric disorders on schizophrenia/psychosis and cognitive disorders. Main results and the role of chance Pooled Adjusted Odds Ratios (AOR) for outcome variables were compared for birth weights &gt;4000 or &gt; 4500 g versus &lt; 4000 g. For cancer, meta-analyses showed AOR of 1.24 (95% 1.11-1.39) for development of breast cancer, AOR of 1.15 (95% CI 1.05-1.27) for development of CNS tumors, AOR of 1.29 (95% CI 1.20-1.39) for childhood leukemia and AOR 1.68 (95% CI 1.38-2.06 ) for Wilm´s tumor. For metabolic disease a meta-analysis showed AOR of 1.15 (95%CI 1.05-1.26) for the association between high birth weight and type 1 diabetes. For psychiatric diseases an association was found between high birth weight and/or LGA and schizophrenia and depression. For cardiovascular disease, an association was found between high birth weight and hypertension in childhood with an inverse association in adulthood. No difference in the risk of coronary heart disease in adults born with high birth weight compared to normal birth Limitations, reasons for caution The main limitation is that all data are based on observational studies with their inborn risk of selection bias. Our conclusions are however, mainly based on meta-analyses and/or studies with low risk of bias. Wider implications of the findings Even though high birth weight and LGA are associated with an increased risk of serious diseases, both in childhood and in adulthood, the size of these effects seems modest. However, the identified risk associations should be taken into account in stimulation strategies and when considering fresh or frozen embryo transfer. Trial registration number Not applicable

The role of LHRH agonists in ovarian function preservation in premenopausal women undergoing chemotherapy for early stage breast cancer: A systematic review and meta-analysis.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 1050-1050
Author(s):  
Rodrigo Ramella Munhoz ◽  
Allan Andresson Lima Pereira ◽  
Andre Deeke Sasse ◽  
Paulo Marcelo Hoff ◽  
Tiffany A. Traina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Ovarian Function ◽  
Early Stage ◽  
Meta Analysis ◽  
Premenopausal Women ◽  
Early Stage Breast Cancer ◽  
Lhrh Agonists ◽  
Function Preservation

scholarly journals Pregnancy After Breast Cancer: A Systematic Review and Meta-Analysis

2021 ◽  
pp. JCO.21.00535
Author(s):  
Matteo Lambertini ◽  
Eva Blondeaux ◽  
Marco Bruzzone ◽  
Marta Perachino ◽  
Richard A. Anderson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
General Population ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Subsequent Pregnancy ◽  
Care Plan ◽  
Survivorship Care Plan ◽  
Reproductive Outcomes ◽  
Increased Risk

PURPOSE Many patients and physicians remain concerned about the potential detrimental effects of pregnancy after breast cancer (BC) in terms of reproductive outcomes and maternal safety. This systematic review and meta-analysis aimed at providing updated evidence on these topics. METHODS A systematic literature review was conducted to identify studies including patients with a pregnancy after BC (PROSPERO number CRD42020158324). Likelihood of pregnancy after BC, their reproductive outcomes, and maternal safety were assessed. Pooled relative risks, odds ratios (ORs), and hazard ratios (HRs) with 95% CIs were calculated using random effects models. RESULTS Of 6,462 identified records, 39 were included involving 8,093,401 women from the general population and 112,840 patients with BC of whom 7,505 had a pregnancy after diagnosis. BC survivors were significantly less likely to have a subsequent pregnancy compared with the general population (relative risk, 0.40; 95% CI, 0.32 to 0.49). Risks of caesarean section (OR, 1.14; 95% CI, 1.04 to 1.25), low birth weight (OR, 1.50; 95% CI, 1.31 to 1.73), preterm birth (OR, 1.45; 95% CI, 1.11 to 1.88), and small for gestational age (OR, 1.16; 95% CI, 1.01 to 1.33) were significantly higher in BC survivors, particularly in those with previous chemotherapy exposure, compared with the general population. No significantly increased risk of congenital abnormalities or other reproductive complications were observed. Compared to patients with BC without subsequent pregnancy, those with a pregnancy had better disease-free survival (HR, 0.66; 95% CI, 0.49 to 0.89) and overall survival (HR, 0.56; 95% CI, 0.45 to 0.68). Similar results were observed after correcting for potential confounders and irrespective of patient, tumor, and treatment characteristics, pregnancy outcome, and timing of pregnancy. CONCLUSION These results provide reassuring evidence on the safety of conceiving in BC survivors. Patients' pregnancy desire should be considered a crucial component of their survivorship care plan.

scholarly journals The associations of high birth weight with blood pressure and hypertension in later life: a systematic review and meta-analysis

2013 ◽  
Vol 36 (8) ◽  
pp. 725-735 ◽  
Author(s):  
Yong Zhang ◽  
Hui Li ◽  
Shang-jing Liu ◽  
Guang-jian Fu ◽  
Yong Zhao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Birth Weight ◽  
Meta Analysis ◽  
Later Life ◽  
High Birth Weight

scholarly journals The association between ATM variants and risk of breast cancer: a systematic review and meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Masoumeh Moslemi ◽  
Yousef Moradi ◽  
Hojat Dehghanbanadaki ◽  
Hamed Afkhami ◽  
Mansoor Khaledi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Predictive Ability ◽  
Case Control ◽  
Ataxia Telangiectasia Mutated ◽  
Case Control Studies ◽  
Predisposing Factor ◽  
Increased Risk ◽  
Atm Gene

Abstract Background Ataxia telangiectasia-mutated (ATM) gene contributes to repair damaged DNA and to regulate cell cycle; therefore, ATM variants seem to increase breast cancer risk; however, the results are controversial. So we conducted a systematic review and meta-analysis to clarify the pooled association between various ATM variants and the risk of breast cancer. Methods The relevant studies were searched through Scopus, Web of Science, PubMed and Cochrane. Stratified and subgroup analyses were performed to explore heterogeneity between studies and assess effects of study quality. The pooled estimates logarithm with standard error logarithm of odds ratio and relative risk with confidence interval were calculated. Results This study revealed that there is association between ATM variants and the risk of breast cancer; according to the seven adjusted case-control studies, OR of this association was estimated as 1.67 (95%CI: 0.73–3.82), according to nine unadjusted case-control studies, the crude OR was 2.27 (95% CI: 1.17–4.40) and according to two cohorts, the RR was estimated as 1.68 (95% CI: 1.17–2.40). Conclusions The ATM variants are associated with an increased risk of breast cancer that ATM V2424G mutation is detected as the most predisposing factor while ATM D1853V, L546V, and S707P variants have the least predictive ability.

Birth weight and risk of coronary heart disease in adults: a meta-analysis of prospective cohort studies

2014 ◽  
Vol 5 (6) ◽  
pp. 408-419 ◽  
Author(s):  
S.-F. Wang ◽  
L. Shu ◽  
J. Sheng ◽  
M. Mu ◽  
S. Wang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Birth Weight ◽  
Confidence Interval ◽  
Lower Risk ◽  
Meta Analysis ◽  
Continuous Variable ◽  
High Birth Weight ◽  
Weighted Estimate ◽  
Increased Risk

Some studies have found a significant relationship between birth weight (BW) and the risk of coronary heart disease (CHD) in adulthood, but results were inconsistent. The purpose of this study was to characterize the association between BW and the risk of CHD in adults. Among 144 papers detected by our search, 27 papers provided data on the relationship between BW and CHD, of which 23 papers considered BW as a continuous variable, and 14 articles considered BW as a categorical variable for this meta-analysis. Based on 23 papers, the mean weighted estimate for the association between BW and the combined outcome of non-fatal and fatal CHD was 0.83 [95% confidence interval (CI), 0.80–0.86] per kilogram of BW (P<0.0001). Low birth weight (LBW<2500 g) was associated with increased risk of CHD [odds ratio (OR), 1.19; 95% confidence interval (CI), 1.11–1.27] compared with subjects with BW⩾2500 g. LBW, as compared with normal BW (2500–4000 g), was associated with increased risk of CHD (OR, 1.16; 95% CI, 1.08–1.25). High birth weight (HBW⩾4000 g) was associated with decreased risk of CHD (OR, 0.89; 95% CI, 0.81–0.98) compared with subjects with BW<4000 g. In addition, there was an indication (not quite significant) that HBW was associated with a lower risk of CHD (OR, 0.89; 95% CI, 0.79–1.01), as compared with normal BW. No significant evidence of publication bias was present. These results suggest that LBW is significantly associated with increased risk of CHD and a 1 kg higher BW is associated with a 10–20% lower risk of CHD.

scholarly journals Dioxins Exposure and the Risk of Breast Cancer: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 13 (2) ◽  
Author(s):  
Nematollah Jaafarzadeh Haghighi ◽  
Amal Saki Malehi ◽  
Zeinab Ghaedrahmat
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
English Language ◽  
Meta Analysis ◽  
Breast Cancer Mortality ◽  
Positive Association ◽  
Great Distance ◽  
Organic Chemical ◽  
Significant Positive Association ◽  
Increased Risk

Context: Dioxins and dioxin-like chemicals composed of 419 compounds are a large group of compounds, including polychlorinated di-benzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs). Dioxins are extremely persistent in the environment and disperse in a great distance from the emission source, and bioaccumulation in the food chain is one of their critical properties. The incidence of breast cancer among Iranian women is about 30 to 35 per 100,000 cases. The present study is a systematic review of published studies in English language to discover the relationship between exposure to dioxin compounds and breast cancer. Methods: We conducted a comprehensive literature review utilizing PubMed, Embase, Scopus, and ISI web of science databases. The MeSH-based keywords used included Organic Chemical (MeSH) OR Dioxins (MeSH) AND cancer (MeSH) OR Breast cancer (MeSH) AND Breast disease (MeSH). Results: The review of the literature indicated a significant positive association between dioxins exposure and the risk of breast cancer. Only in one study, breast cancer mortality rate was reported in terms of exposure to dioxins, and standardized mortality rates (SMRs) were determined. Conclusions: Although there were limitations in this study, statistical analyses in various epidemiological studies demonstrated that dioxins exposure is linked to an increased risk of breast cancer.

Risk of gastrointestinal and hepatic toxicities in patients with hormone receptor-positive HER2-negative breast cancer treated with CDK 4/6 inhibitors: A systematic review and meta-analysis of randomized controlled trials.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e18284-e18284
Author(s):  
Aung Tun ◽  
Kyaw Zin Thein ◽  
Yu Yu Thar ◽  
Asha Nayak ◽  
Elizabeth Guevara
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Adverse Effects ◽  
Meta Analysis ◽  
Controlled Trials ◽  
High Grade ◽  
Randomized Controlled ◽  
Hormone Receptor Positive ◽  
Relative Risks ◽  
Increased Risk

e18284 Background: CDK4/6 inhibitors are proven to be beneficial in patients with hormone receptor-positive HER2-negative breast cancer. Studies have suggested an increased risk of gastrointestinal (GI) events. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to determine the risk of GI and hepatic toxicities. Methods: We systematically conducted a comprehensive literature search using MEDLINE and EMBASE databases through January 1, 2017. RCTs that mention GI symptoms and/or elevation of liver enzymes as adverse effects were incorporated in the analysis. Mantel-Haenszel method was used to calculate the estimated pooled risk ratio with 95% confidence interval (CI). Results: Five RCTs with a total of 2021 patients were eligible for analysis. The study arm used palbociclib-letrozole, palbociclib-fulvestrant, and ribociclib-letrozole while the control arm used placebo with letrozole or fulvestrant. The relative risks of all-grade elevated AST was 2.6 (95% CI: 1.15–5.86; p = 0.02); all-grade elevated ALT: 2.82 (95% CI: 1.25–6.36; p = 0.01); all-grade stomatitis: 3.32 (95% CI: 2.09-5.28; p < 0000.1); all-grade nausea: 1.79 (95%CI: 1.25-2.58; p = 0.002); all-grade vomiting:1.55 (95% CI: 0.92-2.63; p = 0.10); and all-grade diarrhea: 1.59 (95% CI 1.28-1.98; p < 0.0001). The relative risks of high-grade elevated AST was 3.08 (95% CI: 1.42–6.67; p = 0.004); high-grade elevated ALT: 7.2 (95% CI: 2.81–18.43; p < 0.0001); high-grade stomatitis: 2.01 (95% CI: 0.22-18.02; p = 0.53); high-grade nausea: 0.76 (95%CI: 0.12-4.78; p = 0.77); high-grade vomiting: 0.88 (95% CI: 0.19-4.13; p = 0.87); and high-grade diarrhea: 1.23 (95% CI 0.52-2.92; p = 0.64). Conclusions: Our meta-analysis demonstrated that CDK 4/6 inhibitor-based regimens are associated with a higher risk of all-grade and high-grade elevated AST and ALT. Moreover, the regimen is associated with increased risk of all-grade stomatitis, nausea and diarrhea. Recognizing these adverse effects may help clinicians in delivering proper supportive care and thereby enhancing patients’ quality of life.

scholarly journals High Birth Weight Increases the Risk for Bone Tumor: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 12 (9) ◽  
pp. 11178-11195 ◽  
Author(s):  
Songfeng Chen ◽  
Lin Yang ◽  
Feifei Pu ◽  
Hui Lin ◽  
Baichuan Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Bone Tumor ◽  
Meta Analysis ◽  
High Birth Weight
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