Forte Fortissimo for Amateur Musicians: No Effect on Otoacoustic Emissions

2013 ◽  
Vol 28 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Ole J Møllerløkken ◽  
Nils Magerøy ◽  
Magne Bråtveit ◽  
Ola Lind ◽  
Bente E Moen
Keyword(s):  
Otoacoustic Emissions ◽  
Office Workers ◽  
Cochlear Function ◽  
Distortion Product ◽  
Brass Band ◽  
Hearing Ability ◽  
Sound Levels ◽  
Amateur Musicians ◽  
Before And After ◽  
Noise Measurements

Many amateur musicians are likely to be exposed to high sound levels during rehearsals. Measuring otoacoustic emissions (OAE) is an objective technique to assess hearing ability and can be used as an early predictor of hearing loss. This study aimed to record sound levels at an amateur brass band rehearsal and to examine the cochlear function of the musicians by evaluating distortion product (DP) OAE amplitudes before and after sound exposure. Twenty-four brass band musicians and 10 office workers were examined with personal noise measurements and DPOAE tests before and after a music rehearsal or one office workday, respectively. The sound levels in the brass band ranged from 92 to 100 dB(A), LaEQ 96 dB(A). However, the amateur brass band members had no change in DPOAEs after this exposure compared to pre-exposure levels and compared to office workers.

Evaluating cochlear function and the effects of noise exposure in the B6.CAST+Ahl mouse with distortion product otoacoustic emissions

2004 ◽  
Vol 194 (1-2) ◽  
pp. 87-96 ◽  
Author(s):  
Ana E Vázquez ◽  
Ana M Jimenez ◽  
Glen K Martin ◽  
Anne E Luebke ◽  
Brenda L Lonsbury-Martin
Keyword(s):  
Otoacoustic Emissions ◽  
Noise Exposure ◽  
Distortion Product Otoacoustic Emissions ◽  
Cochlear Function ◽  
Distortion Product

Early Changes in Auditory Function As a Result of Platinum Chemotherapy: Use of Extended High-Frequency Audiometry and Evoked Distortion Product Otoacoustic Emissions

2007 ◽  
Vol 25 (10) ◽  
pp. 1190-1195 ◽  
Author(s):  
Kristin R. Knight ◽  
Dale F. Kraemer ◽  
Christiane Winter ◽  
Edward A. Neuwelt
Keyword(s):  
High Frequency ◽  
Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emissions ◽  
Auditory Function ◽  
Cochlear Function ◽  
Serial Measurement ◽  
Distortion Product ◽  
High Frequency Audiometry ◽  
Platinum Based Chemotherapy ◽  
Platinum Chemotherapy

Purpose The objective is to describe progressive changes in hearing and cochlear function in children and adolescents treated with platinum-based chemotherapy and to begin preliminary evaluation of the feasibility of extended high-frequency audiometry and distortion product otoacoustic emissions for ototoxicity monitoring in children. Patients and Methods Baseline and serial measurement of conventional pure-tone audiometry (0.5 to 8 kHz) and evoked distortion product otoacoustic emissions (DPOAEs) were conducted for 32 patients age 8 months to 20 years who were treated with cisplatin and/or carboplatin chemotherapy. Seventeen children also had baseline and serial measurement of extended high-frequency (EHF) audiometry (9 to 16 kHz). Audiologic data were analyzed to determine the incidence of ototoxicity using the American Speech-Language-Hearing Association criteria, and the relationships between the different measures of ototoxicity. Results Of the 32 children, 20 (62.5%) acquired bilateral ototoxicity in the conventional frequency range during chemotherapy treatment, and 26 (81.3%) had bilateral decreases in DPOAE amplitudes and dynamic range. Of the 17 children with EHF audiometry results, 16 (94.1%) had bilateral ototoxicity in the EHF range. Pilot data suggest that EHF thresholds and DPOAEs show ototoxic changes before hearing loss is detected by conventional audiometry. Conclusion EHF audiometry and DPOAEs have the potential to reveal earlier changes in auditory function than conventional frequency audiometry during platinum chemotherapy in children.

scholarly journals Cochlear function in patients with chronic kidney disease

2013 ◽  
Vol 60 (1) ◽  
Author(s):  
Samantha Marlanie Govender ◽  
Cyril Devdas Govender ◽  
Glenda Matthews
Keyword(s):  
Chronic Kidney Disease ◽  
Hearing Loss ◽  
Kidney Disease ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Drug Intake ◽  
Cochlear Function ◽  
Distortion Product ◽  
Cochlear Dysfunction

Objective: To evaluate cochlear functioning in patients (18 - 45 years old) with varying stages of chronic kidney disease (CKD). Using purposive sampling, 50 participants, 10 in each of the 5 stages of CKD, were selected and underwent pure tone audiometric testing and distortion product otoacoustic emissions (DPOAEs).Results: Significant differences (p<0.05) were found between pure tone audiometry and DPOAEs in detecting early cochlear dysfunction in the high-frequency range in stages 3 (6 000/5 000 Hz; p=0.00), 4 (6 000/5 000 Hz; p<0.03) and 5 (4 000/3 333 Hz; p<0.01, 8 000/6 667 Hz:p<0.05) with DPOAEs being more sensitive in identifying early cochlear dysfunction. Patients in stages 1 and 2 presented with normal puretone thresholds and DPOAEs, suggesting that cochlear functioning in these patients was normal. Early cochlear dysfunction, thereby indicating a subclinical hearing loss, was identified in stages 3, 4 and 5 by DPOAE testing. In addition, blood test results, drug intake and concomitant conditions were recorded and analysed which suggested a relationship between reduced cochlear functioning and increased electrolyte levels, treatment regimens and concomitant conditions.Conclusion: Participants in the later stages of CKD presented with early cochlear dysfunction, presenting with subclinical hearing loss. It was postulated that this subclinical hearing loss resulted from a combination of electrolytic, urea and creatinine imbalances, together with concomitant medical conditions and ototoxic drug intake. It was concluded that audiological monitoring be included in the management of patients with CKD and that DPOAEs be introduced as part of the test battery to monitor cochlear function in patients with varying degrees of CKD.

scholarly journals Time-domain analysis of distortion-product otoacoustic emissions using a hydrodynamic cochlea model

2017 ◽  
Vol 3 (2) ◽  
pp. 453-456
Author(s):  
Dennis Zelle ◽  
Ernst Dalhoff ◽  
Anthony W. Gummer
Keyword(s):  
Time Domain ◽  
Otoacoustic Emissions ◽  
Short Pulse ◽  
Human Subjects ◽  
Time Domain Analysis ◽  
Distortion Product Otoacoustic Emissions ◽  
Sound Waves ◽  
Cochlear Function ◽  
Distortion Product ◽  
The Time Domain

AbstractAs a by-product of nonlinear amplification in the cochlea, the inner ear emits sound waves in response to two tones with different frequencies. These sound waves are measurable in the ear canal as distortion-product otoacoustic emissions (DPOAEs). DPOAEs putatively consist of two components emerging at different locations in the cochlea. Wave interference between the two components limits the accuracy of DPOAEs as a noninvasive measure of cochlear function. Using short stimulus pulses instead of continuous stimuli, the two DPOAE components can be separated in the time domain due to their different latencies. The present work utilizes a nonlinear hydrodynamic cochlea model to simulate short-pulse DPOAEs in the time domain. When adding irregularities to the mechanical parameters of the model, the simulated DPOAE signals show two distinguishable components and long-lasting beat tones, similar to band-pass filtered experimental data from normal-hearing human subjects. The model results suggest that the beat tones can occur solely due to interference of the coherent-reflection component with the fading nonlinear-distortion component.

scholarly journals Predicting hearing loss from otoacoustic emissions using an artificial neural network

2002 ◽  
Vol 49 (1) ◽  
Author(s):  
Rouviere De Waal ◽  
René Hugo ◽  
Maggi Soer ◽  
Johann J. Krüger
Keyword(s):  
Neural Network ◽  
Artificial Neural Network ◽  
Otoacoustic Emissions ◽  
Back Propagation ◽  
Normal Hearing ◽  
Hearing Impaired ◽  
Distortion Product ◽  
Hearing Ability ◽  
Artificial Neural ◽  
Artificial Neural Network Ann

Normal and impaired pure tone thresholds (PTTs) were predicted from distortion product otoacoustic emissions (DP using a feed-forward artificial neural network (ANN) with a back-propagation training algorithm. The ANN used a present and absent DPOAEs from eight DP grams, (2fl -f2 = 406 - 4031 Hz) to predict PTTs at 0.5, 1, 2 and 4 kHz. With normal hearing as < 25 dB HL, prediction accuracy of normal hearing was 94% at 500, 88% at 1000, 88% at 2000 and 93% at 4000 Hz. Prediction of hearing-impaired categories was less accurate, due to insufficient data for the ANN to train on. This research indicates the possibility of accurately predicting hearing ability within 10 dB in normal hearing individuals and in hearing-impaired listeners with DPOAEs and ANNsfrom 500 - 4000 Hz.

scholarly journals Risk Assessment of Recreational Noise–Induced Hearing Loss from Exposure through a Personal Audio System—iPod Touch

2019 ◽  
Vol 30 (07) ◽  
pp. 619-633 ◽  
Author(s):  
Kamakshi V. Gopal ◽  
Liana E. Mills ◽  
Bryce S. Phillips ◽  
Rajesh Nandy
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Risk Indicator ◽  
Noise Induced Hearing Loss ◽  
Ipod Touch ◽  
Distortion Product ◽  
Before And After ◽  
Within Subjects ◽  
Loud Music

AbstractRecreational noise–induced hearing loss (RNIHL) is a major health issue and presents a huge economic burden on society. Exposure to loud music is not considered hazardous in our society because music is thought to be a source of relaxation and entertainment. However, there is evidence that regardless of the sound source, frequent exposure to loud music, including through personal audio systems (PAS), can lead to hearing loss, tinnitus, difficulty processing speech, and increased susceptibility to age-related hearing loss.Several studies have documented temporary threshold shifts (TTS) (a risk indicator of future permanent impairment) in subjects that listen to loud music through their PAS. However, there is not enough information regarding volume settings that may be considered to be safe. As a primary step toward quantifying the risk of RNIHL through PAS, we assessed changes in auditory test measures before and after exposure to music through the popular iPod Touch device set at various volume levels.This project design incorporated aspects of both between- and within-subjects and used repeated measures to analyze individual groups.A total of 40 adults, aged 18–31 years with normal hearing were recruited and randomly distributed to four groups. Each group consisted of five males and five females.Subjects underwent two rounds of testing (pre- and postmusic exposure), with a 30-min interval, where they listened to a playlist consisting of popular songs through an iPod at 100%, 75%, 50%, or 0% volume (no music). Based on our analysis on the Knowles Electronic Manikin for Acoustic Research, with a standardized 711 coupler, it was determined that listening to the playlist for 30 min through standard earbuds resulted in an average level of 97.0 dBC at 100% volume, 83.3 dBC at 75% volume, and 65.6 dBC at 50% volume. Pure-tone thresholds from 500–8000 Hz, extended high-frequency pure tones between 9–12.5 kHz, and distortion product otoacoustic emissions (DPOAE) were obtained before and after the 30-min music exposure. Analysis of variance (ANOVA) was performed with two between-subjects factors (volume and gender) and one within-subjects factor (frequency). Change (shift) in auditory test measures was used as the outcome for the ANOVA.Results indicated significant worsening of pure-tone thresholds following music exposure only in the group that was exposed to 100% volume at the following frequencies: 2, 3, 4, 6 and 8 kHz. DPOAEs showed significant decrease at 2000 and 2822 Hz, also only for the 100% volume condition. No significant changes were found between pre- and postmusic exposure measures in groups exposed to 75%, 50%, or 0% volume conditions. Follow-up evaluations conducted a week later indicated that pure-tone thresholds had returned to the premusic exposure levels.These results provide quantifiable information regarding safe volume control settings on the iPod Touch with standard earbuds. Listening to music using the iPod Touch at 100% volume setting for as little as 30 min leads to TTS and worsening of otoacoustic emissions, a risk for permanent auditory damage.

scholarly journals Does Vincristine affect Cochlear function in children with acute lymphoblastic leukaemia?

2016 ◽  
Vol 27 (1) ◽  
pp. 3-7
Author(s):  
Suchetha Rao ◽  
Ranjith Kumar ◽  
Jayashree Bhat ◽  
Nutan Kamath
Keyword(s):  
High Frequency ◽  
Otoacoustic Emissions ◽  
Lymphoblastic Leukemia ◽  
Statistical Significance ◽  
Pure Tone Audiometry ◽  
Cochlear Function ◽  
Hearing Sensitivity ◽  
Distortion Product ◽  
High Frequency Audiometry

Context: Vincristine chemotherapy has dose dependent ototoxicity. Early detection of ototoxicity is better with otoacoustic emissions and high frequency audiometry than conventional pure tone audiometry. The study was done to see if vincristine treatment interferes with hearing sensitivity in children.Methods and Material: A prospective study was conducted on twenty-three children with acute lymphoblastic leukemia (ALL) on Multi Center Protocol (MCP 841).These were subjected to conventional audiometry, high frequency audiometry and distortion product otoacoustic emissions (DPOAEs) before starting chemotherapy. The follow up audiological evaluation after early intensive phase chemotherapy (approximately 6 months) was conducted in thirteen children, who received 12 doses of vincristine (1.4 mg/m2), cranial irradiation of 1800cGy (>3 years) as per protocol and antibiotics as per clinical demands.Results: Baseline audiological evaluation was normal. Follow-up evaluation DPOAEs showed a declining tendency, however changes did not reach statistical significance. Differences in median hearing thresholds prior and post treatment in higher frequency audiometry were also minimal which was not statistically significant. Conventional audiometric thresholds were not altered.Conclusions: The reduction in the signal noise ratio of DPOAE, and reduced hearing sensitivity in high frequencies in post chemotherapy in comparison with baseline measures cannot be ignored though it has failed to reach the level of statistical significance. children on vincristine should have a pre chemotherapy and follow up audiological evaluation with DPOAE The results of the present study needs to be strengthened by including larger sample and long term follow up.Bangladesh J Medicine Jan 2016; 27(1) : 3-7

Kanamycin Depletes Cochlear Polyamines in the Developing Rat

1994 ◽  
Vol 110 (1) ◽  
pp. 103-109 ◽  
Author(s):  
Charles M. Henley
Keyword(s):  
Otoacoustic Emissions ◽  
Outer Hair Cell ◽  
Organ Of Corti ◽  
Aminoglycoside Antibiotics ◽  
Basal Region ◽  
Cochlear Function ◽  
Polyamine Synthesis ◽  
Distortion Product ◽  
Functional Maturation ◽  
Developing Rat

Developing mammals are more sensitive to aminoglycoside antibiotics and other ototoxic agents than adults, with maximum sensitivity occurring during the period of anatomic and functional maturation of the cochlea. For the aminoglycoside antibiotics, the hypersensitive period in rats occurs during the second and third postnatal weeks. Toxicity is initially expressed as outer hair cell (OHC) damage in the high-frequency, basal region of the cochlea. Distortion-product otoacoustic emissions (DPOAEs), physiologic measures of OHC function, are particularly sensitive to aminoglycoside exposure during the period of rapid cochlear physiologic development. Toxicity is characterized by increased DPOAE thresholds and decreased amplitudes. The mechanism of developmental sensitivity to aminoglycosides is unknown. A potential biochemical target of aminoglycosides is the ornithine decarboxylase (ODC)-polyamine pathway. ODC activity is elevated in the developing rat cochlea, aminoglycosides inhibit cochlear ODC in developing rats, and α-difluoromethylornithine (a specific ODC inhibitor) impairs development of cochlear function. In the present study we demonstrate an incomplete polyamnine response to aminoglycoside damage, characterized by inhibition of the polyamines spermidine and spermine and accumulation of putrescine in the organ of Corti. Aminoglycoside inhibition of polyamine synthesis may mediate developmental ototoxic hypersensitivity by interfering with developmental and repair processes.

scholarly journals Effect of Caffeine on Otoacoustic Emissions

2021 ◽  
Author(s):  
Kumar Sanish Drepath ◽  
Athira Rajan ◽  
Srikanth Nayak ◽  
Arya Vijay ◽  
Sathish Kumar
Keyword(s):  
Otoacoustic Emissions ◽  
Signal To Noise Ratio ◽  
Large Population ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Caffeine Consumption ◽  
Coffee Intake ◽  
Distortion Product ◽  
Study Results ◽  
Before And After

Abstract Introduction Caffeine is consumed everyday in a variety of ways by a large population around the world, including coffee, tea, and soft drinks. Therefore, there is a significant need to explore the effects of caffeine on human auditory system. The present study aimed to investigate the effect of caffeine on cochlea using distortion product otoacoustic emission (DPOAE). Materials and Methods Thirty-three young adults were recruited for the study. The effect of caffeine on cochlea was assessed using DPOAE at frequencies between 1 to 10 kHz before and after caffeine consumption. Results The signal to noise ratio of DPOAE was compared before and after coffee intake, which revealed no significant differences. Conclusion The current study results suggest that caffeine has no effect on cochlear functioning.

Low vitamin B12 level and vitamin D level adversely affect on cochlear health in women

2020 ◽  
Vol 90 (3-4) ◽  
pp. 333-338
Author(s):  
Isil Karaer ◽  
Yahya Akalın
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Otoacoustic Emissions ◽  
Serum Vitamin ◽  
Vitamin B ◽  
Cochlear Function ◽  
Distortion Product ◽  
Vitamin D Levels ◽  
Study Participants ◽  
Low Serum

Abstract. The aim of this study is to examine the association between low serum vitamin B12 levels and low serum vitamin D levels and cochlear health in women. A prospective case–control study was carried out in the Department of Otolaryngology, Malatya Training and Research Hospital between 2017–2018. Thirty (30) patients with vitamin B12 deficiency (a mean age of 32.5 ± 1.7 years(y) women); 30 patients with vitamin D deficiency (a mean age of 32.3 ± 1.58 y women) and 30 controls (a mean age of 27.8 ± 1.48 y women) were recruited. The study participants have no evidence of symptomatic hearing loss. Transiently evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) of the study participants were recorded. A comparative analysis of the parameters revealed that results at TEOAE 1,2,3,4 kHz (p = 0.013, p = 0.002, p = 0.001, p = 0.001, respectively) and at DPOAE 1, 2, 6 kHz ( p < 0.001, p < 0.001, p = 0.002, respectively) were somewhat lower in patients with vitamin B12 deficient group when compared with the controls. Moreover, TEOAE 3,4 kHz (p = 0.005, p = 0.013 respectively) and DPOAE 1,2,6 kHz (p = 0.005, p = 0.01, p = 0.031, respectively) were lower in the vitamin D deficiency group compared with the controls. There was a significant association between both vitamin B12 deficiency and vitamin D deficiency and cochlear health. Patients with vitamin B12 and vitamin D deficiency should be evaluated for cochlear function.

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