scholarly journals Ebola Virus Disease Epidemic: What Can the World Learn and Not Learn from West Africa?

2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Romuladus Azuine
Keyword(s):  
West Africa ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
The World

Emergence of the Ebola Virus Disease in West Africa

2017 ◽  
pp. 163-177
Author(s):  
Samir Dervisevic
Keyword(s):  
West Africa ◽  
Ebola Virus ◽  
Virus Disease ◽  
Central Africa ◽  
Ebola Virus Disease ◽  
World Health ◽  
Viral Haemorrhagic Fever ◽  
The World ◽  
Viral Illness ◽  
Health Organization

This chapter gives an overview on the recent outbreak of Ebola Virus Disease in West Africa which has lasted for over seventeen months. The Ebola virus has been implicated as a causative agent of viral haemorrhagic fever occurring in Central Africa over the last thirty-nine years. However, the Ebola virus has not previously been recognised as an endemic virus causing outbreaks of viral illness in West Africa. The start of what was to become the largest Ebola virus disease (EVD) outbreak in known history was first reported to the World Health Organization (WHO) on the 23rd of March 2014 and since then it has transformed into an unprecedented and severe epidemic affecting the three countries of West Africa (Guinea, Liberia and Sierra Leone). The emergence of this lethal virus in a setting of profound poverty, a dysfunctional public-health and a weak government infrastructure alarmed the wider world and caused dread from an uncontrollable spread.

scholarly journals Characterisation of the T-cell response to Ebola virus glycoprotein amongst survivors of the 2013–16 West Africa epidemic

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
T. R. W. Tipton ◽  
Y. Hall ◽  
J. A. Bore ◽  
A. White ◽  
L. S. Sibley ◽  
...  
Keyword(s):  
T Cell ◽  
West Africa ◽  
Cell Response ◽  
Ebola Virus ◽  
Medical Condition ◽  
Virus Disease ◽  
T Cell Response ◽  
Ebola Virus Disease ◽  
Cell Phenotype ◽  
T Cell Epitopes

AbstractZaireebolavirus (EBOV) is a highly pathogenic filovirus which can result in Ebola virus disease (EVD); a serious medical condition that presents as flu like symptoms but then often leads to more serious or fatal outcomes. The 2013–16 West Africa epidemic saw an unparalleled number of cases. Here we show characterisation and identification of T cell epitopes in surviving patients from Guinea to the EBOV glycoprotein. We perform interferon gamma (IFNγ) ELISpot using a glycoprotein peptide library to identify T cell epitopes and determine the CD4+ or CD8+ T cell component response. Additionally, we generate data on the T cell phenotype and measure polyfunctional cytokine secretion by these antigen specific cells. We show candidate peptides able to elicit a T cell response in EBOV survivors and provide inferred human leukocyte antigen (HLA) allele restriction. This data informs on the long-term T cell response to Ebola virus disease and highlights potentially important immunodominant peptides.

scholarly journals Comparative phylogeography of African fruit bats (Chiroptera, Pteropodidae) provide new insights into the outbreak of Ebola virus disease in West Africa, 2014–2016

2016 ◽  
Vol 339 (11-12) ◽  
pp. 517-528 ◽  
Author(s):  
Alexandre Hassanin ◽  
Nicolas Nesi ◽  
Julie Marin ◽  
Blaise Kadjo ◽  
Xavier Pourrut ◽  
...  
Keyword(s):  
West Africa ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Fruit Bats ◽  
Comparative Phylogeography

scholarly journals Seroprevalence of Ebola virus infection in Bombali District, Sierra Leone

2017 ◽  
Author(s):  
Nadege Goumkwa Mafopa ◽  
Gianluca Russo ◽  
Raoul Emeric Guetiya Wadoum ◽  
Emmanuel Iwerima ◽  
Vincent Batwala ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
West Africa ◽  
Sierra Leone ◽  
Ebola Virus ◽  
Virus Disease ◽  
Asymptomatic Infection ◽  
Ebola Virus Disease ◽  
Efficient Immune Response ◽  
Ebola Virus Infection

A serosurvey of anti-Ebola Zaire virus nucleoprotein IgG prevalence was carried out among Ebola virus disease survivors and their Community Contacts in Bombali District, Sierra Leone. Our data suggest that the specie of Ebola virus (Zaire) responsible of the 2013-2016 epidemic in West Africa may cause mild or asymptomatic infection in a proportion of cases, possibly due to an efficient immune response.

scholarly journals Ebola virus disease: the ‘Black Swan’ in West Africa

2014 ◽  
Vol 45 (1) ◽  
pp. 2-5 ◽  
Author(s):  
Colin Brown ◽  
Paul Arkell ◽  
Sakib Rokadiya
Keyword(s):  
West Africa ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Black Swan

scholarly journals Unintended consequences of the ‘bushmeat ban’ in West Africa during the 2013–2016 Ebola virus disease epidemic

2018 ◽  
Vol 200 ◽  
pp. 166-173 ◽  
Author(s):  
Jesse Bonwitt ◽  
Michael Dawson ◽  
Martin Kandeh ◽  
Rashid Ansumana ◽  
Foday Sahr ◽  
...  
Keyword(s):  
West Africa ◽  
Ebola Virus ◽  
Virus Disease ◽  
Unintended Consequences ◽  
Ebola Virus Disease

scholarly journals Ebola virus disease control (in West Africa): an ecological, one health approach

2015 ◽  
Vol 21 ◽  
Author(s):  
Clement Adebajo Meseko ◽  
Adeniyi Olugbenga Egbetade ◽  
Shamsudeen Fagbo
Keyword(s):  
West Africa ◽  
Disease Control ◽  
One Health ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease

scholarly journals A systematic review and meta-analysis of patient data from the West Africa (2013–16) Ebola virus disease epidemic

2019 ◽  
Vol 25 (11) ◽  
pp. 1307-1314 ◽  
Author(s):  
A.M. Rojek ◽  
A. Salam ◽  
R.J. Ragotte ◽  
E. Liddiard ◽  
A. Elhussain ◽  
...  
Keyword(s):  
Systematic Review ◽  
West Africa ◽  
Ebola Virus ◽  
Virus Disease ◽  
Meta Analysis ◽  
Patient Data ◽  
Ebola Virus Disease ◽  
The West
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