scholarly journals Effects of Mechanical Loading on Intervertebral Disc Metabolism In Vivo

2006 ◽  
Vol 88 (suppl_2) ◽  
pp. 41 ◽  
Author(s):  
James C. Iatridis
Keyword(s):  
Intervertebral Disc ◽  
Mechanical Loading

scholarly journals Region-Dependent Aggrecan Degradation Patterns in the Rat Intervertebral Disc Are Affected by Mechanical Loading In Vivo

Spine ◽  
2011 ◽  
Vol 36 (3) ◽  
pp. 203-209 ◽  
Author(s):  
James C. latridis ◽  
Karolyn Godburn ◽  
Karin Wuertz ◽  
Mauro Alini ◽  
Peter J. Roughley
Keyword(s):  
Intervertebral Disc ◽  
Mechanical Loading

scholarly journals EFFECTS OF MECHANICAL LOADING ON INTERVERTEBRAL DISC METABOLISM IN VIVO

2006 ◽  
Vol 88 ◽  
pp. 41-46 ◽  
Author(s):  
JAMES C. IATRIDIS ◽  
JEFFREY J. MACLEAN ◽  
PETER J. ROUGHLEY ◽  
MAURO ALINI
Keyword(s):  
Intervertebral Disc ◽  
Mechanical Loading

The effect of static in vivo bending on the murine intervertebral disc

2001 ◽  
Vol 1 (4) ◽  
pp. 239-245 ◽  
Author(s):  
Charles Court ◽  
Olivier K Colliou ◽  
Jennie R Chin ◽  
Ellen Liebenberg ◽  
David S Bradford ◽  
...  
Keyword(s):  
Intervertebral Disc

scholarly journals An in vivo study of the effect of c-Jun on intervertebral disc degeneration in rats

Bioengineered ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 4320-4330
Author(s):  
Ming Lei ◽  
Kangcheng Zhao ◽  
Wenbin Hua ◽  
Kun Wang ◽  
Shuai Li ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
In Vivo Study

Effects of shear force on intervertebral disc: an in vivo rabbit study

2015 ◽  
Vol 24 (8) ◽  
pp. 1711-1719 ◽  
Author(s):  
Dong-Dong Xia ◽  
Sheng-Lei Lin ◽  
Xiang-Yang Wang ◽  
Yong-Li Wang ◽  
Hong-Ming Xu ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Shear Force

scholarly journals In vivo intervertebral disc deformation: intratissue strain patterns within adjacent discs during flexion–extension

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Robert L. Wilson ◽  
Leah Bowen ◽  
Woong Kim ◽  
Luyao Cai ◽  
Stephanie Ellyse Schneider ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Biomechanical Analysis ◽  
Resonance Imaging ◽  
Tissue Architecture ◽  
Mechanical Responses ◽  
Flexion Extension ◽  
Adjacent Disc ◽  
Shear Strains ◽  
Magnetic Resonance Imaging Mri

AbstractThe biomechanical function of the intervertebral disc (IVD) is a critical indicator of tissue health and pathology. The mechanical responses (displacements, strain) of the IVD to physiologic movement can be spatially complex and depend on tissue architecture, consisting of distinct compositional regions and integrity; however, IVD biomechanics are predominately uncharacterized in vivo. Here, we measured voxel-level displacement and strain patterns in adjacent IVDs in vivo by coupling magnetic resonance imaging (MRI) with cyclic motion of the cervical spine. Across adjacent disc segments, cervical flexion–extension of 10° resulted in first principal and maximum shear strains approaching 10%. Intratissue spatial analysis of the cervical IVDs, not possible with conventional techniques, revealed elevated maximum shear strains located in the posterior disc (nucleus pulposus) regions. IVD structure, based on relaxometric patterns of T2 and T1ρ images, did not correlate spatially with functional metrics of strain. Our approach enables a comprehensive IVD biomechanical analysis of voxel-level, intratissue strain patterns in adjacent discs in vivo, which are largely independent of MRI relaxometry. The spatial mapping of IVD biomechanics in vivo provides a functional assessment of adjacent IVDs in subjects, and provides foundational biomarkers for elastography, differentiation of disease state, and evaluation of treatment efficacy.

scholarly journals Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm

2021 ◽  
Author(s):  
Sheng-Long Ding ◽  
Tai-Wei Zhang ◽  
Qi-Chen Zhang ◽  
Wang Ding ◽  
Ze-Fang Li ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Intervertebral Disc ◽  
Mechanical Loading ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Night Shift ◽  
Mechanical Strain ◽  
Inhibitory Effect ◽  
Shift Workers ◽  
Normal Environment

AbstractNight shift workers with disordered rhythmic mechanical loading are more prone to intervertebral disc degeneration (IDD). Our results showed that circadian rhythm (CR) was dampened in degenerated and aged NP cells. Long-term environmental CR disruption promoted IDD in rats. Excessive mechanical strain disrupted the CR and inhibited the expression of core clock proteins. The inhibitory effect of mechanical loading on the expression of extracellular matrix genes could be reversed by BMAL1 overexpression in NP cells. The Rho/ROCK pathway was demonstrated to mediate the effect of mechanical stimulation on CR. Prolonged mechanical loading for 12 months affected intrinsic CR genes and induced IDD in a model of upright posture in a normal environment. Unexpectedly, mechanical loading further accelerated the IDD in an Light-Dark (LD) cycle-disrupted environment. These results indicated that intrinsic CR disruption might be a mechanism involved in overloading-induced IDD and a potential drug target for night shift workers.

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