scholarly journals Vitamin D Receptor FokI Gene Polymorphism Predicted Poor Response to Treatment in Chronic HCV Genotype 4

2016 ◽  
Vol 6 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Hany Shehab ◽  
◽  
Dina Sabry ◽  
Mai Mukhtar ◽  
Wafaa Elakel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gene Polymorphism ◽  
Vitamin D Receptor ◽  
Poor Response ◽  
Response To Treatment ◽  
Genotype 4 ◽  
Hcv Genotype ◽  
Chronic Hcv

scholarly journals Relation of interleukin-1β gene to treatment response in chronic patients infected with HCV genotype 4

2013 ◽  
Vol 7 (11) ◽  
pp. 851-858 ◽  
Author(s):  
Moataza Hassan Omran ◽  
Noha E. Ibrahim ◽  
Samar S. Youssef ◽  
Basma E Fatouh ◽  
Wael Nabil ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Interferon Therapy ◽  
Strong Association ◽  
Response To Therapy ◽  
Interleukin 1Β ◽  
Response To Treatment ◽  
P Value ◽  
Chronic Patients ◽  
Genotype 4 ◽  
Chronic Hcv

Introduction: Hepatitis C virus (HCV) infection results in chronic hepatitis in more than 70% of infected patients, while 20-30% of patients recover spontaneously. This strengthens the role of the host genetic factors in either spontaneous or drug-induced viral clearance. The aim of this study was to investigate the relationship between interleukin-1β +3953 gene polymorphism and the response to interferon therapy in chronic HCV patients infected with genotype 4. Methodology: The interleukin-1β (+3953 C/T) (rs1143634) gene was amplified in 115 chronic HCV patients. Interleukin-1β single nucleotide polymorphism (SNP) plus several clinical and pathological factors were statistically analyzed in correlation with response to therapy. Results: Genotypes C/T and T/T had a significant association with non-response to treatment compared to genotype C/C, which had a strong association with response to treatment (95% confidence; 6.4884-48.5818, p = 0.0001). Furthermore, analysis of allele frequency in this cohort revealed that the T allele is associated with non-response, higher fibrosis, and higher hepatic activity, while the C allele had a significant association with sustained virologic response lower fibrosis, and lower hepatic activity (p value = 0.0001). Conclusion: This is the first study to examine the correlation between interleukin-1β (+3953 C/T) (rs1143634) gene polymorphism and the response of interferon therapy in genotype 4 HCV-infected patients. The results encourage further assessment of this SNP as a marker  to predict response to therapy and disease progression, which can have major implications in saving money, time, and in avoiding unnecessary adverse effects.

scholarly journals Association of Vitamin D Receptor BsmI Gene Polymorphism with Risk of Tuberculosis: A Meta-Analysis of 15 Studies

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66944 ◽  
Author(s):  
Yu-jiao Wu ◽  
Xin Yang ◽  
Xiao-xiao Wang ◽  
Man-Tang Qiu ◽  
Yi-zhong You ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gene Polymorphism ◽  
Vitamin D Receptor ◽  
Meta Analysis

Insulin resistance: a predictor for response to interferon-based therapy in Egyptian patients with chronic HCV genotype 4

2012 ◽  
Vol 23 (1) ◽  
pp. 7-13
Author(s):  
Sherif Mogawer ◽  
Mona Mansour ◽  
Mohamed Marie ◽  
Mervat El-Ansary ◽  
Samah Abd El-Hamid
Keyword(s):  
Insulin Resistance ◽  
Genotype 4 ◽  
Hcv Genotype ◽  
Egyptian Patients ◽  
Chronic Hcv
Sign in / Sign up

Export Citation Format

Share Document