Intraosseous Injection of rhBMP-2/Calcium Phosphate Matrix Improves Bone Structure and Strength in the Proximal Aspect of the Femur in Chronic Ovariectomized Nonhuman Primates

2013 ◽  
Vol 95 (1) ◽  
pp. 36-47 ◽  
Author(s):  
Howard J Seeherman ◽  
X Jian Li ◽  
Erica Smith ◽  
Jascha Parkington ◽  
Rebecca Li ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Nonhuman Primates ◽  
Bone Structure ◽  
Intraosseous Injection

scholarly journals Simulation of cortico-cancellous bone structure by 3D printing of bilayer calcium phosphate-based scaffolds

Bioprinting ◽  
2017 ◽  
Vol 6 ◽  
pp. 1-7 ◽  
Author(s):  
Thafar Almela ◽  
Ian M. Brook ◽  
Kimia Khoshroo ◽  
Morteza Rasoulianboroujeni ◽  
Farahnaz Fahimipour ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
3D Printing ◽  
Cancellous Bone ◽  
Bone Structure ◽  
Cancellous Bone Structure

Process and Fabrication of Calcium Triphosphate and Hydroxylapatite Microspheres for Clinical Application

2006 ◽  
Vol 49 ◽  
pp. 14-20
Author(s):  
Egbert Brandau ◽  
Thorsten Brandau
Keyword(s):  
Calcium Phosphate ◽  
Size Distribution ◽  
Clinical Application ◽  
Bone Structure ◽  
Clinical Applications ◽  
Narrow Size Distribution ◽  
Phosphate Compounds

Clinical applications of Calcium phosphate compounds are done in most cases with powders of Calcium-tri-phosphate and/or Hydroxylapatite to enhance the surgery of orthopaedic repair. The application of microspheres of these compounds has big advantages to faster surgery and higher strength of the bone structure. The special processes to produce microspheres of narrow size distribution and high sphericity out Calcium-tri-phosphate and Hydroxylapatite are described. Properties and composition of these microspheres as calcined and as sintered are given.

Basic Properties of Novel Bioactive Cement Based on Silica-Calcium Phosphate Composite and Carbonate Apatite

2016 ◽  
Vol 720 ◽  
pp. 147-152 ◽  
Author(s):  
Myrna Nurlatifah Zakaria ◽  
Arief Cahyanto ◽  
Ahmed El-Ghannam
Keyword(s):  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Bone Structure ◽  
Control Group ◽  
Apatite Formation ◽  
Carbonate Apatite ◽  
The Novel ◽  
Pulp Tissue ◽  
Group 3 ◽  
Group 2

Silica-calcium phosphate composite (SCPC) and carbonate apatite (CO3Ap) are resorbable bioactive materials with the ability to adapt to bone structure and to induce bone regeneration. Considering the similarity between bone and dental structure, where both are mainly composed of calcium deficient carbonate containing hydroxyapatite, we hypothesize that a SCPC-CO3Ap bone cement might also be favorable for the regeneration of dentin and pulp tissue. Therefore, in the present study we report on the effect of composition and structure of SCPC-CO3Ap cement on the morphology, setting and mechanical properties of the material. The novel bioceramics cement composed of vaterite, dicalcium phosphate anhydrous (DCPA) and SCPC. The powder cement ratio divided into 5 groups: group 1 (60% DCPA : 40% vaterite : 0% SCPC) as a control, group 2 (60% DCPA : 10% vaterite : 30% SCPC), group 3 (60% DCPA : 20% vaterite : 20% SCPC), group 4 (60% DCPA : 30% vaterite : 10% SCPC), and group 5 (60% DCPA : 0% vaterite : 40% SCPC). Each group was mixed by 1M Na2HPO4 aqueous solution at liquid to powder ratio of 0.5 and hardened at 37°C and 100 % of relative humidity for 72 hours. Set cement was examined by X-Ray diffraction (XRD), scanning electron microscopy (SEM) and the mechanical strength was evaluated by diametral tensile strength. XRD patterns revealed that the apatite formation was formed after 72 hours, however the intensity of apatite varied based on the SCPC content. The DTS evaluation indicated that group 3 has the highest mechanical strength compared to others. This was supported by SEM analysis of set cement showing more compact surface microstructure of group 2 and 3 compared to other different ratio and control group. The novel bioceramics cement was successfully made using vaterite, DCPA and SCPC. This new cement is currently being investigated for dental application to induce dentinogenesis.

Characterization of Three Calcium Phosphate Microporous Granulated Bioceramics

2014 ◽  
Vol 936 ◽  
pp. 687-694 ◽  
Author(s):  
Nelson H.A. Camargo ◽  
Priscila F. Franczak ◽  
Enori Gemelli ◽  
Bruna Ditzel da Costa ◽  
Aury Nunes de Moraes
Keyword(s):  
Controlled Release ◽  
Calcium Phosphate ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Bone Structure ◽  
Calcium Phosphates ◽  
Morphological Characteristics ◽  
Biological Environment

The calcium phosphate microporous bioceramics, and hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) biphasic compositions, in the granular form of microporous biomaterials, are research themes and present potential biomedical applications in rebuilding and repairing maxillofacial bone and tooth structure and in orthopedic applications. This is associated with microstructural characteristics of biocompatibility and bioactivity and osteoconductivity properties that these biomaterials offer when appliedin vivoor in simulated environment. Another differential point of these biomaterials is the solubilization capacity that they present when applied in the biological environment. These compositions of calcium phosphates (hydroxyapatite matrix and/or β-tricalcium phosphate) allow for the gradual release of calcium and phosphate ions for the biological environment, which are absorbed and promote the formation of new bone tissue. These materials are also promising in applications in the field of traumatology as in the repair of traumatized bone tissue and drugs controlled release and bone structure treatments. The favorable results of these biomaterials as bone reconstruction matrix and drugs controlled release are associated with crystallographic characteristics, morphology, surface and solubility that these biomaterials present when in contact with body fluids. This work aimed to describe three types of calcium phosphate microporous granulated biomaterials. The biomaterials used were provided by the Biomaterials Group from Universidade do Estado de Santa Catarina - UDESC and are: hydroxyapatite, β-tricalcium phosphate and biphasic composition 60% hydroxyapatite/40% β-tricalcium phosphate. The Scanning Electron Microscopy technique (SEM) was used for carrying out the morphological characterization and microstructure studies of granulated biomaterials. The X-Ray Diffractometry (XRD) served for characterization of crystalline phases. Arthur Method was used for determining open porosity and hydrostatic density of biomaterials. The BET technique served to support determination of the surface area of microporous granulated biomaterials. The results are encouraging and show that these biomaterials present promising morphological characteristics and microporous microstructure as wettability and capillarity. These characteristics may contribute to biomaterial osteointegration by new tissue, bone formation and mineralization process.

Objective Quantification of Porous Structure in Orthopaedic Biomaterial Implants Using Micro Computed Tomography

2007 ◽  
Vol 334-335 ◽  
pp. 1205-1208
Author(s):  
H.Y. Yeung ◽  
Ling Qin ◽  
K.M. Lee ◽  
K.S. Leung ◽  
Jack C.Y. Cheng
Keyword(s):  
Computed Tomography ◽  
Calcium Phosphate ◽  
Porous Structure ◽  
Bone Structure ◽  
Water Immersion ◽  
Three Dimensional ◽  
Micro Computed Tomography ◽  
Immersion Method ◽  
Calcium Phosphate Ceramics ◽  
Porous Bioceramic

Porous calcium phosphate ceramics have been widely investigated in orthopaedic surgery as bone extensor. Attention has been given to manufacturing of a porous bioceramic that mimics the trabecular bone structure for proper bone regeneration and integration. Although different methods have been applied to manufacture the porous structure, it was unable to visualize the pores and their interconnections within the ceramic and had objective measurement of the calcium phosphate ceramics. With the advance of biomedical imaging through micro-computed tomography (microCT), the study attempted to quantify the pore structure of different calcium phosphate ceramics. Three kinds of bioceramic blocks, namely BSC, ChronOS, and THA, were synthesized by three methods and tested in the study. Six blocks of each bioceramic were evaluated by conventional water immersion method and microCT. The pore size and connectivity of the pores were evaluated with standardized protocols. The three-dimensional analysis of the pores and their distribution by microCT was presented. The ChronOS had more functional pores (200-400μm in diameter) than the BSC and THA did (p<0.05). Providing objective information on the functional pores, the microCT evaluation serves as a good standard for specification of the bioceramic-related implants.

scholarly journals Synthesis and in vitro Experiment of Biomaterial Tricalcium Phosphate

2016 ◽  
Vol 33 (2) ◽  
pp. 78
Author(s):  
X.V Bui
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Bone Structure ◽  
Chemical Properties ◽  
Synthetic Material ◽  
Physico Chemical ◽  
Ft Ir ◽  
Hard Tissue Engineering

Calcium phosphate ceramics consist of materials such as hydroxyapatite, tricalcium phosphate (TCP), calcium phosphate cement (CPC), biphasic calcium phosphate, etc. CPCs have been used for filling bone defects in dentistry and orthopedics. Among these materials, β-tricalcium phosphate is suggestedas an ideal candidate for bone graft in hard tissue engineering due to its high biocompatibility, bioactivity and bone bonding. The preparation, as well as the application of this powder material, has been the important topic of research in material science. In this paper, β-tricalcium phosphate (β-TCP), a component that has chemical formulation similar to bone structure, was synthesized by the precipitate method and then calcinated at 1000oC for 5 h. The physico-chemical properties of synthetic material were examined by XRD, FT-IR and SEM methods. In vitro experience was also carried by soaking β-TCP simulated body fluid powder in a different period of time. Obtained results confirmed the quality of β-TCP synthetic material and its bioactivity.

Synthesis and Characterization of Calcium Phosphate from Fossilized Calcareous Shells for Biomedical Applications

2014 ◽  
Vol 798-799 ◽  
pp. 449-453
Author(s):  
Daiara F. Silva ◽  
Nelson Heriberto Almeida Camargo ◽  
Gisele M.L. Dalmônico ◽  
Pricyla Corrêa ◽  
Mônica S. Schneider ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Tissue ◽  
Biomedical Applications ◽  
Bone Structure ◽  
Raw Materials ◽  
New Class ◽  
Innovative Biomaterials ◽  
Near Future

Calcium phosphate nanostructured biomaterials are a new class of biomaterials, they are clinically promising for bone tissue reconstitution. That is because this new class of biomaterials provides new microstructural features, nanostructural, surface area and micropore grains of different conventional biomaterials capable of offering new expectations in the bone tissue reconstitution and formation process [1, 2, 3, 4, 5]. Studies performed in vivo by different authors indicate these bioceramics as innovative biomaterials and may, in the near future, present themselves as biomaterials which can replace conventional biomaterials autogenous, alogenous and exogenous treatments on bone structure of the human skeleton. The calcium phosphate compositions produced from natural raw materials also have being promising for biomedical applications for these new biomaterials that have physical morphology and biological characteristics very similar to the bone tissue [4, 5, 6].

Bone Structure Explains Racial Variance in Fractures

2006 ◽  
Vol 5 (12) ◽  
pp. 30
Author(s):  
KERRI WACHTER
Keyword(s):  
Bone Structure
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