Safety and Efficacy of Ultraviolet-A Light-Activated Gene Transduction for Gene Therapy of Articular Cartilage Defects

2006 ◽  
Vol 88 (4) ◽  
pp. 753-761 ◽  
Author(s):  
M. D. Maloney ◽  
J. J. Goater ◽  
R. Parsons ◽  
H. Ito ◽  
R. J. O'Keefe ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Articular Cartilage ◽  
Cartilage Defects ◽  
Gene Transduction ◽  
Ultraviolet A ◽  
Safety And Efficacy ◽  
Articular Cartilage Defects

SAFETY AND EFFICACY OF ULTRAVIOLET-A LIGHT-ACTIVATED GENE TRANSDUCTION FOR GENE THERAPY OF ARTICULAR CARTILAGE DEFECTS

2006 ◽  
Vol 88 (4) ◽  
pp. 753-761 ◽  
Author(s):  
MICHAEL D. MALONEY ◽  
J. JEFFREY GOATER ◽  
RICHARD PARSONS ◽  
HIROMU ITO ◽  
REGIS J. OʼKEEFE ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Articular Cartilage ◽  
Cartilage Defects ◽  
Gene Transduction ◽  
Ultraviolet A ◽  
Safety And Efficacy ◽  
Articular Cartilage Defects

scholarly journals A composite scaffold of Wharton’s jelly and chondroitin sulphate loaded with human umbilical cord mesenchymal stem cells repairs articular cartilage defects in rat knee

2021 ◽  
Vol 32 (4) ◽  
Author(s):  
Zhong Li ◽  
Yikang Bi ◽  
Qi Wu ◽  
Chao Chen ◽  
Lu Zhou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Composite Scaffold ◽  
Biomechanical Properties ◽  
Cartilage Defects ◽  
Human Umbilical Cord ◽  
Composite Scaffolds ◽  
Articular Cartilage Defects

AbstractTo evaluate the performance of a composite scaffold of Wharton’s jelly (WJ) and chondroitin sulfate (CS) and the effect of the composite scaffold loaded with human umbilical cord mesenchymal stem cells (hUCMSCs) in repairing articular cartilage defects, two experiments were carried out. The in vitro experiments involved identification of the hUCMSCs, construction of the biomimetic composite scaffolds by the physical and chemical crosslinking of WJ and CS, and testing of the biomechanical properties of both the composite scaffold and the WJ scaffold. In the in vivo experiments, composite scaffolds loaded with hUCMSCs and WJ scaffolds loaded with hUCMSCs were applied to repair articular cartilage defects in the rat knee. Moreover, their repair effects were evaluated by the unaided eye, histological observations, and the immunogenicity of scaffolds and hUCMSCs. We found that in vitro, the Young’s modulus of the composite scaffold (WJ-CS) was higher than that of the WJ scaffold. In vivo, the composite scaffold loaded with hUCMSCs repaired rat cartilage defects better than did the WJ scaffold loaded with hUCMSCs. Both the scaffold and hUCMSCs showed low immunogenicity. These results demonstrate that the in vitro construction of a human-derived WJ-CS composite scaffold enhances the biomechanical properties of WJ and that the repair of knee cartilage defects in rats is better with the composite scaffold than with the single WJ scaffold if the scaffold is loaded with hUCMSCs.

Comparative Study of the Reconstruction of Articular Cartilage Defects with Free Costal Perichondrial Grafts and Free Tibial Periosteal Grafts: An Experimental Study on Rabbits

1999 ◽  
Vol 65 (5) ◽  
pp. 402-407 ◽  
Author(s):  
A. Carranza-Bencano ◽  
M. Perez-Tinao ◽  
P. Ballesteros-Vazquez ◽  
J. R. Armas-Padron ◽  
A. Hevia-Alonso ◽  
...  
Keyword(s):  
Experimental Study ◽  
Articular Cartilage ◽  
Comparative Study ◽  
Cartilage Defects ◽  
Articular Cartilage Defects

Articular cartilage defects: detectability in cadaver knees with MR

1987 ◽  
Vol 148 (6) ◽  
pp. 1153-1157 ◽  
Author(s):  
VM Gylys-Morin ◽  
PC Hajek ◽  
DJ Sartoris ◽  
D Resnick
Keyword(s):  
Articular Cartilage ◽  
Cartilage Defects ◽  
Articular Cartilage Defects
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