Drug Interaction a Common Drug Therapy Problem in the Clinical Setup: Scenario of Khyber Pakhtunkhwa, Pakistan

2015 ◽  
Vol 5 ◽  
pp. 05
Author(s):  
Roheena Zafar ◽  
Iftikhar Ali
Keyword(s):  
Drug Interaction ◽  
Drug Therapy ◽  
Khyber Pakhtunkhwa ◽  
Common Drug ◽  
Drug Therapy Problem

scholarly journals Factors affecting general practitioners’ choice of drug therapy: A study in primary healthcare in Iceland

2021 ◽  
Vol 107 (11) ◽  
pp. 522-527
Author(s):  
Yrsa Ívarsdóttir ◽  
◽  
Jón Steinar Jónsson ◽  
Kristján Linnet ◽  
Anna Bryndís Blöndal ◽  
...  
Keyword(s):  
Primary Care ◽  
Decision Making ◽  
Drug Interaction ◽  
Drug Therapy ◽  
Primary Care Physicians ◽  
New Drugs ◽  
Factors Affecting ◽  
Face To Face ◽  
Software Information ◽  
Strongly Agree

Introduction: This study aimed to analyse several factors that influence the decision-making of primary care physicians in Iceland in their choice of drug therapy for their patients. Also, to find which factors can act as a hindrance in making the best choices. Finally, to analyse which elements could be most important in facilitating decisions. Material and methods: A questionnaire was sent by e-mail to physicians working in primary care in Iceland. The questionnaire comprised closed questions, open text boxes, and ranking questions. The data was processed and analysed using Microsoft Excel. Results: The total number of primary care physicians who responded to the questionnaire was 93, a response rate of 40.7% of all the primary care physicians. The results reveal that physicians working in primary care consider clinical guidelines, the Icelandic National Formulary, and personal experience to be the most important factors when choosing a medication. Primary care physicians strongly agree that the lack of drug interaction software connected to medical records is a shortcoming. The most important factors that need improvement to facilitate primary care physicians' decision-making are drug formularies and interaction software. Conclusion: The results suggest some factors that support physicians in primary care in making decisions when choosing drug therapy, such as a drug formulary, drug interaction software, information about patients’ drug therapy, variable length in face-to-face consultations, evidence based information on new drugs, and counselling provided by clinical pharmacists.

scholarly journals Successful Combination Therapy of Trazodone and Fluvoxamine for Pica in Alzheimer's Disease: A Case Report

2021 ◽  
Vol 12 ◽  
Author(s):  
Tadashi Kanamori ◽  
Yoshiyuki Kaneko ◽  
Kouju Yamada ◽  
Masahiro Suzuki
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Report ◽  
Drug Therapy ◽  
Combination Therapy ◽  
Frontotemporal Dementia ◽  
Late Stage ◽  
Daytime Sleepiness ◽  
Extrapyramidal Symptoms ◽  
Common Drug

Pica in Alzheimer's disease (AD) makes it difficult for caregivers to provide care. However, few effective medications have been reported for pica in AD. We report a case of AD with pica that was successfully improved by trazodone and fluvoxamine. An 80-year-old woman with AD was admitted to our hospital due to aggravated pica, including eating weeds in the facility's garden and eating a dishwashing sponge. Her pica was accompanied by oral tendency, prosopagnosia, and placidity. She took rivastigmine and memantine, but these were ineffective for her pica. She was given olanzapine and perospirone, but both were discontinued due to over-sedation and severe extrapyramidal symptoms, respectively. We then administered trazodone and fluvoxamine, both of which have demonstrated effectiveness for pica in frontotemporal dementia (FTD). Her pica behaviors then disappeared without daytime sleepiness. In this case, pica with oral tendency, which was accompanied by prosopagnosia and placidity, may be interpreted as a partial symptom of Klüver–Bucy syndrome (KBS). KBS is often seen in FTD, but also occurs in late-stage AD. Our case together with previous reports showing that trazodone and fluvoxamine were effective for pica in FTD suggest that the same common drug therapy may be successful in pica with oral tendency, regardless of the subtype of dementia.

scholarly journals Drug-Drug-Dietary interactions in pharmacotherapy of GIT medication: A review

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2903-2909
Author(s):  
Akula sowjanya ◽  
Abhisek Pal
Keyword(s):  
Drug Therapy ◽  
Drug Interactions ◽  
Food Consumption ◽  
Adverse Drug Reactions ◽  
Drug Effect ◽  
Google Scholar ◽  
Drug Reactions ◽  
Common Drug ◽  
Different Types ◽  
Dietary Interactions

Successful drug therapy depends on the interaction between drug-drug and drug-diet. Drug interactions are a vital reason for causing adverse drug reactions and modify one drug effect by another drug and these kinds of interactions can increase or decrease the effectiveness of the drug. Polypharmacy could be a major risk for Drug-Drug and Drug-food interactions. Food Consumption can alter the effect of drugs by interfering either with their pharmacokinetics or pharmacodynamics processes. Anti-ulcer drugs are used to treat different types of ulcer and that may interact with another drug showing undesirable effects. GIT medications interfere with another type of medication either with at the pharmacokinetic and pharmacodynamic level. The main objective of this article is to review data regarding common Drug-drug & Drug-food interactions related to GIT medications. Data was collected from Google Scholar, PubMed, and Scopus databases, and they were reviewed for publication on drug-drug & drug-food interactions related to GIT medications. This data is very helpful for pharmacists while reviewing and analyzing prescribed medication, especially in geriatrics prescriptions.

scholarly journals New tricks of prolyl oligopeptidase inhibitors – A common drug therapy for several neurodegenerative diseases

2019 ◽  
Vol 161 ◽  
pp. 113-120 ◽  
Author(s):  
Reinis Svarcbahs ◽  
Ulrika Julku ◽  
Tommi Kilpeläinen ◽  
Mirva Kyyrö ◽  
Maria Jäntti ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Neurodegenerative Diseases ◽  
Prolyl Oligopeptidase ◽  
Common Drug

Novel Coronavirus (COVID-19) Outbreak: Hope and Search for Effective Therapeutic Agent

2020 ◽  
Vol 17 (8) ◽  
pp. 940-942
Author(s):  
Saurabh Kumar
Keyword(s):  
Drug Therapy ◽  
Respiratory Diseases ◽  
Therapeutic Agent ◽  
Effective Therapy ◽  
High Rate ◽  
Major Threat ◽  
Common Drug ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

Background: Novel Coronavirus (COVID-19), respiratory diseases and a major threat to mankind is spreading at an unstoppable rate affecting almost every part of the world with Europe being the most affected continent. Originated from China in December 2019 with sequence homology similar to SARS having a high rate of mutation has created a global pandemic with no effective therapy available. Objective: This editorial summarizes the list of potential antiviral drugs or other effective therapy that is in the clinical trial. Methods: The literature search is based on recent publications (year, 2020) available on PubMed and drug/therapy registered on the ClinicalTrial.gov portal. Results: Hydroxychloroquine, tocilizumab, lopinavir/ritonavir, remdesivir, and convalescent plasma are some of the most common drug/therapy that has come as a hope against COVID-19. Conclusion: In view of the current COVID-19 situation, more rigorous efforts are needed. Drugs with better outcomes need more exploration.

Impact of Patient-Specific Drug Interaction Information on Physician Prescribing Patterns

1980 ◽  
Vol 14 (4) ◽  
pp. 280-283
Author(s):  
Thomas R. Adams ◽  
William J. Murray ◽  
J. Heyward Hull
Keyword(s):  
Drug Interaction ◽  
Drug Therapy ◽  
Drug Interactions ◽  
Prescribing Patterns ◽  
Study Patient ◽  
Patient Specific ◽  
Utilization Review ◽  
Control Groups ◽  
Anticoagulant Drug ◽  
Physician Prescribing

Patient exposure to potential anticoagulant drug interactions was identified by computerized drug-therapy surveillance, as part of a peer-review program. To evaluate the response of clinicians provided with data on the potential drug interactions, 119 “exposed” patients were randomly divided and assigned to study or control groups. Physicians prescribing for the 60 study patients were informed of the potential problem by letter and were furnished with information on the drug interaction, while the 59 control patients were only monitored. Physicians provided with the information made statistically more changes in drug therapy than those not informed ( p < 0.05). Over 75 percent of study-patient physicians responding to a questionnaire accompanying the drug interaction data indicated that the service was useful and should be expanded to other drugs. Application of methods similar to that used in this study should offer drug utilization review committees an effective approach to improving drug therapy.

scholarly journals Assessment of drug therapy problem and associated factors among adult hypertensive patients at Ayder comprehensive specialized hospital, Northern Ethiopia

2019 ◽  
Vol 19 (3) ◽  
pp. 2571-2579
Author(s):  
Asgedom Solomon Weldegebreal ◽  
Fekadu Tezeta ◽  
Atey Tesfay Mehari ◽  
Wubetu Gashaw ◽  
Kassa Tesfaye Dessale ◽  
...  
Keyword(s):  
Substance Use ◽  
Drug Therapy ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Northern Ethiopia ◽  
Antihypertensive Medications ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Drug Therapy Problem ◽  
Drug Therapy Problems

Background: Drug-therapy problems(DTPs) among hypertensive patients can result in patient’s morbidity and mortality. The main aim of this study was to assess drug therapy problem and associated factors among <="" span="" style="font-family: hypertensive patients.Methods: A hospital based cross sectional study was conducted. The data was collected from patients’ medical charts and through interview. Drug therapy problem was categorized according to Cipolle methods of DTP classification. Thedata was analyzed using the Statistical Package for the Social Sciences (SPSS), version 21.Results: A total of 241 patients were studied. The mean number of antihypertensive medications prescribed were 1.41±0.53. A total of 357 drug therapy problems(DTPs) were identified. From the patients studied,134(55.6%) had at least one evidence of drug therapy problem. Non adherence was the most commonly identified drug therapy problem occurred in (143(59.3%)) patients. Substance use (AOR=0.445, 95% CI= 0.227-0.870, p=0.018) and comorbidity (AOR= 2.099, 95% CI= 1.192-3.694, p=0.010) werethe predictors of DTP.Conclusion: More than half of the participants had evidence of onset drug therapy problem. Thus efforts that could boost antihypertensive compliance and minimizes substance use should be adopted to reduce patients’s drug therapy problems.Keywords: assessment, drug, therapy, problem, Ethiopia.

scholarly journals Analisis Hubungan Polifarmasi Dan Interaksi Obat Pada Pasien Rawat Jalan Yang Mendapat Obat Hipertensi Di Rsp. Dr. Ario Wirawan Periode Januari-Maret 2019

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Lamtiar Parulian Parulian ◽  
Ening Listyanti ◽  
Anita Kumala Hati ◽  
Istianatus Sunnah
Keyword(s):  
Drug Interaction ◽  
Drug Therapy ◽  
Drug Interactions ◽  
Related Problem ◽  
Current Treatment ◽  
Antihypertensive Drug Therapy ◽  
Drug Related Problems ◽  
Inclusion Criteria ◽  
Drug Related Problem ◽  
Spearman Test

Hipertensi merupakan masalah kesehatan masyarakat yang umum di negara berkembang. Riskesdas tahun 2013 menyatakan bahwa prevalensi hipertensi secara  umum diindonesia sebesar 26,5% dengan proporsi  serbesar berada di Jawa Tengah yaitu 57,89%. Polifarmasi secara signifikan bisa meningkatkan resiko interaksi obat dimana interaksi obat merupakan salah satu faktor penting dalam drug related problem yang dapat mempengaruhi outcome terapi pasien. Interaksi obat merupakan satu dari delapan kategori masalah terkait obat (drug-related problem) yang dapat mempengaruhi outcome klinis pasien, dengan meningkatnya kompleksitas obat-obat yang digunakan dalam pengobatan saat ini dan kecenderungan terjadinya praktik polifarmasi, maka kemungkinan terjadinya interaksi obat semakin besar. Tujuan dari penelitian ini adalah untuk mengetahui hubungan interaksi obat dalam resep polifarmasi pada pasien yang mendapat terapi obat antihipertensi di instalasi farmasi RSP dr. Ario Wirawan Salatiga. Penelitian ini dilakukan secara retrospektif dengan menggunakan  resep pasien hipertensi rawat jalan di Rumah Sakit Paru Ario Wirawan Salatiga periode Januari-Maret 2019  sebanyak 72 sampel yang termasuk ke dalam kriteria inklusi. Data dianalisis secara deskriptif menggunakan Drug Interaction Facts dan di analisis dengan Spearman test. Diperoleh data bahwa jumlah interaksi obat-obat yang terjadi (51,39%). Pola mekanisme yang terbanyak adalah farmakokinetik (53,97%) dengan tingkat keparahan yang terbanyak adalah minor (42,86%). Hasil menunjukkan adanya korelasi antara jumlah obat dengan kejadian interaksi (r=0,986, p=000) adanya hubungan yang sangat signifikan.Kata kunci : Interaksi Obat, polifarmasi, terapi obat hipertensi.Hypertension is a common problem in developing countries. Based on the basic health research  in 2013, the prevalence of hypertension in Indonesia was 26.5% with a large proportion in Central Java at 57.89%. Polypharmacy can significantly increase the risk of drug interactions where drug interactions are an important factor in drug related problems that can affect the outcome of patient therapy. Drug interaction is one of eight categories of drug-related problems that can affect a patient's clinical outcome. Increasing complexity of the drugs used in current treatment will raise the tendency for polypharmacy to occur, resulting higher chance for the drug interaction possibility.This study is aimed to find relationship of drug interactions with polypharmacy prescriptions by patients receiving antihypertensive drug therapy in Dr. Ario Wirawan Hospital. This study was conducted retrospectively using the outpatient prescription that entered the inclusion criteria at Dr. Ario Wirawan Hospital Salatiga. A total of 72 samples that included in the inclusion criteria. Data were analyzed descriptively using Drug Interaction Facts and analyzed by Spearman test. Result showed that the number of drug interactions that occurred (51,39%). The most mechanism pattern of the drug interaction was pharmacokinetics (53,97%) with the highest severity level being minor (42,86%). This study showed that there is a a very significant correlation between the number of drugs and interactions (r = 0.986, p = 000).Keywords : Drug interactions, polypharmacy, hypertension drug therapy  

scholarly journals A STUDY DESCRIBING THE USAGE PATTERN OF ANTIMICROBIALS WITH INSIGHTS INTO ANTIMICROBIAL DRUG-DRUG INTERACTIONS AMONG ADULT POPULATION IN HOSPITAL SETTINGS

2021 ◽  
pp. 68-70
Author(s):  
Tabassum Fathima ◽  
Prukruthi R ◽  
Manikandan A ◽  
Muhammed Ramees P K ◽  
Leena Pavitha P
Keyword(s):  
Drug Interaction ◽  
Retrospective Study ◽  
Drug Interactions ◽  
Antimicrobial Therapy ◽  
Adult Population ◽  
Antimicrobial Drug ◽  
Adult Patients ◽  
Usage Pattern ◽  
Common Drug ◽  
Drug Drug Interaction

The study aims to describe the use of antimicrobials among adult population in hospital settings with emphasis on the antimicrobial therapy provided and potential antimicrobial drug-drug interactions identified. 108 adult patients who were prescribed antimicrobials were considered for this retrospective study which was carried out over a period of 3 months. It was identified that antimicrobials prescribed were largely antibacterial (91.2%) with Piperacillin + Tazobactam (24 times) and Cefuroxime (15 times) being the most commonly prescribed antimicrobials on treatment and discharge, respectively. Upon assessing the antimicrobial therapy, it was identified that antimicrobials were predominantly prescribed empirically (57.4%) and monotherapy was observed more, both on treatment (52.8%) and discharge (47.2%). A total of 79 different potential antimicrobial drug-drug interactions were identified, out of which, 64.6% were major interactions. Ciprofloxacin + Metronidazole drug-drug interaction was the most common drug interaction observed 6 times, whereas clarithromycin and ciprofloxacin caused the greatest number of interactions with a frequency of 10 instances each. Ondansetron was the non-antimicrobial drug that caused the greatest number of drug interactions (21.2%). The present study reinforces that antibiotics and other antimicrobials are a group of very commonly prescribed medications in the hospital with a variety of indications. An important, but often unheeded aspect of therapy is antimicrobial interactions with other drugs, which this study has highlighted.

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