scholarly journals Coexistence of asthmatic and non-respiratory allergic symptoms in children of Batumi Region, Georgia: occurrence and association with known diagnosis of asthma

2021 ◽  
Vol 29 (1) ◽  
pp. 23-27
Author(s):  
Vakhtang Beridze ◽  
Tamar Bakhtadze ◽  
Sophio Beridze ◽  
Karaman Phagava ◽  
Ivane Chkhaidze ◽  
...  
Keyword(s):  
Allergic Symptoms

scholarly journals Gastric Enzyme Supplementation Inhibits Food Allergy in a BALB/c Mouse Model

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 738
Author(s):  
Nazanin Samadi ◽  
Denise Heiden ◽  
Martina Klems ◽  
Martina Salzmann ◽  
Johanna Rohrhofer ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Gastric Acid ◽  
Clinical Symptoms ◽  
Acid Suppression ◽  
Gastric Digestion ◽  
Enzyme Solution ◽  
Allergic Symptoms ◽  
Gastric Acid Suppression ◽  
The Impact

Impaired gastric digestion due to suppressed gastric acidity enhances the risk for food allergy development. In the current study, we aimed to evaluate the impact of a supported gastric digestion via application of a pharmaceutical gastric enzyme solution (GES) on food allergy development and allergic reactions in a BALB/c mouse model. The ability of the GES to restore hypoacidic conditions was tested in mice treated with gastric acid suppression medication. To evaluate the impact on allergic symptoms, mice were orally sensitized with ovalbumin (OVA) under gastric acid suppression and subjected to oral challenges with or without GES. The immune response was evaluated by measurement of antibody titers, cytokine levels, mucosal allergy effector cell influx and regulatory T-cell counts. Clinical response was objectified by core body temperature measurements after oral OVA challenge. Supplementation of GES transiently restored physiological pH levels in the stomach after pharmaceutical gastric acid suppression. During oral sensitization, supplementation of gastric enzymes significantly reduced systemic IgE, IgG1 and IgG2a levels and allergic symptoms. In food allergic mice, clinical symptoms were reduced by co-administration of the gastric enzyme solution. Support of gastric digestion efficiently prevents food allergy induction and alleviates clinical symptoms in our food allergy model.

Association between ventilation rates in 390 Swedish homes and allergic symptoms in children

Indoor Air ◽  
2005 ◽  
Vol 15 (4) ◽  
pp. 275-280 ◽  
Author(s):  
C. G. Bornehag ◽  
J. Sundell ◽  
L. Hagerhed-Engman ◽  
T. Sigsgaard
Keyword(s):  
Allergic Symptoms ◽  
Ventilation Rates

scholarly journals Prevalence of allergic symptoms in young adults after wheezing during preschool

2020 ◽  
Vol 13 (8) ◽  
pp. 100210
Author(s):  
Bashir Omarjee ◽  
Serge Kah ◽  
Bernard Gregoire-Krikorian ◽  
Patrick Gros
Keyword(s):  
Young Adults ◽  
Allergic Symptoms

Citrobacter koseri stimulates dendritic cells to induce IL-33 expression via abundant ATP production

2021 ◽  
Author(s):  
Hideo Kataoka ◽  
Taiki Mori ◽  
Takeshi Into
Keyword(s):  
Dendritic Cells ◽  
Type Species ◽  
Food Allergies ◽  
Toll Like Receptor 4 ◽  
Content Type ◽  
Atp Production ◽  
Link Type ◽  
Allergic Symptoms ◽  
Live Bacteria ◽  
Mouse Dendritic Cell

Introduction. Food allergies (FAs) occur due to intestinal immune dysfunction elicited by dysbiotic conditions. It was previously determined by us that Citrobacter species propagate in the faeces of mice with FAs and worsen allergic symptoms by inducing the allergenic cytokine IL-33. Dendritic cells can play important roles in regulation of FA responses. Hypothesis. Citrobacter species propagating in intestines of mice worsen allergic symptoms by stimulating dendritic cells to induce IL-33 expression. Aim. The aim of the present study was to analyse whether C. koseri stimulates dendritic cells to induce IL-33 expression. Methodology. IL-33 expression was evaluated in a DC2.4 mouse dendritic cell line stimulated by live or heat-inactivated C. koseri JCM1658, ATP, LPS extracted from C. koseri JCM1658 or other enterobacteria by real-time PCR. The ATP concentration and number of live bacteria in the culture supernatant were measured simultaneously. Results. Live C. koseri JCM1658 induced higher levels of IL-33 expression than other enterobacteria tested, but such a response was not elicited by heat-inactivated C. koseri JCM1658. LPS extracted from C. koseri JCM1658 did not induce IL-33 expression and suppressed live C. koseri JCM1658-induced IL-33 expression via the activation of Toll-like receptor 4 signalling. Furthermore, ATP produced by C. koseri JCM1658 stimulated dendritic cells to induce IL-33 expression by stimulating the P2X7 receptor, and LPS attenuated extracellular ATP-induced IL-33 expression. C. koseri JCM1658 was observed to proliferate more vigorously and produce more ATP than other enterobacteria. Conclusion. C. koseri acts as an allergenic bacterium through ATP production, stimulating dendritic cells to induce IL-33 expression, while LPS released from inactivated C. koseri JCM1658 attenuates this allergenicity.

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