Proliferation and Differentiation of Ependymal Cells after Transection of the Carp Spinal Cord

1997 ◽  
Vol 14 (2) ◽  
pp. 331-338 ◽  
Author(s):  
Hajime Yamada ◽  
Toshihiko Miyake ◽  
Tadahisa Kitamura
Keyword(s):  
Spinal Cord ◽  
Ependymal Cells ◽  
Proliferation And Differentiation

scholarly journals Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells

2006 ◽  
Vol 293 (2) ◽  
pp. 358-369 ◽  
Author(s):  
Noritaka Masahira ◽  
Hirohide Takebayashi ◽  
Katsuhiko Ono ◽  
Keisuke Watanabe ◽  
Lei Ding ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ependymal Cells ◽  
Embryonic Spinal Cord

scholarly journals Reaction of ependymal cells to spinal cord injury: a potential role for oncostatin pathway and microglial cells

2021 ◽  
Author(s):  
R. Chevreau ◽  
H Ghazale ◽  
C Ripoll ◽  
C Chalfouh ◽  
Q Delarue ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glial Cells ◽  
Mapk Signaling ◽  
Central Canal ◽  
Microglial Cells ◽  
Ependymal Cells ◽  
Rna Profiling ◽  
Cord Injury

AbstractEpendymal cells with stem cell properties reside in the adult spinal cord around the central canal. They rapidly activate and proliferate after spinal cord injury, constituting a source of new cells. They produce neurons and glial cells in lower vertebrates but they mainly generate glial cells in mammals. The mechanisms underlying their activation and their glial-biased differentiation in mammals remain ill-defined. This represents an obstacle to control these cells. We addressed this issue using RNA profiling of ependymal cells before and after injury. We found that these cells activate STAT3 and ERK/MAPK signaling during injury and downregulate cilia-associated genes and FOXJ1, a central transcription factor in ciliogenesis. Conversely, they upregulate 510 genes, six of them more than 20 fold, namely Crym, Ecm1, Ifi202b, Nupr1, Rbp1, Thbs2 and Osmr. OSMR is the receptor for the inflammatory cytokine oncostatin (OSM) and we studied its regulation and role using neurospheres derived from ependymal cells. We found that OSM induces strong OSMR and p-STAT3 expression together with proliferation reduction and astrocytic differentiation. Conversely, production of oligodendrocyte-lineage OLIG1+ cells was reduced. OSM is specifically expressed by microglial cells and was strongly upregulated after injury. We observed microglial cells apposed to ependymal cells in vivo and co-cultures experiments showed that these cells upregulate OSMR in neurosphere cells. Collectively, these results support the notion that microglial cells and OSMR/OSM pathway regulate ependymal cells in injury. In addition, the generated high throughput data provides a unique molecular resource to study how ependymal cell react to spinal cord lesion.

The distribution of non-synaptic intercellular junctions during neurone differentiation in the developing spinal cord of the clawed toad

Development ◽  
1975 ◽  
Vol 33 (2) ◽  
pp. 403-417
Author(s):  
Brian P. Hayes ◽  
Alan Roberts
Keyword(s):  
Spinal Cord ◽  
Gap Junctions ◽  
Neural Differentiation ◽  
Electrical Coupling ◽  
Intercellular Junctions ◽  
Ependymal Cells ◽  
Freedom Of Movement ◽  
Ventricular Cells ◽  
Vertebrate Embryos ◽  
Developing Spinal Cord

The distribution of intercellular junctions, other than synapses and their precursors, has beendescribed in the developing spinal cord of Xenopus laevis between the neurula andfree swimming tadpole stages. At the neurocoel, ventricular cells are joined in the apical contactzone by a sequence of junctions which usually has one or more intermediate junctions but often also includes close appositions, gap junctions and desmosomes. This apical complex is more diverse than that reported in other vertebrate embryos and between ependymal cells in the adult central nervous system. Gap junctions are also found between ventricular cells and their processes near the external cord surface. However, no other special junctions occur in this location under the basementlamella which surrounds the cord. Punctate intermediate junctions are generally distributed between undifferentiated and differentiating cells and their processes but were not found in neuropil after stage 28. These results are discussed in relation to cell movements during neural differentiation, possible effects on the freedom of movement of ions and molecules through extracellular pathways in the embryo, and possible intercytoplasmic pathways via gap junctions which may be responsible for the physiologically observed electrical coupling between neural tube cells.

Grafting of Choroid Plexus Ependymal Cells Promotes the Growth of Regenerating Axons in the Dorsal Funiculus of Rat Spinal Cord: A Preliminary Report

2001 ◽  
Vol 167 (2) ◽  
pp. 242-251 ◽  
Author(s):  
Chizuka Ide ◽  
Masaaki Kitada ◽  
Shushovan Chakrabortty ◽  
Masanori Taketomi ◽  
Naoya Matsumoto ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Choroid Plexus ◽  
Preliminary Report ◽  
Ependymal Cells ◽  
Rat Spinal Cord ◽  
Dorsal Funiculus

scholarly journals Normal sulfation levels regulate spinal cord neural precursor cell proliferation and differentiation

2012 ◽  
Vol 7 (1) ◽  
pp. 20 ◽  
Author(s):  
Michael Karus ◽  
Samira Samtleben ◽  
Claudia Busse ◽  
Teresa Tsai ◽  
Irmgard D Dietzel ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Proliferation ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation
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