Direct Decompressive Surgery and Radiation Therapy Improved Walking Ability in Metastatic Epidural Spinal Cord Compression

2006 ◽  
Vol 88 (5) ◽  
pp. 1169 ◽  
Keyword(s):  
Spinal Cord ◽  
Radiation Therapy ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Decompressive Surgery ◽  
Walking Ability

Decompressive Surgery for Malignant Spinal Cord Compression (DRAFT)

2018 ◽  
Author(s):  
Esmé Finlay ◽  
Diaa Osman
Keyword(s):  
Spinal Cord ◽  
Radiation Therapy ◽  
Spinal Cord Compression ◽  
Functional Outcomes ◽  
Standard Of Care ◽  
Cord Compression ◽  
Decompressive Surgery ◽  
Functional Quality ◽  
Landmark Study

Metastatic epidural spinal cord compression (MESCC) is a potentially disabling complication associated with advanced cancer. To address whether decompressive surgery followed by radiation therapy is superior to radiation therapy alone, this multi-institutional randomized trial compared outcomes among 101 patients with MESCCC. The study assessed functional outcomes such as ability to ambulate posttreatment, length of ambulation and maintained continence posttreatment, survival time after intervention, and additional functional, quality of life, and medication use outcomes. The practice-changing results of this study indicate that patients who received decompressive surgery and radiation had a longer length of posttreatment ambulation (122 days vs. 13 days, P = 0.03), better overall survival (126 days vs. 100 days, Relative risk 0.60, P = 0.033), lower doses of palliative medications, as well as better performance on several other secondary outcomes. From this landmark study, in appropriately selected patients with MESCC, surgery followed by radiation has become the standard of care.

scholarly journals Who are the Best Candidates for Decompressive Surgery and Spine Stabilization in Patients With Metastatic Spinal Cord Compression?

Spine ◽  
2016 ◽  
Vol 41 (18) ◽  
pp. 1469-1476 ◽  
Author(s):  
Mingxing Lei ◽  
Jianjie Li ◽  
Yaosheng Liu ◽  
Weigang Jiang ◽  
Shubin Liu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Metastatic Spinal Cord Compression ◽  
Decompressive Surgery ◽  
Spine Stabilization

Precision Radiation Therapy for Metastatic Spinal Cord Compression: Final Results of the PRE-MODE Trial

2020 ◽  
Vol 106 (4) ◽  
pp. 780-789 ◽  
Author(s):  
Dirk Rades ◽  
Jon Cacicedo ◽  
Antonio J. Conde-Moreno ◽  
Barbara Segedin ◽  
Jasna But-Hadzic ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Radiation Therapy ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Metastatic Spinal Cord Compression

Long-Term Follow-Up of Patients with Metastatic Epidural Spinal Cord Compression from Solid Tumors Submitted for Surgery Followed by Radiation Therapy

2018 ◽  
Vol 115 ◽  
pp. e681-e687 ◽  
Author(s):  
Federico Pessina ◽  
Pierina Navarria ◽  
Giulio Alberto Carta ◽  
Giuseppe Roberto D'Agostino ◽  
Elena Clerici ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Radiation Therapy ◽  
Solid Tumors ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Long Term Follow Up

scholarly journals Towards answering the optimal palliative fractionation conundrum: single- versus multi-fraction radiation therapy for spinal cord compression

2020 ◽  
Vol 9 (4) ◽  
pp. 1370-1374
Author(s):  
James E. Han ◽  
Robert H. Press ◽  
Shaakir Hasan ◽  
J. Isabelle Choi ◽  
Charles B. Simone II
Keyword(s):  
Spinal Cord ◽  
Radiation Therapy ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
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