scholarly journals Population and Public Health Implications of Child Health and Reproductive Outcomes Among Carrier Couples of Sickle Cell Disorders in Madhya Pradesh, Central India

2013 ◽  
Vol 2 (2) ◽  
Author(s):  
Ranbir Balgir
Keyword(s):  
Public Health ◽  
Child Health ◽  
Sickle Cell ◽  
Central India ◽  
Madhya Pradesh ◽  
Reproductive Outcomes ◽  
Health Implications ◽  
Sickle Cell Disorders ◽  
Population And Public Health

scholarly journals IS HEMOGLOBIN E GENE WIDELY SPREAD IN THE STATE OF MADHYA PRADESH IN CENTRAL INDIA? EVIDENCE FROM FIVE TYPICAL FAMILIES

2014 ◽  
Vol 6 (1) ◽  
pp. e2014060 ◽  
Author(s):  
R S Balgir
Keyword(s):  
Sickle Cell ◽  
Clinical Manifestations ◽  
Central India ◽  
Madhya Pradesh ◽  
Red Cell ◽  
Hemoglobin E ◽  
Vulnerable People ◽  
Hb E ◽  
Double Heterozygosity ◽  
First Time

Background: Red cell inherited hemoglobin anomalies are commonly encountered in the central region of India. These cause a public health concern due to high degree of morbidity, mortality, and fetal loss in the backward, underprivileged, and vulnerable people. Purpose: To report five typical families of hemoglobin E disorders identified for the first time in the state of Madhya Pradesh from central India. Methods: Out of a total of 445 couples/families (excluding the present study) with 1526 persons (848 males and 678 females) referred from a tertiary hospital in central India for investigations of anemia/hemoglobinopathies during the period from March 2010 to February 2014, we came across five typical rare couples/families of hemoglobin E disorders worthy of detailed investigations. Laboratory investigations were carried out following the standard procedures after cross checking for quality control from time to time. Results: For the first time, we have encountered nine cases of heterozygous hemoglobin E trait, two members with hemoglobin E-β-thalassemia (double heterozygosity), two cases of sickle cell-hemoglobin E disease (double heterozygosity), and none with homozygous hemoglobin E. Cases  of hemoglobin E trait, hemoglobin E-β-thalassemia, sickle cell-β-thalassemia and sickle cell-E disease showed moderate to severe anemia, and target cells, and reduced values of red cell indices like RBC, Hb level, HCT, MCV, MCH and MCHC, representing abnormal hematological profile and clinical manifestations before blood transfusion. Conclusions: Double heterozygosity for hemoglobinopathies such as occurrence of β-thalassemia mutation with structurally abnormal hemoglobins (Hb S and Hb E) is a rare entity, but occurs with severe clinical manifestations only in those areas or communities where these are highly prevalent, testifying the migrations and genetic admixture. Distribution of hemoglobin E and β-thalassemia in different districts of Madhya Pradesh indicates that abnormal Hb E gene has wide spread and needs prevention for the rehabilitation of vulnerable people in central India. 

scholarly journals Pulmonary tuberculosis: a public health problem amongst the Saharia, a primitive tribe of Madhya Pradesh, Central India

2010 ◽  
Vol 14 (8) ◽  
pp. e713-e716 ◽  
Author(s):  
Vikas G. Rao ◽  
Punnathanathu Gopalan Gopi ◽  
Jyothi Bhat ◽  
Nagamiah Selvakumar ◽  
Rajiv Yadav ◽  
...  
Keyword(s):  
Public Health ◽  
Pulmonary Tuberculosis ◽  
Health Problem ◽  
Public Health Problem ◽  
Central India ◽  
Madhya Pradesh

ABO Blood Groups and Sickle-cell Trait Investigations in Madhya Pradesh Indore District (Central India)

1966 ◽  
Vol 15 (4) ◽  
pp. 404-408 ◽  
Author(s):  
Narendra Kumar
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Central India ◽  
Blood Groups ◽  
Madhya Pradesh ◽  
Abo Blood Groups ◽  
Blood Samples ◽  
Mixed Sample ◽  
Pooled Data

SummaryBlood samples from five hundred and ninety five individuals belonging to Indore district of west Madhya Pradesh were tested for ABO blood groups, and two hundred and ninety three of them were tested for the sickle-cell trait.The investigated groups include: the Kadve Kulmi, the Khati, the Rami Mali, the Balai, the Bhil and a mixed sample of various castes. The aforesaid groups, within the district, are found to be homogeneous, as far as the ABO blood groups distributions are concerned. Frequencies for the O, A and B genes have been found to be 0.5251, 0.1587 and 0.3162, respectively, in the pooled data.Sickle-cell trait has been detected in the Balai, the Charmakar or Chamar and the Bhil.

scholarly journals Sickle cell disease in Madhya Pradesh, Central India: A comparison of clinical profile of sickle cell homozygote vs. sickle-beta thalassaemia individuals

Hematology ◽  
2016 ◽  
Vol 21 (9) ◽  
pp. 558-563 ◽  
Author(s):  
Rajiv Yadav ◽  
Monica Lazarus ◽  
Pawan Ghanghoria ◽  
MPSS Singh ◽  
Rasik Behari Gupta ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Central India ◽  
Madhya Pradesh ◽  
Clinical Profile ◽  
Cell Disease ◽  
Beta Thalassaemia

Sickle Cell Disease: Current Activities, Public Health Implications, and Future Directions

2007 ◽  
Vol 16 (5) ◽  
pp. 575-582 ◽  
Author(s):  
Melissa Creary ◽  
Dhelia Williamson ◽  
Roshni Kulkarni
Keyword(s):  
Public Health ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Future Directions ◽  
Health Implications

scholarly journals Prevalence of hemolytic anemia and hemoglobinopathies among the pregnant women attending a tertiary hospital in central India

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ranbir S. Balgir
Keyword(s):  
Health Care ◽  
Pregnant Women ◽  
Sickle Cell ◽  
Central India ◽  
The Body ◽  
Fetal Mortality ◽  
Mean Corpuscular Hemoglobin ◽  
Hemoglobin E ◽  
Hematological Indices ◽  
Sickle Cell Disorders

<p>Anemia in pregnancy is one of the causes of maternal morbidity and, maternal and fetal mortality in India. Hemoglobin transports oxygen to different parts of the body. Any defect in hemoglobin structure leads to its adverse functions. Screening of pregnant women for hemoglobinopahties helps in early intervention for reducing morbidity and mortality. Although the prevalence of hemoglobinopathies especially of the sickle cell disorders is high in Madhya Pradesh but any study on pregnant women is lacking. This study had set the objectives to find the prevalence of anemia and hemoglobin disorders in pregnant women, and to determine the health status through hematological indices profile in central India. Hospital based a cross-sectional study showed 12.26% prevalence of hemoglobinopathies among 416 pregnant women, the sickle cell trait being 7.45%, followed by β-thalassemia trait (2.89%), hemoglobin E trait (0.24%), and sickle cell disease (1.68%). About 88% of the pregnant women were found free of hemoglobinopathies. Of the 9.13% pregnant women included in the study were suffering from sickle cell disorders. However, the overall 47.11% anemia was observed in pregnant women, ranging in between 45% to 66% and seemed to show a reduction in anemia after nutritional supplementations and improvement in maternal health care at antenatal check up due to accessibility to medical health facilities. A comparison of hematological indices of pregnant women afflicted with and without sickle cell disorders have revealed much reduced hemoglobin level, red blood cells count, mean corpuscular volume, hematocrit, and mean corpuscular hemoglobin; and raised leucocytosis in sickle cell disorder cases than among the normal pregnant women. A more vigorous and realistic campaign of prophylactic regime of supplementations for these pregnant women and child health care is suggested.</p><p> </p><p>妊娠期贫血是印度产妇母体发病率以及母婴死亡率的原因之一。 血红蛋白将氧输送到身体的不同部位。 血红蛋白结构的任何缺陷都导致其功能不良。 孕妇的血红蛋白病筛查有助于早期干预，降低发病率和死亡率。 虽然血红蛋白病特别是镰状细胞病的患病率在中央邦较高，但对孕妇的任何研究都很缺乏。 本研究将目标设为找出孕妇贫血和血红蛋白病患病率，并通过印度中部的血液指标情况来确定健康状况。 医院基于一项横断面研究显示了416名孕妇中12.26%的血红蛋白病患病率，镰状细胞特征为7.45%，接下来是β地中海贫血特征（2.89%）、血红蛋白E特征（0.24%）和镰状细胞病（1.68%）。 约88%的孕妇被发现未患血红蛋白病。 纳入研究的孕妇有9.13%患有镰状细胞病。 然而，在孕妇中观察到总体47.11%的贫血，范围从45%到66%之间，在营养补充以及由于医疗卫生设施可及性原因在产前检查时孕妇健康护理改善后，看来显示出贫血的减少。 对患有或未患镰状细胞病的孕妇血液学指数的比较揭示出，镰状细胞症病的病例与正常孕妇相比血红蛋白水平、红细胞计数、平均红细胞容积、血细胞比容和平均红细胞血红蛋白有很大降低，以及有白细胞的增多。 建议对于这些孕妇和儿童的卫生护理的预防性补充方案采取更积极并且更切实际的活动。</p>

scholarly journals Doença falciforme e o teste do pezinho: implicações para a saúde pública

2019 ◽  
Vol 20 (3) ◽  
pp. 4-6
Author(s):  
Meirielli Vieira Bruzeguini ◽  
Maria Carmen Viana
Keyword(s):  
Public Health ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Health Implications ◽  
Blood Spot

Sickle Cell Disease and newborn blood spot screening: public health implications

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