Osteogenic Effects of Traumatic Brain Injury on Experimental Fracture-Healing

2006 ◽  
Vol 88 (4) ◽  
pp. 738-743 ◽  
Author(s):  
M. Boes ◽  
M. Kain ◽  
S. Kakar ◽  
F. Nicholls ◽  
D. Cullinane ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Fracture Healing ◽  
Experimental Fracture ◽  
Experimental Fracture Healing

OSTEOGENIC EFFECTS OF TRAUMATIC BRAIN INJURY ON EXPERIMENTAL FRACTURE-HEALING

2006 ◽  
Vol 88 (4) ◽  
pp. 738-743 ◽  
Author(s):  
MATTHEW BOES ◽  
MICHAEL KAIN ◽  
SANJEEV KAKAR ◽  
FRED NICHOLLS ◽  
DENNIS CULLINANE ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Fracture Healing ◽  
Experimental Fracture ◽  
Experimental Fracture Healing

Experimental Fracture Healing Studies

1988 ◽  
Vol 2 (1) ◽  
pp. 68-69
Author(s):  
D. G. Lewallen ◽  
H. T. Aro ◽  
E. Y. S. Chao ◽  
T. H. Berquest ◽  
P. J. Kelly
Keyword(s):  
Fracture Healing ◽  
Experimental Fracture ◽  
Experimental Fracture Healing

Levofloxacin and Trovafloxacin Inhibition of Experimental Fracture-Healing

2003 ◽  
Vol 414 ◽  
pp. 95-100 ◽  
Author(s):  
Archie C. Perry ◽  
Branko Prpa ◽  
Mark S. Rouse ◽  
Kerryl E. Piper ◽  
Arlen D. Hanssen ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Experimental Fracture ◽  
Experimental Fracture Healing

The Association Between Traumatic Brain Injury and Accelerated Fracture Healing: A Study on the Effects of Growth Factors and Cytokines

2020 ◽  
Vol 71 (1) ◽  
pp. 162-168
Author(s):  
Majid Mollahosseini ◽  
Hadis Ahmadirad ◽  
Reza Goujani ◽  
Hossein Khorramdelazad
Keyword(s):  
Traumatic Brain Injury ◽  
Growth Factors ◽  
Brain Injury ◽  
Fracture Healing

scholarly journals Leptin Mediated Pathways Stabilize Posttraumatic Insulin and Osteocalcin Patterns after Long Bone Fracture and Concomitant Traumatic Brain Injury and Thus Influence Fracture Healing in a Combined Murine Trauma Model

2020 ◽  
Vol 21 (23) ◽  
pp. 9144
Author(s):  
Anja Garbe ◽  
Frank Graef ◽  
Jessika Appelt ◽  
Katharina Schmidt-Bleek ◽  
Denise Jahn ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Fracture Healing ◽  
Bone Fracture ◽  
Long Bone ◽  
Mouse Strains ◽  
Leptin Deficiency ◽  
Long Bone Fracture ◽  
Trauma Model ◽  
Deficient Mice

Recent studies on insulin, leptin, osteocalcin (OCN), and bone remodeling have evoked interest in the interdependence of bone formation and energy household. Accordingly, this study attempts to investigate trauma specific hormone changes in a murine trauma model and its influence on fracture healing. Thereunto 120 female wild type (WT) and leptin-deficient mice underwent either long bone fracture (Fx), traumatic brain injury (TBI), combined trauma (Combined), or neither of it and therefore served as controls (C). Blood samples were taken weekly after trauma and analyzed for insulin and OCN concentrations. Here, WT-mice with Fx and, moreover, with combined trauma showed a greater change in posttraumatic insulin and OCN levels than mice with TBI alone. In the case of leptin-deficiency, insulin changes were still increased after bony lesion, but the posttraumatic OCN was no longer trauma specific. Four weeks after trauma, hormone levels recovered to normal/basal line level in both mouse strains. Thus, WT- and leptin-deficient mice show a trauma specific hyperinsulinaemic stress reaction leading to a reduction in OCN synthesis and release. In WT-mice, this causes a disinhibition and acceleration of fracture healing after combined trauma. In leptin-deficiency, posttraumatic OCN changes are no longer specific and fracture healing is impaired regardless of the preceding trauma.

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