scholarly journals General binary file parser.

2018 ◽  
Vol 3 (26) ◽  
pp. 766
Author(s):  
Jeroen F.J. Laros
Keyword(s):  
Author(s):  
William A Freyman ◽  
Kimberly F McManus ◽  
Suyash S Shringarpure ◽  
Ethan M Jewett ◽  
Katarzyna Bryc ◽  
...  

Abstract Estimating the genomic location and length of identical-by-descent (IBD) segments among individuals is a crucial step in many genetic analyses. However, the exponential growth in the size of biobank and direct-to-consumer (DTC) genetic data sets makes accurate IBD inference a significant computational challenge. Here we present the templated positional Burrows-Wheeler transform (TPBWT) to make fast IBD estimates robust to genotype and phasing errors. Using haplotype data simulated over pedigrees with realistic genotyping and phasing errors we show that the TPBWT outperforms other state-of-the-art IBD inference algorithms in terms of speed and accuracy. For each phase-aware method, we explore the false positive and false negative rates of inferring IBD by segment length and characterize the types of error commonly found. Our results highlight the fragility of most phased IBD inference methods; the accuracy of IBD estimates can be highly sensitive to the quality of haplotype phasing. Additionally we compare the performance of the TPBWT against a widely used phase-free IBD inference approach that is robust to phasing errors. We introduce both in-sample and out-of-sample TPBWT-based IBD inference algorithms and demonstrate their computational efficiency on massive-scale datasets with millions of samples. Furthermore we describe the binary file format for TPBWT-compressed haplotypes that results in fast and efficient out-of-sample IBD computes against very large cohort panels. Finally, we demonstrate the utility of the TPBWT in a brief empirical analysis exploring geographic patterns of haplotype sharing within Mexico. Hierarchical clustering of IBD shared across regions within Mexico reveals geographically structured haplotype sharing and a strong signal of isolation by distance. Our software implementation of the TPBWT is freely available for non-commercial use in the code repository https://github.com/23andMe/phasedibd.


2014 ◽  
Vol 940 ◽  
pp. 433-436 ◽  
Author(s):  
Ying Zhang ◽  
Xin Shi

Based on the detailed analysis of the STL file format, VC++ 6.0 programming language was used to extract the STL ASCII and binary file information, at the same time, using the OpenGL triangle drawing technology for graphical representation of the STL file, with rendering functions such as material, coordinate transformation, lighting, et al, finally realizing the loading and three-dimensional display of STL ASCII and binary file formats.


2014 ◽  
Vol 651-653 ◽  
pp. 1741-1747
Author(s):  
Xiao Lin Zhao ◽  
Gang Hao ◽  
Chang Zhen Hu ◽  
Zhi Qiang Li

With the increasing scale of software system, the interaction between software elements becomes more and more complex, which lead to the increased dirty data in running software system. This may reduce the system performance and cause system collapse. In this paper, we proposed a discovery method of the dirty data transmission path based on complex network. Firstly, the binary file is decompiled and the function call graph is drawn by using the source code. Then the software structure is described as a weighted directed graph based on the knowledge of complex network. In addition, the dirty data node is marked by using the power-law distribution characteristics of the scale-free network construction of complex network chart. Finally, we found the dirty data transmission path during software running process. The experimental results show the transmission path of dirty data is accurate, which confirmed the feasibility of the method.


2014 ◽  
Vol 18 (1/2014) ◽  
pp. 111-119 ◽  
Author(s):  
Marius POPA
Keyword(s):  

2011 ◽  
Vol 16 (34) ◽  
Author(s):  
L Hrivniaková ◽  
D Schmid ◽  
A Luckner-Hornischer ◽  
H Lassnig ◽  
C. Kornschober ◽  
...  

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2012 ◽  
Vol 17 (13) ◽  
Author(s):  
M S Arcilla ◽  
P J Wismans ◽  
Y van Beek-Nieuwland ◽  
P J van Genderen

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2013 ◽  
Vol 18 (17) ◽  
Author(s):  
S Gillesberg Lassen ◽  
B Soborg ◽  
S E Midgley ◽  
A Steens ◽  
L Vold ◽  
...  

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2014 ◽  
Vol 19 (20) ◽  
Author(s):  
T Braeckman ◽  
H Theeten ◽  
T Lernout ◽  
N Hens ◽  
M Roelants ◽  
...  

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2013 ◽  
Vol 18 (21) ◽  
Author(s):  
I Paradowska-Stankiewicz ◽  
M P Czarkowski ◽  
T Derrough ◽  
P Stefanoff

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2012 ◽  
Vol 17 (31) ◽  
Author(s):  
J Janiec ◽  
A Zielicka-Hardy ◽  
A Polkowska ◽  
J Rogalska ◽  
M Sadkowska-Todys

Binary file ES_Abstracts_Final_ECDC.txt matches


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