Antibiotic-Loaded Bone Cement for Infection Prophylaxis in Total Joint Replacement

2006 ◽  
Vol 88 (11) ◽  
pp. 2487-2500 ◽  
Author(s):  
William A. Jiranek ◽  
Arlen D. Hanssen ◽  
A. Seth Greenwald
Keyword(s):  
Bone Cement ◽  
Joint Replacement ◽  
Total Joint Replacement ◽  
Infection Prophylaxis

scholarly journals Antibiotic-loaded Bone Cement as Prophylaxis in Total Joint Replacement

2017 ◽  
Vol 9 (4) ◽  
pp. 331-341 ◽  
Author(s):  
Javier Martínez-Moreno ◽  
Virginia Merino ◽  
Amparo Nácher ◽  
José Luis Rodrigo ◽  
Mónica Climente ◽  
...  
Keyword(s):  
Bone Cement ◽  
Joint Replacement ◽  
Total Joint Replacement

Improvement of the Bonding between Metal Implant and Bone Cement in Total Joint Replacement

2005 ◽  
pp. 36-40
Author(s):  
Horst Fischer ◽  
Dieter Christian Wirtz ◽  
Ahmet Emin Özgören ◽  
Karl Walter Zilkens ◽  
Fritz Uwe Niethard ◽  
...  
Keyword(s):  
Bone Cement ◽  
Joint Replacement ◽  
Total Joint Replacement ◽  
Metal Implant

scholarly journals Influence of Antibiotic-Loaded Acrylic Bone Cement Composition on Drug Release Behavior and Mechanism

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2240
Author(s):  
I-Cheng Chen ◽  
Chen-Ying Su ◽  
Wei-Han Nien ◽  
Tzu-Tien Huang ◽  
Chang-Hung Huang ◽  
...  
Keyword(s):  
Infection Control ◽  
Bone Cement ◽  
Joint Replacement ◽  
Total Joint Replacement ◽  
Joint Infection ◽  
Acrylic Bone Cement ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Antibiotic Release

Periprosthetic joint infection (PJI) is a devastating complication after total joint replacement with considerable morbidity and large economic burdens. Antibiotic-Loaded Bone Cement (ALBC) has been developed as a valuable tool for local administration and is becoming one of the most effective methods for the prevention and treatment of orthopedic infections. Controlling antibiotic release from ALBC is critical to achieve effective infection control, however, the antibiotic elution rates are generally low, and the mechanisms are poorly understood. Thus, the present study aims to investigate the effects of the basic acrylic bone cement components, including liquid/powder (monomer-to-polymer) ratios, radiopacifier, initiator, and doses of antibiotics on the porosity, antibiotic elution rates and mechanical properties of polymethylmethacrylate (PMMA) based ALBC. The obtained results from the in vitro studies suggested that a reduction in the liquid/powder ratio and an increase in the radiopacifier ratio and gentamicin doses led to increased porosity and release of antibiotic, while the initiator ratio exerted no effect on elution rates. In conclusion, we hope that by varying the composition of ALBC, we could considerably enhance the antibiotic elution rates by increasing porosity, while maintaining an adequate mechanical strength of the bone cements. This finding might provide insights into controlling antibiotic release from ALBC to achieve effective infection control after total joint replacement surgery.

Sign in / Sign up

Export Citation Format

Share Document